Carpal tunnel syndrome and oral contraceptive drugs: risk or protective factor?

Albani, Giovanni; Priano, Lorenzo; Campanelli, L.; Pignatti, Riccardo; Liuzzi, Antonio; Galloti, Pietro; Mauro, Alessandro

doi:10.1111/j.1085-9489.2003.03026.x

Cited by 7 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This association was consistent with previous evidence, as any factor influencing hormonal status, either exogenous (including oral contraceptives and hormone replacement therapy) or endogenous (i.e., menstrual problems such as amenorrhea, heavy periods, dysmenorrhea, but also menopause) was previously identified as a risk factor for CTS [14,39]. A previous or coexisting diagnosis of musculoskeletal disorders has been frequently reported in CTS patients [31,40], but the appearance of CTS after the upper limb trauma and/or upper limb surgery has been rarely evaluated and usually interpreted as a rare issue [15,41,42].…”

Section: Discussionsupporting

confidence: 92%

Personal risk factors for carpal tunnel syndrome in female visual display unit workers

Riccò¹,

Cattani²,

Signorelli³

2016

Int J Occup Med Environ Health

View full text Add to dashboard Cite

Objectives: Carpal tunnel syndrome (CTS) is the most common nerve entrapment syndrome, which since the beginning of the seventies has been linked to the keyboard and visual display unit (VDU). The objective of this study was to investigate the prevalence and personal factors associated with CTS in female VDU workers in Italy. Material and Methods: Participants in this study were female adult subjects, working ≥ 20 h/week (N = 631, mean age 38.14±7.81 years, mean working age 12.9±7.24 years). Signs and symptoms were collected during compulsory occupational medical surveillance. The binary logistic regression was used to estimate adjusted odds ratios for the factors of interest. Results: Diagnosis of CTS was reported in 48 cases (7.6%, 11 of them or 1.7% after a surgical correction) for the incidence of 5.94/1000 person-years. In general, signs and symptoms of CTS were associated with the following demographic factors: previous trauma of upper limb (adjusted odds ratio (OR a ) = 8.093, 95% confidence interval (CI): 2.347-27.904), history (> 5 years) of oral contraceptives therapy/hormone replacement therapy (OR a = 3.77, 95% CI: 1.701-8.354) and cervical spine signs/symptoms (OR a = 4.565, 95% CI: 2.281-9.136). Conclusions: The prevalence of CTS was similar to the estimates for the general population of Italy. Among personal risk factors, hormone therapy, previous trauma of the upper limb and signs/symptoms of the cervical spine appeared to be associated with a higher risk of CTS syndrome. Eventually, the results reinforce interpretation of CTS in VDU workers as a work-related musculoskeletal disorder rather than a classical occupational disease. Int J Occup Med Environ Health 2016;29(6):927-936

show abstract

Section: Discussionsupporting

confidence: 92%

Personal risk factors for carpal tunnel syndrome in female visual display unit workers

Riccò¹,

Cattani²,

Signorelli³

2016

Int J Occup Med Environ Health

View full text Add to dashboard Cite

show abstract

“…Among female participants, history of the OCT/HRT and previous pregnancies were more frequently reported by the CTS. These associations are consistent with previous evidences, as the hormonal status has been identified as a significant risk factor for the CTS [59][60][61]. The use of β-blockers has been more controversially reported among the risk factors for the CTS since the late 1980's, and the underlying mechanism may similarly result from the drugrelated fluid retention and oedema [51,62,63].…”

Section: Discussionsupporting

confidence: 90%

Personal and occupational risk factors for carpal tunnel syndrome in meat processing industry workers in Northern Italy

Riccò

Signorelli

2017

Med Pr

View full text Add to dashboard Cite

Background: Carpal tunnel syndrome (CTS) is a musculoskeletal condition that often impairs the fitness to work. Our aim is to retrospectively evaluate the association between physical exposures in meat processing industry in Northern Italy and the CTS, taking into account non-occupational factors. Material and Methods: A cross-sectional study was performed to include 434 workers (236 males, 198 females, 37.0±10.6 years old, working age: 12.6±10.8 years) from meat processing industries. Signs and symptoms were collected at the compulsory occupational medical surveillance. Occupational risk factors were assessed through a questionnaire and direct assessment by investigators. Adjusted odds ratios (ORadj) for factors of interest were estimated through binary logistic regression. Results: Diagnosis of the CTS was reported for 61 out of 434 subjects (14.1%) for an incidence of 11.3/1000 person-years. In general, signs and symptoms for the CTS were associated with the following demographic factors: smoking history (OR = 1.909, 95% confidence interval (CI): 1.107-3.293), previous traumas of the upper limb (OR = 3.533, 95% CI: 1.743-7.165), hypothyroidism status (OR = 7.897, 95% CI: 2.917-21.38) and, in the case of female participants only, previous pregnancies (OR = 2.807, 95% CI: 1.200-6.566) as well as a personal history of oral contraceptive therapy and/or steroidal replacement therapy (OR = 11.57, 95% CI: 4.689-28.56). The carpal tunnel syndrome cases were associated with the following occupational factors (> 4 h/day): forceful hand exertion (ORadj = 3.548, 95% CI: 1.379-9.131), repeated trauma of the hand (ORadj = 3.602, 95% CI: 1.248-10.395), repeated movements of the wrist (ORadj = 2.561, 95% CI: 1.100-5.960). Conclusions: Increasing levels of hand activity and force were associated with the increased CTS prevalence among participants. Recommendations have to be provided in order to reduce occupational exposure to these risk factors and improve medical surveillance. Med Pr 2017;68(2) :199-209

show abstract

“…The estimated prevalence of CTS was reported to be about 6.8% in women and 0.6% in men (3, 4). Obesity, smoking, pregnancy, diabetes mellitus, hypothyroidism, hyperthyroidism, hormonal replacement therapy and corticosteroid use were reported in association with CTS (5–12). The association was also reported with rheumatoid arthritis, osteoarthritis and wrist fractures (5, 7, 13).…”

Section: Introductionmentioning

confidence: 99%

Carpal tunnel syndrome and metabolic syndrome

Balcı

Utku

2007

Acta Neurol Scand

View full text Add to dashboard Cite

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Many factors such as diabetes mellitus, hypothyroidism, hormonal replacement therapy, corticosteroid use, rheumatoid arthritis and wrist fractures may cause CTS. Metabolic syndrome includes abdominal obesity, dyslipidemia, hyperglycemia, and hypertension that may cause CTS. In this study, we aimed to evaluate the relation between CTS and metabolic syndrome. We studied 107 (96 female and 11 male) right-handed patients who had a clinical and electrophysiologically confirmed diagnosis of CTS. We then divided the patients into two groups (patients with and without metabolic syndrome) according to the criteria of ATP III definition. Eighty (75%) of the patients with CTS had metabolic syndrome. Among the 80 patients with metabolic syndrome, CTS was found in 150 hands (43 mild, 58 moderate and 49 severe cases). Among the 27 patients without metabolic syndrome, CTS was found in 43 hands (27 mild, 14 moderate and 2 severe cases). The electrophysiological parameters (median nerve distal motor latency, median nerve motor amplitude, median nerve motor conduction velocity, median nerve sensory onset latency, median nerve sensory amplitude and median nerve sensory conduction velocity) were worse in patients with metabolic syndrome (P < 0.05). In conclusion, metabolic syndrome was found to be three times more common in patients with CTS and CTS was more severe in patients with metabolic syndrome when compared with those without metabolic syndrome.

show abstract

Carpal tunnel syndrome and oral contraceptive drugs: risk or protective factor?

Cited by 7 publications

References 5 publications

Personal risk factors for carpal tunnel syndrome in female visual display unit workers

Personal risk factors for carpal tunnel syndrome in female visual display unit workers

Personal and occupational risk factors for carpal tunnel syndrome in meat processing industry workers in Northern Italy

Carpal tunnel syndrome and metabolic syndrome

Contact Info

Product

Resources

About