Carpal tunnel syndrome and vitamin B6

Guzmán, Francisco Javier Laso; González-Buitrago, José Manuel; Arriba, Felipe de; Mateos, F; Moyano, J. C.; López-Alburquerque, Tomás

doi:10.1007/bf01736533

Cited by 9 publications

(1 citation statement)

References 8 publications

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“…Laso Guzman et al studied clinical and electrodiagnostic changes in 12 CTS patients after treatment with pyridoxine (150 mg/day) for 12 weeks. 31 Although none were previously found to be B 6 deficient based on the EAST assay (a pyridoxine-dependent enzyme assay), all patients showed increased enzyme activity in response to pyridoxine supplementation. After treatment, patients were divided into two groups based on whether or not they clinically improved.…”

Section: Literature In Support Of Pyridoxine Supplementation In Ctsmentioning

confidence: 84%

Pyridoxine Hydrochloride Treatment of Carpal Tunnel Syndrome: A Review

Aufiero¹,

Stitik²,

Foye³

et al. 2004

Nut. Rev.

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It has been hypothesized that idiopathic carpal tunnel syndrome (CTS) is a manifestation of vitamin B6 deficiency. Some claim that B6 supplementation can alleviate symptoms. Others argue that pain relief occurs because of vitamin B6's anti-nociceptive properties or because B6 supplementation addresses an unrecognized peripheral neuropathy. Few studies on CTS and B6 employed electrodiagnostic techniques in diagnosis, and few showed a correlation between symptoms and improved electrodiagnostic parameters with supplementation. Other studies failed to measure or estimate B6 levels. Nevertheless, it appears reasonable to recommend vitamin B6 supplementation to people with CTS. Some patients will improve symptomatically with low risks of toxicity in recommended doses.

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Section: Literature In Support Of Pyridoxine Supplementation In Ctsmentioning

confidence: 84%

Pyridoxine Hydrochloride Treatment of Carpal Tunnel Syndrome: A Review

Aufiero¹,

Stitik²,

Foye³

et al. 2004

Nut. Rev.

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Clinical management of carpal tunnel syndrome: A 12-year review of outcomes

et al. 1999

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Carpal tunnel syndrome (CTS) is a disorder frequently encountered by occupational health care specialists. The health care management of this disorder has involved a diverse set of clinical procedures. The present article is a review of the literature related to CTS with an emphasis on occupational‐related CTS. MEDLINE, Cumulative Index to Nursing and Allied Health Literature, PsycLIT, and NIOSHTIC databases from 1985–1997 were searched for treatment outcome studies related to CTS. Treatments of interest included surgery, physical therapy, drug therapy, chiropractic treatment, biobehavioral interventions, and occupational rehabilitation. A systematic review of the effects of these interventions on symptoms, medical status, function, return to work, psychological well‐being, and patient satisfaction was completed. Compared to other treatments, the majority of studies assessed the effects of surgical interventions. Endoscopic release was associated with higher levels of physical functioning and fewer days to return to work when compared to open release. Limited evidence indicated: 1) steroid injections and oral use of B6 were associated with pain reduction; 2) in comparison to splinting, range of motion exercises appeared to be associated with less pain and fewer days to return to work; 3) cognitive behavior therapy yielded reductions in pain, anxiety, and depression; and, 4) multidisciplinary occupational rehabilitation was associated with a higher percentage of chronic cases returning to work than usual care. Workers' compensation status was associated with increased time to return to work following surgery. Conclusions are preliminary due to the small number of well‐controlled studies, variability in duration of symptoms and disability, and the broad range of reported outcome measures. While there are several opinions regarding effective treatment, there is very little scientific support for the range of options currently used in practice. Despite the emerging evidence of the multivariate nature of CTS, the majority of outcome studies have focused on single interventions directed at individual etiological factors or symptoms and functional limitations secondary to CTS. Am. J. Ind. Med. 35:232–245, 1999. © 1999 Wiley‐Liss, Inc.

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Vitamin B6 status in uremia

Guzmán¹,

González-Buitrago²,

et al. 1990

Klin Wochenschr

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We have studied vitamin B6 status in 26 uremic patients, 18 on maintenance hemodialysis and 8 nonhemodialyzed. The vitamin B6 status was estimated by an assay of erythrocyte aspartate aminotransferase and coenzyme stimulation. Hemodialyzed uremic patients were found to have vitamin B6 deficiency. Patients were treated with 150 mg pyridoxine hydrochloride daily for 4 weeks. Erythrocyte aspartate aminotransferase increased significantly in both groups of uremic patients, the increase being greater in hemodialyzed patients. In vitro pyridoxal phosphate stimulation produces an erythrocyte aspartate aminotransferase activity greater than that obtained before pyridoxine hydrochloride administration. After cessation of pyridoxine hydrochloride treatment, erythrocyte aspartate aminotransferase decreases in hemodialyzed patients, while it remains elevated in nonhemodialyzed patients. The data obtained appear to indicate that vitamin B6 administration to patients with chronic renal insufficiency must be appraised not only for correcting the deficit but also for increasing the intracellular pyridoxal phosphate concentration, which could modify the possible functional impairment at the level of apoenzymes that use pyridoxal phosphate.

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Carpal tunnel syndrome and vitamin B6

Cited by 9 publications

References 8 publications

Pyridoxine Hydrochloride Treatment of Carpal Tunnel Syndrome: A Review

Pyridoxine Hydrochloride Treatment of Carpal Tunnel Syndrome: A Review

Clinical management of carpal tunnel syndrome: A 12-year review of outcomes

Vitamin B6 status in uremia

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