Carotid Intima Media Thickness, Atherosclerosis, and 5-Year Decline in Odor Identification: The Beaver Dam Offspring Study

Schubert, Carla R.; Cruickshanks, Karen J.; Fischer, Mary; Huang, Guan; Klein, Ronald; Tsai, Michael Y.; Pinto, Alex

doi:10.1093/gerona/glu158

Cited by 31 publications

(63 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This search did identify one longitudinal study, which found current and former smokers to be at elevated risk of decline in olfactory performance, with a stronger association among current smokers . Our own prior longitudinal examination of olfactory decline also found no effect of smoking status .…”

Section: Discussionmentioning

confidence: 91%

Smoking and olfactory dysfunction: A systematic literature review and meta‐analysis

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 91%

Smoking and olfactory dysfunction: A systematic literature review and meta‐analysis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The overall rate reported for NHANES 2012 is higher than the prevalence of 3.8 % ( n = 2838) reported in the Beaver Dam Offspring Study [12, 58] for younger participants, aged 21 to 84 years (mean age = 49 years), which utilized a technician-administered odor identification task, but less than the 19.1 % ( n = 1387) for the Skövde population-based study [16] of subjects aged 20+ years, which also was technician-administered, the 22.1 % ( n = 1277) for Dortmund Health Study [59] of subjects aged 25 to 75 years, which used an odor identification task, and the 20 % ( n = 10,783) from the OLFACAT study [60] of subjects aged 15+ years, which used a combined newspaper-solicited survey and self-administered procedures.…”

Section: Discussionmentioning

confidence: 95%

New chemosensory component in the U.S. National Health and Nutrition Examination Survey (NHANES): first-year results for measured olfactory dysfunction

Hoffman

Rawal

et al. 2016

Rev Endocr Metab Disord

173

255

View full text Add to dashboard Cite

The U.S. NHANES included chemosensory assessments in the 2011–2014 protocol. We provide an overview of this protocol and 2012 olfactory exam findings. Of the 1818 NHANES participants aged ≥40 years, 1281 (70.5 %) completed the exam; non-participation mostly was due to time constraints. Health technicians administered an 8-item, forced-choice, odor identification task scored as normosmic (6–8 odors identified correctly) versus olfactory dysfunction, including hyposmic (4–5 correct) and anosmic/severe hyposmic (0–3 correct). Interviewers recorded self-reported smell alterations (during past year, since age 25, phantosmia), histories of sinonasal problems, xerostomia, dental extractions, head or facial trauma, and chemosensory-related treatment and changes in quality of life. Olfactory dysfunction was found in 12.4 % (13.3 million adults; 55 % males/45 % females) including 3.2 % anosmic/severe hyposmic (3.4 million; 74 % males/26 % females). Selected age-specific prevalences were 4.2 % (40–49 years), 12.7 % (60–69 years), and 39.4 % (80+ years). Among adults ≥70 years, misidentification rates for warning odors were 20.3 % for smoke and 31.3 % for natural gas. The highest sensitivity (correctly identifying dysfunction) and specificity (correctly identifying normosmia) of self-reported olfactory alteration was among anosmics/severe hyposmics (54.4 % and 78.1 %, respectively). In age- and sex-adjusted logistic regression analysis, risk factors of olfactory dysfunction were racial/ethnic minority, income-to-poverty ratio ≤ 1.1, education

show abstract

“…However, smoking may also affect olfaction through its effects on the vascular system [67] as well, or via effects on the brain.…”

Section: Risk Factors That Have Been Associated With Olfactory Disordersmentioning

confidence: 99%

“…In age- and sex-adjusted models, the mean intima media thickness (OR 1.17, 95%CI 1.01–1.34, per 0.1 mm) and the number of sites (range 0–6) with carotid artery plaque (OR 1.35, 95%CI 1.11–1.65, per site) at baseline were associated with an increased risk for decline. The plaque score (OR 1.24, 95%CI 1.01–1.53) was a significant independent predictor of olfactory decline in a multivariate model [67] . Pinto et.…”

Section: Risk Factors That Have Been Associated With Olfactory Disordersmentioning

confidence: 99%

The Epidemiology of Olfactory Disorders

Yang

Pinto

2016

Curr Otorhinolaryngol Rep

View full text Add to dashboard Cite

Insights into risk factors for olfactory decline are needed, because knowledge about its origin is limited. This impairment has important implications for human health. Several epidemiologic studies of olfaction provide insight into the prevalence of olfactory disorders. Here, we review the major population studies carried out on this topic to date. Our purpose is to characterize knowledge about olfactory disorders from human studies. We also describe the existing methods for measuring the sense of smell in population studies, present recent insights into the epidemiology of smell disorders, and discuss the risk factors identified to date. Synthesis of these data shows that olfactory dysfunction increases as people age and is worse in men. Further study of olfaction is warranted for gaining better information on the etiologies affecting its impairment, research that will have a large public health impact.

show abstract

Carotid Intima Media Thickness, Atherosclerosis, and 5-Year Decline in Odor Identification: The Beaver Dam Offspring Study

Abstract: Subclinical atherosclerosis was associated with an increased risk for olfactory decline indicating that atherosclerosis may be one of the risk factors for the decline in olfactory function seen with aging. Strategies to improve vascular health may also benefit olfactory health.

Cited by 31 publications

References 35 publications

Smoking and olfactory dysfunction: A systematic literature review and meta‐analysis

Smoking and olfactory dysfunction: A systematic literature review and meta‐analysis

New chemosensory component in the U.S. National Health and Nutrition Examination Survey (NHANES): first-year results for measured olfactory dysfunction

The Epidemiology of Olfactory Disorders

Contact Info

Product

Resources

About