hooge, J., Larsson, M. (2015) Ultrasound speckle tracking strain estimation of in vivo carotid artery plaque with in vitro sonomicrometry validation. in CCA gel-phantoms with a plaque mimicking inclusion using an in-house ST algorithm and 3 sonomicrometry. Moreover, plaque strain by ST from 7 patients (77 ± 6 years) with carotid 4 atherosclerosis was compared with a quantitative visual assessment by two experienced physicians. 5
Ultrasound in Medicine andIn vitro, good correlation existed between ST and sonomicrometry peak strain both radially (r = 6 0.96, p < 0.001) and longitudinally (r = 0.75, p < 0.01). In vivo, a greater pulse-pressure adjusted 7 radial and longitudinal strain was found in echolucent plaques compared to echogenic plaques. This 8 study shows the feasibility of ultrasound ST strain estimation in plaques and indicates the 9 possibility to characterize plaques using ST strain in vivo. 10 11