Carotid Intima-Media Thickness in Patients With a History of Kawasaki Disease

Dietz, Sanne M.; Tacke, Carline E.; Gort, Johan; Kuipers, Irene M.; Groot, Eric de; Wiegman, Albert; Hutten, Barbara A.; Kuijpers, Taco W.

doi:10.1253/circj.cj-15-0555

Cited by 19 publications

(26 citation statements)

References 28 publications

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“…This study is the first longitudinal cIMT study in KD, demonstrating a gradual increase in cIMT in KD patients with giant aneurysms and showing that patients without history of CAAs demonstrated normalization of cIMT with time, despite an initial increase in cIMT compared with controls. These findings are similar to those of the cross‐sectional study by Dietz et al, who observed increased cIMT in all patients with CAAs, whereas in patients with no CAAs, increased cIMT was apparent only at a young age, suggesting similar regression of cIMT with time . In a similar cross‐sectional study by Selamet Tierney et al, there was no significant difference in cIMT in KD patients with no CAAs and control patients .…”

supporting

confidence: 89%

Patterns of Carotid Intima–Media Thickness Progression in Kawasaki Patients: A Crystal Ball for Long‐Term Vascular Health?

Haley

Tierney

2016

JAHA

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supporting

confidence: 89%

Patterns of Carotid Intima–Media Thickness Progression in Kawasaki Patients: A Crystal Ball for Long‐Term Vascular Health?

Haley

Tierney

2016

JAHA

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“…38,39 KD is an acute systemic inflammation of blood vessels of unknown etiology, which occurs in young children. 40 Former KD patients might have an increased predisposition to atherosclerosis and endothelial damage. 40 Although still controversial 41 and possibly depending on the magnitude of the coronary artery aneurysm caused by KD, 42 some studies report increased CIMT in acute and healed KD.…”

Section: Discussionmentioning

confidence: 99%

“…40 Former KD patients might have an increased predisposition to atherosclerosis and endothelial damage. 40 Although still controversial 41 and possibly depending on the magnitude of the coronary artery aneurysm caused by KD, 42 some studies report increased CIMT in acute and healed KD. [42][43][44] The linkage analysis for CIMT identified a region on chromosome 4 with the LOD-1 support interval spanning 14 Mb encompassing 74 genes.…”

Section: Discussionmentioning

confidence: 99%

Linkage and Association Analysis Identifies TRAF1 Influencing Common Carotid Intima–Media Thickness

Heßler

Geisel

Coassin

et al. 2016

Stroke

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A therosclerosis is one of the most common causes of death and disability worldwide. 1 Because it is more common in the elderly population, its public health impact will continuously increase with growing life expectancy. Several genetic and environmental risk factors have been identified to be associated with atherosclerosis and 2 of its most deleterious clinical manifestations myocardial infarction and stroke.2 Common carotid intima-media thickness (CIMT) is a widely used marker for subclinical atherosclerosis.3 CIMT is influenced by genetic factors and by classical risk factors, such as smoking, blood pressure, diabetes mellitus, or plasma lipid levels. 4 The consideration of this endophenotype in genetic studies has several advantages: CIMT can be quantified, is easily accessible with a noninvasive method, and is an early indicator of atherosclerosis and a predictor for myocardial infarction and stroke. 5-7Few genome-wide linkage studies have been conducted to map the genetic factors influencing CIMT and did report inconsistent results. [8][9][10][11] One explanation might be that the measurement protocols for CIMT varied between studies as did the genetic background of the study populations and the genotyping technologies. Despite these differences, the largest and most recent genome-wide association meta-analysis, includingBackground and Purpose-Carotid intima-media thickness is a marker for subclinical atherosclerosis that predicts subsequent clinical cardiovascular events. The aim of this study was to identify chromosomal loci with linkage or association to common carotid intima-media thickness. Methods-Nuclear families were recruited using the single parental proband sib-pair design. Genotype data were available for 546 individuals from 132 nuclear families of the Bonn IMT Family Study using the Affymetrix GeneChip Human Mapping 250K Sty chip. Multipoint logarithm of the odds (LOD) scores were determined with the quantitative trait locus statistic implemented in multipoint engine for rapid likelihood. Linkage analysis and family-based association tests were conducted. Data from 2471 German participants from the HNR (Heinz Nixdorf Recall) Study were used for subsequent replication. Results-Two new genomic regions with suggestive linkage (LOD>2) were identified on chromosome 4 (LOD=2.26) and on chromosome 17 (LOD=2.01). Previously reported linkage findings were replicated on chromosomes 13 and 14. Fifteen single nucleotide polymorhisms, located on chromosomes 4, 6, and 9, revealed P<10 -4 in the family-based association analyses. One of these signals was replicated in HNR (rs2416804, 1-sided P=1.60×10

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“…Furthermore, the included studies had a cross‐sectional design or were cohort studies with short follow‐up (<6 months) and were not able to show the course of the cIMT change over time. In our own cross‐sectional study, we observed that children with KD had significantly increased cIMT following early disease compared with siblings . In a large number of patients, ≥2 cIMT measurements were obtained.…”

Section: Introductionmentioning

confidence: 95%

Extracardial Vasculopathy After Kawasaki Disease: A Long‐Term Follow‐up Study

Dietz

Tacke

Groot

et al. 2016

JAHA

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BackgroundKawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysm (CAA) as a major complication. Controversy exists about cardiovascular risk later in life. The aim of our study was to evaluate whether KD patients are at increased risk, as assessed by carotid intima‐media thickness (cIMT).Methods and ResultsWe measured cIMT over 15 years by B‐mode ultrasonography in KD patients during follow‐up and in unaffected controls (mostly siblings). A multilevel, repeated‐measures, linear mixed‐effects model was used to evaluate the association between KD and cIMT. A total of 319 patients with 528 measurements were compared with 150 controls. In KD patients, the mean cIMT was increased compared with controls (0.375 mm [95% CI 0.372–0.378 mm] versus 0.363 mm [95% CI 0.358–0.368 mm]; P<0.001). Furthermore, mean cIMT of CAA‐negative patients was 0.373 mm (P<0.01 compared with controls), of patients with small–medium CAA was 0.374 mm (P<0.05 compared with controls), and of patients with giant CAA was 0.381 mm (P<0.01 compared with controls). Compared with controls, CAA‐negative participants started with an increased cIMT (+0.0193±0.0053 mm, P<0.001) but showed slower progression (−0.0014±0.0006 mm/year, P=0.012). Patients with giant CAA showed a trend toward increased cIMT progression (0.0013±0.0007 mm/year, P=0.058).ConclusionsWe observed a positive correlation between cIMT and KD severity of coronary arteritis at the acute stage. Although initially increased, the cIMT in CAA‐negative patients normalized at a later age. In contrast, patients with a history of KD complicated by giant CAA showed a trend toward persistently increased cIMT. These patients may need cardiovascular counseling and follow‐up beyond the heart.

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Carotid Intima-Media Thickness in Patients With a History of Kawasaki Disease

Cited by 19 publications

References 28 publications

Patterns of Carotid Intima–Media Thickness Progression in Kawasaki Patients: A Crystal Ball for Long‐Term Vascular Health?

Patterns of Carotid Intima–Media Thickness Progression in Kawasaki Patients: A Crystal Ball for Long‐Term Vascular Health?

Linkage and Association Analysis Identifies TRAF1 Influencing Common Carotid Intima–Media Thickness

Extracardial Vasculopathy After Kawasaki Disease: A Long‐Term Follow‐up Study

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