Carotid MRI Detection of Intraplaque Hemorrhage at 3T and 1.5T

McNally, J. Scott; Yoon, Hyo‐Chun; Kim, Seong Eun; McLaughlin, Michael; Parker, Dennis L.; Treiman, Gerald S.

doi:10.1111/jon.12146

Cited by 31 publications

(47 citation statements)

References 37 publications

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“…This is likely because the effect of magnet strength on gross MPRAGE positive or negative status is small, on the order of 10% in our recent study. 37 In addition, 3-T magnets are used far less often than 1.5-T magnets in the evaluation of acute stroke at our institution. The results of this study further suggest that IPH detection can and should be used as part of stroke source workup at both magnet strengths.…”

Section: Discussionmentioning

confidence: 99%

Intraluminal Thrombus, Intraplaque Hemorrhage, Plaque Thickness, and Current Smoking Optimally Predict Carotid Stroke

McNally

McLaughlin

Hinckley

et al. 2015

Stroke

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Background and Purpose-Intraplaque hemorrhage (IPH) is associated with acute and future stroke. IPH is also associated with lumen markers of stroke risk including stenosis, plaque thickness, and ulceration. Whether IPH adds further predictive value to these other variables is unknown. The purpose of this study was to determine whether IPH improves carotid-source stroke prediction. Methods-In this retrospective cross-sectional study, patients undergoing stroke workup were imaged with MRI and IPH detection. Seven hundred twenty-six carotid-brain image pairs were analyzed after excluding vessels with noncarotid plaque stroke sources (420) and occlusions (7)

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Section: Discussionmentioning

confidence: 99%

Intraluminal Thrombus, Intraplaque Hemorrhage, Plaque Thickness, and Current Smoking Optimally Predict Carotid Stroke

McNally

McLaughlin

Hinckley

et al. 2015

Stroke

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“…6 21 To produce 3D images, we used a secondary phaseencoding gradient in the section-select direction, and measurements for all section-selection phase encodings were performed with rapid acquisition in each segment. Carotid IPH was determined by MPRAGE-positive plaque with at least 1 voxel demonstrating at least 2-fold higher signal intensity relative to adjacent sternocleidomastoid muscle as previously described.…”

Section: Iph Determination By Mpragementioning

confidence: 99%

“…[2][3][4][5] Carotid IPH can be detected with heavily T1-weighted sequences, including the MPRAGE sequence, which can discriminate between IPH and lipid/necrotic core. 6 MPRAGE is superior in detecting IPH compared with conventional MR imaging sequences, with higher sensitivity, specificity, and interrater reliability compared with 3D TOF or FSE T1WI sequences. 7 Lumen markers have been linked to IPH, including stenosis, plaque thickness, and ulceration.…”

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confidence: 93%

Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA

Eisenmenger

Aldred

Kim

et al. 2016

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:Carotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our goal was to determine whether adventitial calcification and soft plaque (a rim sign) help predict carotid intraplaque hemorrhage.

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“…34 The MPRAGE sequence selectively detects IPH as opposed to the LRNC, with the added benefit of having high inter-and intrarater reliability. 29 Because these 3D heavily T1-weighted sequences can be limited by motion and flow-related artifact, cine-MPRAGE and radially acquired stack of stars (SOS) MPRAGE were developed to allow easy separation of IPH from artifact.…”

Section: 36mentioning

confidence: 99%

Advanced imaging in acute ischemic stroke

Kilburg¹,

McNally

Havenon

et al. 2017

FOC

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The evaluation and management of acute ischemic stroke has primarily relied on the use of conventional CT and MRI techniques as well as lumen imaging sequences such as CT angiography (CTA) and MR angiography (MRA). Several newer or less-established imaging modalities, including vessel wall MRI, transcranial Doppler ultrasonography, and 4D CTA and MRA, are being developed to complement conventional CT and MRI techniques. Vessel wall MRI provides high-resolution analysis of both extracranial and intracranial vasculature to help identify previously occult lesions or characteristics of lesions that may portend a worse natural history. Transcranial Doppler ultrasonography can be used in the acute setting as a minimally invasive way of identifying large vessel occlusions or monitoring the response to stroke treatment. It can also be used to assist in the workup for cryptogenic stroke or to diagnose a patent foramen ovale. Four-dimensional CTA and MRA provide a less invasive alternative to digital subtraction angiography to determine the extent of the clot burden and the degree of collateral blood flow in large vessel occlusions. Along with technological advances, these new imaging modalities are improving the diagnosis, workup, and management of acute ischemic stroke— roles that will continue to expand in the future.

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Carotid MRI Detection of Intraplaque Hemorrhage at 3T and 1.5T

Abstract: BACKGROUND AND PURPOSE-Carotid intraplaque hemorrhage leads to plaque progression and ischemic events.

Cited by 31 publications

References 37 publications

Intraluminal Thrombus, Intraplaque Hemorrhage, Plaque Thickness, and Current Smoking Optimally Predict Carotid Stroke

Intraluminal Thrombus, Intraplaque Hemorrhage, Plaque Thickness, and Current Smoking Optimally Predict Carotid Stroke

Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA

Advanced imaging in acute ischemic stroke

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