Carotid intima‐media thickness: correlation with the British Regional Heart Study risk score

Geroulakos, George; O'gorman, D. J.; Nicolaides, A.; Sheridan, Desmond J.; Elkeles, R.S.; Shaper, A. G.

doi:10.1111/j.1365-2796.1994.tb01099.x

Cited by 58 publications

(44 citation statements)

References 6 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Furthermore, a positive relationship between IMT and risk scores was also reported for the British Heart Study, Framingham, and EPOZ risk scores. [41][42][43] However, these studies concerned general populations, ie, subjects who were on average at a relatively low risk for cardiovascular disease, whereas the present study was conducted in a population at high risk. Our findings indicate that the associations of IMT and distensibility with cardiovascular risk also apply to high-risk populations.…”

Section: Discussionmentioning

confidence: 98%

Common Carotid Intima-Media Thickness and Arterial Stiffness

et al. 1999

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for the SMART Study GroupBackground-Common carotid intima-media thickness (IMT) and distensibility are markers of structural and functional vessel wall properties. Both parameters have been found in population-based studies to be associated with cardiovascular risk factors and prevalent cardiovascular disease. We investigated cross-sectionally whether IMT and distensibility are associated with cardiovascular risk in patients who already have vascular disease or atherosclerotic risk factors and evaluated the diagnostic ability of IMT and distensibility to discriminate between low-and high-risk patients. Methods and Results-IMT and distensibility (change of diameter) of the left and right common carotid arteries were measured in the first 570 patients (537 for distensibility) enrolled in the Second Manifestations of ARTerial disease (SMART) study, a cohort study among patients with a manifestation of vascular disease or cardiovascular risk factors. Three risk scores were used to classify each patient's vascular risk. Areas under the curve (AUCs) of receiver-operating characteristic curves were calculated for IMT and distensibility after the patients were dichotomized on the median of the risk scores as the outcome. Risk scores increased nearly linearly with increasing IMT and decreasing distensibility. The AUCs for IMT predicting high-risk patients were 0.77, 0.73, and 0.77 based on the 3 risk scores. The AUCs for distensibility were 0.65, 0.62, and 0.66. Conclusions-Common carotid IMT and distensibility are clear markers of cardiovascular risk in patients who already have vascular disease or atherosclerotic risk factors. IMT appears to discriminate between low-and high-risk patients better than distensibility. (Circulation. 1999;100:951-957.)

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Section: Discussionmentioning

confidence: 98%

Common Carotid Intima-Media Thickness and Arterial Stiffness

et al. 1999

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“…1 These useful surrogate markers of cardiovascular disease can now be measured noninvasively by high-resolution B-mode ultrasound. [2][3][4][5][6][7][8][9][10] Reports have shown close associations between these parameters and conventional cardiovascular risk factors, including type 2 diabetes, hypertension, obesity, dyslipidemia, and smoking. [11][12][13][14][15][16][17] Impaired endothelium-mediated regulation of vascular tone has been associated with the presence of coronary atherosclerotic lesions 2,3 and has been observed in patients with traditional cardiovascular risk factors, even in the absence of atherosclerotic lesions.…”

mentioning

confidence: 99%

“…4 Recent studies have reported that endothelial dysfunction is a predictor of cardiovascular events. 5,6 Similarly, increases in the carotid intima-media thickness (IMT) are closely associated with cardiovascular disease 7,8 and predictive of cardiovascular risk. 9 Type 2 diabetes is closely associated with microvascular and macrovascular disease, the major causes of morbidity and mortality in these patients.…”

mentioning

confidence: 99%

Deleterious Impact of “High Normal” Glucose Levels and Other Metabolic Syndrome Components on Arterial Endothelial Function and Intima-Media Thickness in Apparently Healthy Chinese Subjects: The CATHAY Study

Thomas

Chook

Qiao

et al. 2004

ATVB

106

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Objective-Endothelial vasodilator dysfunction and carotid intima-media thickening are useful surrogate markers of cardiovascular disease, a major cause of morbidity and mortality in type 2 diabetic patients. However, because most studies reporting the relationships between endothelial function, intima-media thickness (IMT), and hyperglycemia have compared diabetic patients with healthy controls, we report their relationship with glycemia as a continuum. Methods and Results-Brachial artery endothelial function (flow-mediated dilatation [FMD]) and carotid IMT were measured noninvasively by high-resolution ultrasound B-mode imaging in 228 apparently healthy Chinese subjects recruited from Hong Kong and Macau. FMD and IMT were significantly associated with increasing levels of glycemia, particularly in the "high normal" glycemic range, with IMT increasing and endothelium-independent dilatation decreasing linearly across the glucose tertiles, and endothelium-dependent dilatation significantly lower in the upper glucose tertile compared with the other 2 groups (PϽ0.01). Using multiple linear regression, fasting glucose level was identified as an independent predictor of each of these markers of vascular function (PϽ0.004). Additionally, other conventional cardiovascular risk factors, including obesity, blood pressure, and an adverse lipid profile, were also related to levels of glycemia (PϽ0.05), further contributing to impaired vascular function. Conclusion-Increasing levels of glycemia and the coexistence of other cardiovascular risk factors in apparently healthy subjects are adversely associated with arterial endothelial dysfunction and intima-media thickening. Key Words: epidemiology Ⅲ atherosclerosis Ⅲ diabetes mellitus Ⅲ hypertension Ⅲ lipids T he endothelium plays a major role in the regulation of vascular tone and in the prevention of atherogenesis. Endothelial damage and thickening of the intima-media layers are early events in the atherosclerotic process. 1 These useful surrogate markers of cardiovascular disease can now be measured noninvasively by high-resolution B-mode ultrasound. [2][3][4][5][6][7][8][9][10] Reports have shown close associations between these parameters and conventional cardiovascular risk factors, including type 2 diabetes, hypertension, obesity, dyslipidemia, and smoking. 11-17 Impaired endothelium-mediated regulation of vascular tone has been associated with the presence of coronary atherosclerotic lesions 2,3 and has been observed in patients with traditional cardiovascular risk factors, even in the absence of atherosclerotic lesions. 4 Recent studies have reported that endothelial dysfunction is a predictor of cardiovascular events. 5,6 Similarly, increases in the carotid intima-media thickness (IMT) are closely associated with cardiovascular disease 7,8 and predictive of cardiovascular risk. 9 Type 2 diabetes is closely associated with microvascular and macrovascular disease, the major causes of morbidity and mortality in these patients. 18 However, interventions that lower glyc...

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“…Thomas et al (2002) reported that many patients with SLE are likely to have asymptomatic atheromatous vascular disease. In the study of 175 women, 40% had focal plaques identified in their carotid arteries by Bmode ultrasound (Manzi et al, 1999), which are often associated with atheroma in other vascular beds, especially the coronary arteries (Frcs et al, 1994;Chambless et al, 1997). The high risk of coronary artery disease complications associated with SLE after adjustment for conventional risk factors had led to the suggestion that SLE itself is an independent cardiovascular risk factor (Urowitz and Gladman, 2000).…”

Section: Discussionmentioning

confidence: 99%

Relationship between Fetuin-A and Systemic Lupus Erythematosus as a Predictor Marker for Atherosclerosis

M.¹

2012

American Medical Journal

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Problem statement:Associations between serum levels of fetuin-A, C3 complement, calcium × phosphate product and calcification risk index and lipid profile in SLE patients were established. However, the mechanism of accelerated atherosclerosis accompanied with SLE remains elusive. We therefore turned to investigate the association between Fetuin-A, disease activity and accelerated atherosclerosis in patients with SLE. Approach: Serum blood samples were taken from 100 female SLE patients. All Patient samples were analyzed by ELISA for determination of Fetuin-A level. Calcium, Phosphate, C3 compelement, Lipid profile, Creatinine and urea were measured also in SLE patients compared with healthy control volunteers. Results: We found that Serum fetuin-A had been positively associated with carotid arterial stiffness, independent of known atherogenic factors in healthy subjects. Furthermore, Fetuin-A was correlated negatively with IMT, SLEDAI, CRI, CaxP product, Triglycerdies, VLDL and LDL. While it was correlated positively with C3 complement. Conclusion: Fetuin-A deficiency accompanied with increasing levels of calcium and phosphate gave an evidence that there was a key role of fetuin-A as a strong inhibitor of Cardio Vascular Calcification (CVC) by formation of a complex called (calciprotein) with calcium and phosphate in blood stream. So, Identification of biologic markers of disease activity associated with atherosclerosis may help to optimize therapy for this important manifestation of systemic autoimmune disease.

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Carotid intima‐media thickness: correlation with the British Regional Heart Study risk score

Abstract: It is concluded that the IMT may be a useful surrogate end-point or biological marker of coronary artery disease and might be considered for use in prospective studies and clinical trials.

Cited by 58 publications

References 6 publications

Common Carotid Intima-Media Thickness and Arterial Stiffness

Common Carotid Intima-Media Thickness and Arterial Stiffness

Deleterious Impact of “High Normal” Glucose Levels and Other Metabolic Syndrome Components on Arterial Endothelial Function and Intima-Media Thickness in Apparently Healthy Chinese Subjects: The CATHAY Study

Relationship between Fetuin-A and Systemic Lupus Erythematosus as a Predictor Marker for Atherosclerosis

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