Carotid intima-media thickness and coronary heart disease risk factors in a low-risk population

Ferrières, Jean; Elias, Arthur W.; Ruidavets, J.B.; Cantet, C; Bongard, Vanina; Boccalon, H

doi:10.1016/s0895-7061(99)80306-9

Cited by 13 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4,5,14 The method appears highly suited to the goal of detecting asymptomatic vascular target organ damage, which also may greatly assist with the assessment of risk and selection of appropriate, preventive strategies for the management of hypertension. Furthermore, assessment of carotid IMT is increasingly used as a surrogate end point for determining the efficacy of pharmacological interventions in large cardiovascular clinical trials, and used as an important phenotype of cardiovascular complications in the field of epidemiology and genetics in patients with hypertension.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension

et al. 2003

View full text Add to dashboard Cite

Carotid intima-media thickness (IMT) assessed by ultrasonography is regarded as an early predictor of general arteriosclerosis in patients with essential hypertension. However, the methods of measuring IMT have not been globally standardized, and it remains unclear whether conventional measurement of IMT represents the prevalence of hypertensive target organ damage. In this study, we verified the association between several commonly used carotid ultrasonographical parameters and the severity of hypertensive target organ damage (retinal arteriosclerosis, microalbuminuria, left ventricular hypertrophy (LVH)). Carotid ultrasonography, echocardiography, urinalysis, and funduscopy were performed in 184 patients (64 7 12 years, 96 males and 88 females) with various stages of essential hypertension. Carotid arteriosclerosis was assessed using four methodologically different methods: conventional-IMT, maximum-IMT (Max-IMT), Mean-IMT, and Plaque Score (the sum of all plaque thicknesses). Age and all carotid ultrasonographical parameters were significantly associated with albuminuria, retinal arteriosclerosis, and left ventricular mass index. High-sensitivity CRP was significantly correlated with retinopathy and LVH. Carotid parameters in patients with histories of cardiovascular events were significantly greater in those without events. Among all carotid parameters, Max-IMT showed the highest correlation coefficient of the severity of target organ damage, and showed significant association with CRP. Stepwise regression analysis revealed that Max-IMT was the independent factor for predicting target organ damage. Max-IMT is suggested to be the most reliable and simplest parameter for predicting hypertensive target organ damage including microangiopathy in patients with essential hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension

et al. 2003

View full text Add to dashboard Cite

show abstract

“…5,[7][8][9][22][23][24][25][26][27] In some 7,8,[22][23][24]27 but not all these studies, 25 an inverse correlation between arterial thickening and HDL-C was found. To the best of our knowledge, this is the first study examining carotid arterial thickening in individuals at the two extremities of the HDL-C distribution, ie, subjects with primary HypoALP or HyperALP, who are generally considered at high and low CAD risk, respectively.…”

Section: Discussionmentioning

confidence: 99%

Increased Carotid Artery Intima-Media Thickness in Subjects With Primary Hypoalphalipoproteinemia

Baldassarre

Amato

Pustina

et al. 2002

ATVB

View full text Add to dashboard Cite

Abstract-The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study, we evaluated pre-intrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age, and plasma cholesterol. The average and maximal intima-media thicknesses (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than in control subjects (0.94Ϯ0.06 versus 0.69Ϯ0.04 mm, Pϭ0.004, and 1.86Ϯ0.16 versus 1.35Ϯ0.10 mm, Pϭ0.025, respectively). The IMT values in HyperALP subjects (Avg-IMT, 0.71Ϯ0.04 and Max-IMT, 1.38Ϯ0.14 mm) were the same as in controls. In a large cohort of hyperlipidemic subjects (nϭ559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (Ͻ42 mg/dL) than in all the others. The measurement of carotid IMT in cases with HypoALP and HyperALP, and in a large series of hyperlipidemic patients, thus indicates that a low HDL-C is associated with significant pre-intrusive atherosclerosis, whereas a HDL-C level above average values does not lead to a further reduction of arterial wall thickening.

show abstract

“…11,12 any vascular bed (Table 1). 6,9,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Progression of carotid atherosclerosis also is influenced by concomitant risk factors (Table 2). [31][32][33][34][35][36][37] Carotid atherosclerosis is commonly found in association with coronary and peripheral atherosclerosis.…”

Section: Methodsmentioning

confidence: 99%

Surrogate Markers for Cardiovascular Disease

2004

View full text Add to dashboard Cite

Carotid intima-media thickness and coronary heart disease risk factors in a low-risk population

Cited by 13 publications

References 0 publications

Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension

Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension

Increased Carotid Artery Intima-Media Thickness in Subjects With Primary Hypoalphalipoproteinemia

Surrogate Markers for Cardiovascular Disease

Contact Info

Product

Resources

About