Carotid intima-media thickness for cardiovascular risk assessment: Systematic review and meta-analysis

Oord, Stijn C.H. van den; Sijbrands, Eric J.G.; Kate, Gerrit L. ten; Klaveren, David van; Domburg, Ron T. van; Steen, Antonius F.W. van der; Schinkel, Arend F. L.

doi:10.1016/j.atherosclerosis.2013.01.025

Cited by 257 publications

(213 citation statements)

References 61 publications

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“…IMT is considered a surrogate marker for atherosclerosis and a strong predictor of future cardiovascular events [29][30][31]. However, many methods are used to measure IMT.…”

Section: Discussionmentioning

confidence: 99%

Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism

et al. 2016

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PRIMARY ALDOSTERONISM (PA) is characterized by excessive secretion of the mineralocorticoid hormone aldosterone and is frequently caused by an aldosterone-secreting adrenocortical adenoma or adrenal hyperplasia [1,2]. PA is the most frequent form of secondary hypertension and has been estimated to affect 5-15% of hypertensive patients [3][4][5]. Moreover, the prevalence of PA has been found to correlate with the severity of hypertension [6,7], and patients with PA are at higher risk for cardiovascular events than those with essential hypertension [8][9][10] Abstract. Primary aldosteronism (PA) is associated with a higher rate of cardiovascular events than essential hypertension. Although adrenalectomy has been reported to reduce carotid intima-media thickness (IMT) in patients with PA, the effects of the selective aldosterone blocker, eplerenone, on vascular damage in these patients remains unclear. To evaluate the effects of eplerenone on vascular status in PA patients, we sequentially measured carotid IMT (using computer software to calculate an average IMT for accurate and reproducible evaluation) in 22 patients including 8 patients treated by unilateral adrenalectomy and 14 patients treated with eplerenone for 12 months. Patients who underwent adrenalectomy showed significant reductions in aldosterone concentration (from 345 ± 176 pg/mL to 67 ± 34 pg/mL; P<0.01) and IMT (from 0.67 ± 0.07 mm to 0.63 ± 0.09 mm; P<0.05) 6 months after surgery. Patients treated with eplerenone showed significant reductions in IMT from baseline (0.75 ± 0.10 mm) to 6 (0.71 ± 0.11 mm; P<0.05) and 12 (0.65 ± 0.09 mm; P<0.01) months, although plasma aldosterone level increased significantly, from 141 ± 105 pg/mL to 207 ± 98 pg/mL (P<0.05). Eplerenone treatment of patients with PA reduces blood pressure, increases serum potassium level, and improves vascular status. Carotid IMT may be a useful marker for evaluating the effectiveness of eplerenone in patients with PA.

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“…IMT is considered a surrogate marker for atherosclerosis and a strong predictor of future cardiovascular events [29][30][31]. However, many methods are used to measure IMT.…”

Section: Discussionmentioning

confidence: 99%

Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism

et al. 2016

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“…Other issues associated with carotid ultrasonography protocols, namely the region used for the measurement of the different carotid segments (CCA, BIF, and ICA) and the use of the mean or maximal IMT, should also be discussed. Although several cohort studies have shown that the carotid IMT values measured at all of the segments (CCA, BIF, and ICA) predict future cardiovascular events to nearly the same events, the addition of the carotid IMT to traditional vascular risk prediction models did not significantly increase the performance of the models 23,24) . Therefore, the 2013 ACC/AHA guidelines stated that routine carotid IMT measurement is not recommended in clinical practice for the risk assessment of the first cardiovascular event 25) .…”

Section: Introductionmentioning

confidence: 99%

Carotid Intima-Media Thickness for Atherosclerosis

Nezu

Hosomi

Aoki

et al. 2016

J Atheroscler Thromb

254

201

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“…Through a paracrine effect, the Tie is a type of highly homologous tyrosine kinase receptor and its gene location is in 9p21, encoding the 22 amino acids [11]. Ang-1 combine with Tie-2 to be a polymer formation, and then induced the Tie-2 itself phosphorylation and activation, which was through the PIP3/AKT signal pathways to regulate/apoptosis of endothelial cell proliferation, regulating the endothelial cells of budding, migration, chemotaxis and aggregation, etc [12][13][14][15]. In the study, the level of ang-1, tie-2 and VCAM-1 were 585.04 ± 45.32 (pg/ml), 2399.40 ± 124.85 (pg/ml) and 117.69 ± 12.34 (µg/L) in the diabetes groups which were higher than that in control groups 551.29 ± 31.86 (pg/ml), 2103.27 ± 152.89 (pg/ml) and 93.43 ± 10.48 (µg/L), P<0.05, has different statistically significance.…”

Section: Discussionmentioning

confidence: 99%

Pathologic changes of pancreatic endothelial cells in Diabetic Rat

Wu¹,

Wang²,

Shao³

et al. 2017

J Clin Exp Cardiolog

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Aim: The study is to explore the relationship between pancreas endothelial cell injury and diabetes. Methods:To induce with a single intraperitoneal injection of streptozotocin (STZ) for diabetic animal models, and collected the blood after 8 weeks, the level of Angiogenin-1 (Ang-1) and its receptor (Tie-2), vascular cell adhesion molecule-1 (VCAM-1) were determinated by ELISA method, histopathological examination of the pancreas, and observed pathological conditions of the pancreas endothelial cell injury in the models.Results: The results showed that the level of ang-1, tie-2 and VCAM-1 were 585.04 ± 45.32 (pg/ml), 2399.40 ± 124.85 (pg/ml), 117.69 ± 12.34 (µg/L) in the Diabetes groups which were higher than that in control groups 551.29 ± 31.86 (pg/ml), 2103.27 ± 152.89 (pg/ml) and 93.43 ± 10.48 (µg/L), (t=3.78, 3.52, 7.52, P<0.05). Conclusion:The Vascular endothelial cell factors of e NOS, VCAM-1, SMA, VEGFR and ICAM-1 were higher expressed in Diabetes mellitus rats than that in the normal control groups. We found that there is a certain correlation between the development of pancreatic endothelial cells and the development of diabetes, and the treatment of diabetes can provide some ideas for the future.

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Carotid intima-media thickness for cardiovascular risk assessment: Systematic review and meta-analysis

Cited by 257 publications

References 61 publications

Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism

Eplerenone improves carotid intima-media thickness (IMT) in patients with primary aldosteronism

Carotid Intima-Media Thickness for Atherosclerosis

Pathologic changes of pancreatic endothelial cells in Diabetic Rat

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