Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF‐I concentrations

Cohn, Lester; Feller, Axel G.; Draper, Michael W.; Rudman, Inge W.; Rudman, Daniel

doi:10.1111/j.1365-2265.1993.tb02388.x

Cited by 132 publications

(50 citation statements)

References 32 publications

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“…ND possibly caused symptomatic fluid retention (oedema and carpal tunnel syndrome, which can be triggered by fluid retention [37]) in 2 subjects, despite both subjects having reasonable dialysis adequacy. The reason for this is unclear, but may be related to these patients’ degree of residual renal function (which was not assessed in the present study).…”

Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate as Anabolic Therapy in Chronic Kidney Disease: A Randomized Phase II Dose-Finding Study

et al. 2007

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Background/Aims: In patients with chronic kidney disease (CKD) receiving adequate erythropoietin therapy, the ideal dose of nandrolone decanoate (ND) to enhance muscle mass is not known. Methods: In this phase II dose-finding study, 54 patients with CKD stage 5 were randomized to either low, medium or high doses of ND (50, 100 or 200 mg/week for 24 weeks, respectively, in males; doses halved in females), while 7 patients acted as non-randomized controls. The primary outcome measure was appendicular lean mass (ALM) by dual-energy X-ray absorptiometry. Fluid overload (hydration of the fat-free mass) and indicators of physical functioning were secondary measures. Harms were also recorded. Data were analysed using Quade’s (1967) non-parametric analysis of covariance. Results: ND increased ALM in a dose-responsive manner (change scores = 0.3 ± 0.3 vs. 0.8 ± 0.3 vs. 1.5 ± 0.5 vs. 2.1 ± 0.4 kg, control vs. low vs. medium vs. high dose groups, respectively, p < 0.001) with no increases in fluid overload but no consistent effect on physical functioning. The highest dose of ND (100 mg/week) was intolerable in females because of virilizing effects. Conclusion: If goals of future studies are to improve body composition, dosing of ND up to 200 mg/week in males and 50 mg/week in females should be investigated. However, to realize improvements in physical functioning, future phase III trials of ND may require additional interventions such as exercise training.

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Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate as Anabolic Therapy in Chronic Kidney Disease: A Randomized Phase II Dose-Finding Study

et al. 2007

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“…Cessation of IGF-I therapy has resulted in regression in all reported cases (161). Gynecomastia has been reported as a rare occurrence in elderly men (162).…”

Section: Reported Adverse Effects Of Gh Replacementmentioning

confidence: 99%

Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review

Carroll¹,

Christ²,

Bengtsson³

et al. 1998

The Journal of Clinical Endocrinology & Metabolism

706

455

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“…In a group of elderly men that underwent GH replacement therapy for six months, Cohn, Rudman et al reported a side-effect withdrawal rate of 43% compared to 9% in the placebo group. The most common symptoms were carpal tunnel syndrome, gynecomastia, and hyperglycemia [51]. Yarasheski et al reported a similarly high incidence of carpal tunnel syndrome, edema, and arthralgia [52].…”

Section: Possible Adverse Effects Of Gh Use In Patients Without Aghdmentioning

confidence: 94%

Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

Rucker¹,

Sá²,

Arbex³

2017

Health

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Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been suggested as "anti-aging" therapies, or for improving quality of life with aging. In this study, we focus on the actions of GH in the main organs and organ systems of the human body, like skeletal muscle, bones and brain, particularly in regard to data and research on the use of GH replacement therapy in adults without growth hormone deficiency, especially elderly patients. Several different studies have been carried out to show what the effects and side effects of GH replacement in healthy people and what would be the impact in quality of life and life span. In this review, we demonstrate what answers we have so far about the effects of GH replacement in many organs and systems in healthy people.

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Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF‐I concentrations

Cited by 132 publications

References 32 publications

Nandrolone Decanoate as Anabolic Therapy in Chronic Kidney Disease: A Randomized Phase II Dose-Finding Study

Nandrolone Decanoate as Anabolic Therapy in Chronic Kidney Disease: A Randomized Phase II Dose-Finding Study

Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review

Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

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