Carotid stiffness change over the cardiac cycle by ultrafast ultrasound imaging in healthy volunteers and vascular Ehlers–Danlos syndrome

Mirault, Tristan; Pernot, Mathieu; Frank, Michael; Couade, Mathieu; Niarra, Ralph; Azizi, Michel; Emmerich, Joseph; Jeunemaı̂tre, Xavier; Fink, Mathias; Tanter, Mickaël; Messas, Emmanuel

doi:10.1097/hjh.0000000000000617

Cited by 55 publications

(66 citation statements)

References 39 publications

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“…Regarding coronary stiffness, if it increases, as it is the case after elongation, PWV will increase. This has been reported for the carotid artery, with significantly lower PWV in early systole compared to end systole (Mirault et al, 2015), and observed herein; there was a trend toward higher CoPWV measured in the elongated artery (decompression: DIC and TM) than when this was measured in a relaxed artery (compression phase: FW). Furthermore, these methods were poorly correlated with the compression FW method.…”

Section: Discussionsupporting

confidence: 87%

Comprehensive assessment of coronary pulse wave velocity in anesthetized pigs

et al. 2020

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Background: Coronary stiffness represents a new paradigm for interventional cardiology and can be assessed by coronary pulse wave velocity (CoPWV). Assessing CoPWV is complex because of the coexistence of backward and forward waves. Objectives: Evaluate the feasibility, repeatability, and capacity of methods assessing CoPWV to detect predictable velocity changes. Methods: CoPWV was measured from distal and proximal pressure guidewires in the left anterior descending artery of 10 pigs under general anesthesia. Four methods were studied: the tangent intersection method applied to the forward (FW) and backward (BK) waves, as well as the dicrotic notch (DIC) and template matching (TM) methods. All were evaluated at baseline, during various arterial pressure and heart rate conditions, during simulated flow limitation (balloon inflation), and after increasing coronary stiffness (stent insertion). Results: All the methods were significantly different between them (p ≤ .05) showing a systematic trend toward higher CoPWV when compared to the FW method (.05 < p<.10). Results were found to be significantly correlated only between the BK and FW methods and between the DIC and TM methods (p ≤ .05). CoPWV increased with arterial pressure increase, this increase being significant for the DIC and TM methods and partly for the FW method (p ≤ .05). Conversely, heart rate had no systematic impact on CoPWV. The lowest variability was found for the DIC and TM methods (p ≤ .05). Only the BK and TM methods remained applicable during flow limitation; stent increased CoPWV when measured by the BK method only (p ≤ .05). Conclusion: Although CoPWV can be measured by various methods, the BK and TM methods seem the most appropriate for clinical studies. K E Y W O R D Scoronary physiology, coronary stiffness, pulse wave velocity

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Section: Discussionsupporting

confidence: 87%

Comprehensive assessment of coronary pulse wave velocity in anesthetized pigs

et al. 2020

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“…In order to evaluate the accuracy and reliability of the proposed empirical model, reference measurements were obtained by implementing the BH equation given in (4). This approach is recognized as the reference-standard for local PWV measurement [10].…”

Section: Assessment Of Reference Measurementmentioning

confidence: 99%

“…Typically, local PWV from target arterial sites (artery under clinical investigation) is evaluated for a single and the most convenient fiduciary point from each cardiac cycle and averaged over the measurement period. Although such single-value estimates are associated with various pathophysiological conditions [1], instantaneous variation and the degree of change in local PWV within a cardiac cycle have recently been recognized as key measures for advanced cardiovascular screening and diagnosis [3][4][5]. Physiologically, the instantaneous variation in local PWV occurs due to the dependency of vessel elasticity on the arterial transmural pressure (blood pressure (BP)) [6].…”

Section: Introductionmentioning

confidence: 99%

Determination of Incremental Local Pulse Wave Velocity Using Arterial Diameter Waveform: Mathematical Modeling and Practical Implementation

Nabeel¹,

Raj²,

Joseph³

et al. 2019

2019 Computing in Cardiology Conference (CinC)

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Background and Aim: Given the knowledge of the noninvasive assessment of local pulse wave velocity (PWV) for cardiovascular risk stratification, it is apparent that it is necessary to develop a practically feasible solution to measure and trace instantaneous variations in local PWV (incremental local PWV) from the target arteries.Methods: From the arterial blood pulse propagation characteristics, wave nature of the transmural pressure, and the distending vessel wall geometry, a mathematical model was developed to evaluate incremental local PWV using arterial diameter waveform. Its practical feasibility and the measurement accuracy were demonstrated invivo using a custom image-free ultrasound device, with the Bramwell-Hill method as the reference.Results: The proposed technique and developed device reliably captured incremental local PWV from the carotid artery. The locus of instantaneous variations in carotid local PWV obtained using the developed model traced the reference values, with a root-mean-square-error lesser than 0.05 m/s. Study results further established the practical feasibility and accuracy of this novel approach.Conclusion: The theoretical basis and measurement method of this work is a solution for non-invasive, realtime assessment of incremental local PWV and its locus.

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“…Indeed, plane wave imaging allows a high-framerate of more than 1 000 images per second (according to depth of interest) against 150 images per second at most for conventional imaging [2]. This increased framerate is useful to image fast phenomena of tissues [3], [4]. Plane wave imaging is used for artery elasticity assessment as well as flow estimation [5], [6].…”

Section: Introductionmentioning

confidence: 99%