Carotid Intima Media Thickness as a Measure of Cardiovascular Disease Burden in Nigerian Africans with Hypertension and Diabetes Mellitus

Okeahialam, Basil N; Alonge, B.; Pam, Sunday; Puepet, FH

doi:10.1155/2011/327171

Cited by 19 publications

(19 citation statements)

References 21 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study demonstrates that patients with diabetes have significantly higher CIMT compared to apparently healthy individuals. Although this finding conforms to reports from other parts of Nigeria and the world [12,18], measured CIMT among the diabetics in our study is much higher. Plausible explanation for this variation includes differences in sample sizes, duration of diabetes, differences in demographics, co morbidities, method of measuring CIMT and levels of glycaemic control.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Carotid Intima-Media Thickness in Patients with Diabetes Mellitus Attending Tertiary Care Hospital in Nigeria

Baba¹,

Talle²,

Ibinaiye³

et al. 2018

Angiol

View full text Add to dashboard Cite

Objective: Carotid intima-media thickness is a significant and independent predictor of coronary artery disease in patients with diabetes. The aim of our study was to determine carotid intima-media thickness in Nigerians with diabetes. Methods:This was an observational cross-sectional study involving consecutively presenting patients with type 2 diabetes mellitus and healthy age-matched adults. Anthropometric variables were measured, and blood samples collected for fasting blood sugar, cholesterol, and HbA1c. Carotid intima-media thickness was measured using a 2-D scanner. Association of carotid intima-media thickness with other variable was assessed using correlation and multivariable linear regression models. Results:One hundred and fifty two subjects (87 diabetics and 65 healthy adults) were studied. Carotid intimamedia thickness was significantly higher among diabetics. Seventy nine (90.8%) and seventy two (82.8%) patients with diabetes had carotid intima-media thickness greater than 0.9 mm and 1.0 mm respectively. Carotid intimamedia thickness was higher in patients with higher HbA1c, fasting blood sugar, body mass index, total cholesterol and LDL cholesterol, and significantly correlated with HbA1c, age, fasting blood sugar, systolic blood pressure, total cholesterol, LDL-c and HDL-c. Age, HbA1c and duration of hypertension predicted increased carotid intima-media thickness. Conclusion:The prevalence of increased carotid intima-media thickness is extremely high among Nigerians with diabetes, and this significantly correlated with other risk factors for cardiovascular diseases. Assessment of carotid intima-media thickness should be routinely included in evaluation of subjects with diabetes, and assessment of total cardiovascular risk.

show abstract

Section: Discussionsupporting

confidence: 90%

“…Diabetes have been associated with increased CIMT, and this has been linked to increased cardiovascular events in Caucasians and Asians with type 2 diabetes mellitus (T2DM) [9][10][11]. Among the patients studied in Jos (central Nigeria), CIMT was found to be higher among diabetics than the non-diabetics [12].…”

Section: Introductionmentioning

confidence: 99%

Carotid Intima-Media Thickness in Patients with Diabetes Mellitus Attending Tertiary Care Hospital in Nigeria

Baba¹,

Talle²,

Ibinaiye³

et al. 2018

Angiol

View full text Add to dashboard Cite

show abstract

“…Heterogeneity in the methods used by different studies at the site of measurement of carotid artery IMT could account for this variation. In this study, measurement of the CIMT in the longitudinal and the transverse planes was employed, and the average of these 2 planes was used as a single CIMT value for each side, similar to previous studies by Casella et al and Okeahialam et al The anterolateral and posterolateral planes, in relation to the sternocleidomastoid muscle, were used for the longitudinal measurement due to clarity and easy accessibility to the CCA, as supported by Casella et al…”

Section: Discussionmentioning

confidence: 95%

Variation of Carotid Intima Media Thickness With Body Mass Index in Healthy Adults of Black African Descent

Asaleye

Braimoh

Oyinloye

et al. 2018

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

“…Using B-mode ultrasonography, Okeahialam et al 28. found a non-significant increase in carotid intima media thickness (IMT) among hypertensive and diabetic patients in Jos, central Nigeria.…”

Section: Discussionmentioning

confidence: 99%

Stroke risk factors, subtypes, and 30-day case fatality in Abuja, Nigeria

et al. 2013

View full text Add to dashboard Cite

Background:Stroke is the second leading cause of death and the leading cause of adult disability worldwide. A better understanding of stroke risk factors and outcome may help guide efforts at reducing the community burden of stroke. This study aimed to understand stroke risk factors, imaging subtypes, and 30-day outcomes among adult Nigerians.Materials and Methods:We prospectively recruited all patients presenting with acute stroke at the National Hospital Abuja between January 2010 and June 2012. We assessed clinical and laboratory variables, as well as brain computerized tomography, magnetic resonance imaging, and carotid Doppler ultrasound scans. We also assessed case fatality and functional outcome at 30 days after stroke.Results:Of 272 patients studied, 168 (61.8%) were males. Age at presentation (mean ± standard deviation) was 56.4 ± 12.7 years in males and 52.9 ± 14.8 years in females (P = 0.039). Neuroimaging was obtained in 96.7% patients, revealing cerebral infarction (61.8%), intracerebral hemorrhage (ICH) (34.8%), and subarachnoid hemorrhage (SAH) (3.4%). Carotid plaques or stenosis ≥50% were detected in 53.2% patients with cerebral infarction. Stroke risk factors included hypertension (82.7%), obesity (32.6%), diabetes (23.5%), hyperlipidemia (18.4%), atrial fibrillation (9.2%), and cigarette smoking (7.7%). At 30 days after stroke, case-fatality rate was 18.8%, whereas modified Rankin Scale (mRS) scores for cerebral infarction, ICH, and SAH were 3.71, 4.21, and 4.56, respectively. Atrial fibrillation, a previous stroke, and age older than 50 years were all associated with worse mRS scores at 30 days.Conclusion:Although hypertension, obesity, diabetes mellitus, and atrial fibrillation were important stroke risk factors, in many patients, these were detected only after a stroke. While the commonest stroke subtype was cerebral infarction, observed in almost two-third of patients, SAH was associated with the highest case-fatality rate at 30 days of 44.4%. Larger population-based studies may provide additional data on stroke incidence and outcome among Nigerians.

show abstract

Carotid Intima Media Thickness as a Measure of Cardiovascular Disease Burden in Nigerian Africans with Hypertension and Diabetes Mellitus

Cited by 19 publications

References 21 publications

Carotid Intima-Media Thickness in Patients with Diabetes Mellitus Attending Tertiary Care Hospital in Nigeria

Carotid Intima-Media Thickness in Patients with Diabetes Mellitus Attending Tertiary Care Hospital in Nigeria

Variation of Carotid Intima Media Thickness With Body Mass Index in Healthy Adults of Black African Descent

Stroke risk factors, subtypes, and 30-day case fatality in Abuja, Nigeria

Contact Info

Product

Resources

About