Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings

Amato, Mauro; Montorsi, Piero; Ravani, A.; Oldani, E.; Galli, Stefano; Ravagnani, Paolo; Tremoli, Elena; Baldassarre, Damiano

doi:10.1093/eurheartj/ehm244

Cited by 174 publications

(119 citation statements)

References 58 publications

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“…However, in most analyses SAD was more robustly associated to IMT and PWV compared to WC. There were also significant associations between both abdominal obesity and inflammatory markers, as well as between 10 inflammatory markers and markers of subclinical organ damage. Interestingly, inflammatory markers were associated to PWV but not to IMT.…”

Section: Discussionmentioning

confidence: 92%

“…In addition, in view of its correlation with coronary atherosclerosis and its capacity to predict incident coronary events, carotid IMT has been proposed as a surrogate marker of coronary atherosclerosis (10). Also pulse wave velocity (PWV) measured by tonometry provides a noninvasive estimate of arterial stiffness and is an independent predictive risk factor for all-cause mortality and cardiovascular mortality (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes

Dahlén

Tengblad

Länne

et al. 2014

Diabetes & Metabolism

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SummaryAim:The aim of this study was to explore associations between abdominal obesity, inflammatory markers, and subclinical organ damage in 740 patients with type 2 diabetes. Methods:Waist circumference (WC) and sagittal abdominal diameter (SAD) was measured. Blood samples were analyzed for; C-reactive protein (CRP) and IL-6. Carotid intima-media thickness (IMT) was evaluated by ultrasonography. Aortic pulse wave velocity (PWV) was measured with applanation tonometry. Results:Abdominal obesity measured as SAD and WC were significantly correlated with; IL-6 (WC r=0.27, p<0.001, SAD r=031, p<0.001 ), CRP (WC r=0,29, p <0.001, SAD r=0,29, p <0.001), IMT (WC r=0.09 p=0.013, SAD r=0.11, p=0.003) and PWV (WC r=0.18, p<0.001, SAD r=0.21, p <0.001). In multiple linear regressions with IMT or PWV as dependent variable and age, sex, statins, systolic blood pressure (SBP), Body Mass Index (BMI), CRP and HbA1c, as independent variables, both SAD and WC, remained associated with IMT and PWV. In stepwise linear regression, entering both SAD and WC, the association between SAD and PWV was stronger than the association between WC and PWV. Conclusion:We conclude that SAD and WC are feasible measures of obesity that provides information on inflammation, atherosclerosis and arterial stiffness in type 2 diabetes. However, SAD was slightly more robustly associated to subclinical organ damage, compared with WC.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes

Dahlén

Tengblad

Länne

et al. 2014

Diabetes & Metabolism

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“…18) However, cardiovascular events are not determined only by increased carotid IMT, as 75% of thrombi in the carotid are caused by rupture, and 30% to 35% of coronary thrombi are caused by erosion. 19) The correlation between carotid IMT and future cardiac events remains modest at best, 20) but carotid atherosclerosis estimated by B-mode ultrasound is still a valuable predictor of myocardial infarction as a simple, noninvasive approach. 21) Clinically, increasing attention has been paid to carotid IMT.…”

Section: Discussionmentioning

confidence: 99%

Cholesterol and Triglyceride Concentrations in Lipoproteins as Related to Carotid Intima-Media Thickness

Takahashi¹,

Taguchi²,

Suzuki³

et al. 2012

Int. Heart J.

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SummarySince distinct cholesterol and triglyceride concentrations in major lipoproteins and their subclasses may be related to atherosclerosis, we investigated the relationship of cholesterol and triglyceride concentrations in lipoprotein subclasses and the severity of carotid intima-media thickness (IMT), a surrogate marker of subclinical atherosclerosis. We studied 116 apparently healthy Japanese men (53 ± 9 years) without a history of cardiovascular diseases who were not taking any medication. Carotid IMT was measured by means of high-resolution vascular ultrasound. Plasma cholesterol and triglyceride concentrations in major lipoproteins and their subclasses were determined by HPLC with gel permeation columns. By univariate analyses, carotid IMT was the most closely related to age (r = 0.528, P < 0.001), followed by smoking habit expressed as pack-year cigarette consumption (r = 0.409, P < 0.001). In addition to total cholesterol and LDL cholesterol, carotid IMT was significantly associated with cholesterol and triglyceride concentrations in several LDL and VLDL subclasses. Stepwise multiple linear regression analysis revealed that age (β = 0.436, P < 0.001), smoking (pack-years) (β = 0.225, P = 0.007), and large LDL cholesterol (β = 0.175, P = 0.023) were independent predictors of determining carotid IMT (adjusted R 2 = 0.347, P < 0.001). These results indicate that large LDL cholesterol is an important, independent determinant of carotid IMT in healthy men. (Int Heart J 2012; 53: 29-34) Key words: Intima-media thickness, Lipoprotein, Large low-density lipoprotein cholesterol, High-performance liquid chromatography, Carotid artery T he plasma lipid profile is the most important indicator of risk for cardiovascular disease and stroke. Several components have been proposed as atherogenic lipids and lipoproteins, including low-density lipoprotein (LDL) cholesterol, apolipoprotein B, non-high-density lipoprotein (HDL) cholesterol, triglycerides, and small dense LDL.1,2) Low HDL cholesterol concentrations have gained notice for potentially increasing risk and promoting the development of atherosclerosis. Among plasma lipids, LDL still accounts for the bulk of clinical attention for the prevention of cardiovascular diseases. 3)However, lipoproteins are a heterogeneous group of particles that differ in terms of their physicochemical properties and biological behaviors. Increasingly, attempts have been made to improve evaluation by considering particular subfractions of plasma lipids, in particular LDL and HDL subclasses of atherogenic lipids and lipoproteins. 4) Recently, high-performance liquid chromatography (HPLC) with a gel permeation column has been established as an alternative method for classifying and quantifying lipoproteins on the basis of differences in particle size. 5,6) Intima-media thickness (IMT) in the carotid arteries, measured with high-resolution ultrasonography, is currently the standard clinical marker and a quantitative measure of atherosclerosis; a graded, predictive relationship to over...

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“…Numerous studies from around the world have demonstrated that there is a strong correlation between the risk of cerebrovascular diseases and the characteristics of the carotid artery wall [1][2][3]. Ultrasound examination is a widely used diagnostic tool for assessing and monitoring the plaque buildup via the carotid window.…”

Section: Introductionmentioning

confidence: 99%

CAUDLES-EF: Carotid Automated Ultrasound Double Line Extraction System Using Edge Flow

et al. 2011

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The evaluation of the carotid artery wall is essential for the diagnosis of cardiovascular pathologies or for the assessment of a patient's cardiovascular risk. This paper presents a completely user-independent algorithm, which automatically extracts the far double line (lumenintima and media-adventitia) in the carotid artery using an Edge Flow technique based on directional probability maps using the attributes of intensity and texture. Specifically, the algorithm traces the boundaries between the lumen and intima layer (line one) and between the media and adventitia layer (line two). The Carotid Automated Ultrasound Double Line Extraction System based on Edge-Flow (CAUDLES-EF) is characterized and validated by comparing the output of the algorithm with the manual tracing boundaries carried out by three experts. We also benchmark our new technique with the two other completely automatic techniques (CALEXia and CULEXsa) we previously published. Our multi-institutional database consisted of 300 longitudinal Bmode carotid images with normal and pathologic arteries. We compared our current new method with previous methods, and showed the mean and standard deviation for the three methods: CALEXia, CULEXsa, and CAUDLES-EF as 0.134±0.088, 0.074±0.092, and 0.043±0.097 mm, respectively. Our IMT was slightly underestimated with respect to the ground truth IMT, but showed a uniform behavior over the entire database. Regarding the Figure of Merit (FoM), CALEXia and CULEXsa showed the values of 84.7% and 91.5%, respectively, while our new approach, CAUDLES-EF, performed the best at 94.8%, showing a good improvement compared to previous methods.

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Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings

Abstract: Carotid atherosclerosis correlates better with coronary atherosclerosis when both circulations are investigated by the same technique (ultrasound) using the same parameter (IMT). This supports the concept that carotid IMT is a good surrogate marker of coronary atherosclerosis.

Cited by 174 publications

References 58 publications

Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes

Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes

Cholesterol and Triglyceride Concentrations in Lipoproteins as Related to Carotid Intima-Media Thickness

CAUDLES-EF: Carotid Automated Ultrasound Double Line Extraction System Using Edge Flow

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