Carotid Intima-Media Thickness as the Cardiometabolic Risk Indicator in Patients with Nonfunctional Adrenal Mass and Metabolic Syndrome Screening

Abstract

BackgroundOur purpose was to show the association of adrenal incidentaloma and metabolic syndrome in consideration of the studies and to detect the increase in the carotid intima-media thickness which is regarded as the precessor of atherosclerosis.Material/MethodsEighty-one patients who were diagnosed with adrenal mass were included in the study. Hormonal evaluation, insulin rezistance measurement with the HOMA-IR and 1-mg DST were performed of all patients. The patients were classified as follows: mass size <3 cm (K1) and mass size of at least 3 cm (K2). Echocardiography and carotid intima-media thickness of the patients were measured using B-mode ultrasound. Thirty-three healthy individuals were enrolled as the control group.ResultsMass size of 64.19% K1, while mass size of the remainder (35.81%) K2 was calculated. Five of the patients with adrenal mass were detected to have subclinical Cushing syndrome. The remaining 76 patients were accepted as nonfunctional. It was seen with regard to metabolic and biochemical parameters that plasma glucose (p=0.01), insulin (p=0.00) and triglyceride (p=0.012) values of all patients were significantly high compared to those of the control group. It was detected that measured heart rate (p=0.00), end-diastolic diameter (p=0.02), end-systolic diameter (p=0.014) and carotid intima-media thickness (p=0.00) values of the patients with adrenal mass were significantly higher than those of the healthy control group.ConclusionsWe found that the increased insulin resistance, increased risk of cardiovascular disease with the increase in the thickness of carotid intima-media and diastolic disfunction parameters, although the patients with adrenal incidentaloma are nonfunctional.

Nonfunctioning adrenal incidentaloma: A novel predictive factor for metabolic syndrome

“…Some studies have also demonstrated higher frequencies of metabolic syndrome components in NFAI patients . In this context, our results are in line with previous reports, which have demonstrated increased frequency of glucose and lipid disturbances and arterial hypertension.…”

“…Despite the growing number of studies evidencing a higher frequency of these isolated components of metabolic syndrome in the NFAI population, [18][19][20][21][22][23] it has been assumed this is the first clinical study to evaluate and classify patients with NFAI by different Some studies have also demonstrated higher frequencies of metabolic syndrome components in NFAI patients. [18][19][20][21][22][23] In this context, our results are in line with previous reports, which have demonstrated increased frequency of glucose and lipid disturbances and arterial hypertension. In a multicenter urban Brazilian population study, the prediabetes rate in the 60-to 69-year-old group was 11.2%.…”

“…In the present study, patients with NFAI presented a higher frequency of all criteria for metabolic syndrome (hypertension, hyperglycaemia, dyslipidaemia, increased waist circumference) and a greater metabolic syndrome frequency by four different classifications compared to controls. Despite the growing number of studies evidencing a higher frequency of these isolated components of metabolic syndrome in the NFAI population, it has been assumed this is the first clinical study to evaluate and classify patients with NFAI by different metabolic syndrome criteria defined by globally recognized institutions, and to compare them to controls with normal adrenal imaging.…”

Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas

“…Retrospective analysis unexpectedly revealed that also asymptomatic patients with adrenal adenomas and low-grade autonomous cortisol secretion suffer from a higher rate of CV events and mortality than patients with normal HPA axis suppression (5,6,7). Despite these epidemiological associations, only two small studies investigated morphological and functional changes to the CV system in patients with mild hypercortisolism (8,9). In particular, they did not investigate whether CV changes correlated to cortisol levels.…”

Effects of Active Components of Fuzi and Gancao Compatibility on Bax, Bcl‐2, and Caspase‐3 in Chronic Heart Failure Rats

“…For example, it can measure the thickness of ventricular wall and carotid intima-media, which are risk factors of cardiovascular diseases. And we know that heart failure is a state of most cardiovascular diseases [30, 31]. So in this research, we selected the transthoracic echocardiography for evaluations of cardiac functions.…”