Entrapment neuropathies are common and are frequently encountered by physicians in clinical practice. Median nerve entrapment, being one of the most common neuropathies in the upper extremity, must be studied in detail if the extent of injury it can cause is to be understood fully. Various anatomical variations are discovered frequently and reviewing these will advance medical practice in the search for suitable treatments. A broad understanding of the symptoms of median nerve entrapment, motor as well as sensory, is essential, along with its effects on surrounding structures.