Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes

Dayem, Soha M. Abd El; Bohy, Abo El Magd El; Battah, Ahmed A.

doi:10.1515/jpem-2014-0355

Cited by 11 publications

(11 citation statements)

References 45 publications

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“…Abnormalities in myocardial function were recently reported, besides early vascular endothelial dysfunction induced by DM1. It was also reported that early atherosclerotic changes in the adolescents were associated with diabetic nephropathy, supporting that diabetic microangiopathy and macroangiopathy are related to each other in type 1 diabetic patients [20]. …”

Section: Discussionmentioning

confidence: 86%

Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus

Fusaro

Zanini

Silva

2016

Diabetol Metab Syndr

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BackgroundIncreased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic diseases, including type 1 diabetes mellitus (DM1).ObjectivesEvaluate CIMT and its association with cardiovascular risk factors in Brazilian adolescents with DM1.MethodsCross-sectional study of 118 adolescents, 57 with DM1 and no chronic complications related to the disease, and 61 healthy individuals. Clinical, biochemical, and high-resolution B-mode ultrasonographic evaluations according to the Consensus Statement of the American Society of Echocardiography CIMT Task Force were performed.ResultsAdolescents with diabetes (66.6% female) were 14.5 ± 2.9 years old and had 9.0 ± 4.0 years of disease duration. The healthy adolescents (62.3% female) were 14.3 ± 2.6 years old. All the adolescents had blood pressure within their reference ranges. In 66% of DM1 adolescents the systolic blood pressure was >50th percentile. Increased CIMT was observed in adolescents with diabetes compared with those in the control group: 0.53 vs 0.51 mm (p < 0.004) on the right side, and 0.55 vs 0.51 mm (p < 0.001) on the left side. CIMT presented independent and positive associations with diabetes duration, total cholesterol level, low-density lipoprotein cholesterol level, and systolic blood pressure percentile in DM1 adolescents.ConclusionsIncreased CIMT was observed in young Brazilian adolescents with DM1, and was associated with cardiovascular risk factors. CIMT assessment may be useful for the early identification and monitoring of cardiovascular risk in this age group.

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Section: Discussionmentioning

confidence: 86%

Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus

Fusaro

Zanini

Silva

2016

Diabetol Metab Syndr

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“…Use of IMT testing can also detect marked thickening of the arterial wall, possibly indicating plaques or atheromas that are associated with accelerated atherosclerotic disease and increased risk for coronary artery disease, myocardial infarction, and stroke [5]. Many studies have been detected increased IMT in young diabetic children [6-8]. In young and middle-aged adults, increased IMT was also associated with cardiovascular risk factors [8-11].…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have been detected increased IMT in young diabetic children [6-8]. In young and middle-aged adults, increased IMT was also associated with cardiovascular risk factors [8-11]. …”

Section: Introductionmentioning

confidence: 99%

Assessment of Increase in Aortic and Carotid Intimal Medial Thickness in Type 1 Diabetic Patients

Dayem

Battah

Bohy

2016

Open Access Maced J Med Sci

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AIM:To assess aortic and carotid intima-media thickness (aIMT and cIMT) in diabetic patients.PATIENTS AND METHODS:The study included 75 type 1 diabetic patients and 30 age and sex matched healthy volunteer. A blood sample was taken for analysis of HbA1 and lipid profile and the urine sample was taken for analysis of albumin/creatinine ratio. aIMT and cIMT via ultrasound were also done.RESULTS:cIMT & aIMT were significantly higher in diabetics. aIMT was found to be significantly higher than cIMT in diabetic patients (0.72 ± 0.11 vs. 0.52 ± 0.06, P = 0.0001). Ten of our patients (14%) with normal cIMT revealed significantly increased aIMT. aIMT had a significant positive correlation with age of patients, waist/hip ratio & cIMT.CONCLUSION:Diabetic patients had increased aIMT and cIMT with a relatively greater increase in the aIMT than in the cIMT. Because atherosclerosis begins first in the intima of the aorta, these data suggest that the aIMT might provide the best currently available noninvasive marker of preclinical atherosclerosis in children. We recommend frequent follow up of diabetic patients for early detection of diabetic complication.

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“…Järvisalo et al, [17] revealed that young type 1 diabetic patients had an increased incidence of subclinical atherosclerosis. McGill et al, [12] found that intima of the abdominal aorta is affected before intima of the carotid artery and aIMT is an early diagnosis of preclinical atherosclerosis in children [18].…”

Section: Discussionmentioning

confidence: 99%

Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients

Dayem

Battah

Bohy

et al. 2019

Open Access Maced J Med Sci

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AIM: To evaluate copeptin as an early marker of atherosclerosis in adolescent type 1 diabetics. METHODS: Sixty-two type 1 diabetic patients and 50 healthy volunteers were enrolled in the study. Serum copeptin, glycosylated haemoglobin (HbA1c), lipid profile, oxidised low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio, carotid intimal medial thickness (cIMT), aortic intimal medial thickness (aIMT) and resistivity index were assessed for all participant in the study. RESULTS: HbA1, albumin/creatinine ratio, lipid profile, OxlDL, copeptin, cIMT and aIMT were significantly higher in diabetic patients. Copeptin was higher in patients with positive cIMT and aIMT. Copeptin correlated with cIMT and aIMT. Stepwise multiple regression analysis found that copeptin correlated with aIMT. ROC curve showed that copeptin had 100 % specificity with aIMT and cIMT and 95.2 and 60,7 sensitivity with aIMT and cIMT respectively. CONCLUSION: Copeptin can be used as a marker for early detection of atherosclerosis of type 1 diabetic patients.

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Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes

Abstract: We conclude that alteration in myocardial function and vascular endothelial dysfunction induced by diabetes mellitus may begin early with the association of early atherosclerotic changes.

Cited by 11 publications

References 45 publications

Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus

Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus

Assessment of Increase in Aortic and Carotid Intimal Medial Thickness in Type 1 Diabetic Patients

Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients

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