Carotid intima-media thickness and cardiometabolic risk factors in Pakistani type 2 diabetics

Bashir, Farhat; Nageen, Ayesha; Kidwai, Saera Suhail; Ara, Jamal

doi:10.4103/sjhs.sjhs_66_17

Cited by 6 publications

(13 citation statements)

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“…30,31,32 This would be a clinically important factor as patients with diabetes mellitus are twice as likely to die from cardiovascular causes associated with atherosclerosis as compared to the normal population. 12 The association of a high CIMT with DR warrants a complete cardiac evaluation of the diabetic patient with DR in order to rule out sub-clinical cardiovascular disease. These patients are not only at risk of losing vision due to DR but are also at a higher risk of developing catastrophic cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

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Diabetic retinopathy and its’ association with carotid intima media thickness.

Bashir

Khan

Tanveer

2019

TPMJ

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ABSTRACT… Objectives: To evaluate the association of diabetic retinopathy (DR) and CIMT (carotid intima-media thickness) in diabetic subjects and to identify the factors contributing to retinopathy. Study Design: Comparative cross-sectional study. Setting: Creek General Hospital, United Medical and Dental College. Period: August 2017 to July 2018. Material and Methods: After identification of 62 subjects with type 2 diabetes mellitus for the study, their complete history, physical examination and relevant laboratory investigations were recorded. The diabetic retinopathy was assessed by ophthalmoscopy. All subjects underwent Doppler ultrasound scanning of the carotid arteries for measurement of CIMT (carotid intima-media thickness). The data was analyzed through SPSS version 20.0. Student's t-test was used to assess the association between retinopathy and CIMT and other continuous variables. The association of categorical variables was assessed by Chi-square. P-value of <0.05 was considered significant. Results: The target population constituted 29% males and 71% females. Among the participating subjects 50.2% had retinopathy while 49.8% subjects without retinopathy were included in the study. There was a strong association of retinopathy with carotid intimamedia thickness. Retinopathy was also associated with duration of diabetes mellitus, measures of glycemic control, serum creatinine levels, total cholesterol, LDL cholesterol, and serum triglycerides. Conclusion: Retinopathy is strongly associated with CIMT. Poor glycemic control, nephropathy, dyslipidemia and duration of diabetes also show association with retinopathy.

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Section: Discussionmentioning

confidence: 99%

“…11 Increase in CIMT and presence of carotid plaques are associated with CV risk factors. 12,13 they are also used to predict CV events independently of risk factors, 14 and can help to stratify patients into different risk categories 15 thus adding more accuracy to the current risk analysis methods.…”

Section: Introductionmentioning

confidence: 99%

Diabetic retinopathy and its’ association with carotid intima media thickness.

Bashir

Khan

Tanveer

2019

TPMJ

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“…Hong et al [27] reported higher CIMT values in prehypertensives than normotensives. Bashir et al [28] reported a strong positive correlation of CIMT with systolic blood pressure (p=0.000) and a moderately positive correlation with diastolic blood pressure.…”

Section: Mugada and Kolakotamentioning

confidence: 97%

“…There is a highly significant correlation of CIMT with duration of diabetes (p<0.0001) in our study. Bashir et al [28] reported a highly significant correlation of CIMT with duration of diabetes (p=0.000). The strong relationship between CIMT with duration of diabetes reflects the detrimental effect on arterial wall thickening through ongoing (Tables 2 and 3).…”

Section: Mugada and Kolakotamentioning

confidence: 97%

“…The strong relationship between CIMT with duration of diabetes reflects the detrimental effect on arterial wall thickening through ongoing (Tables 2 and 3). One study reported no significant association of CIMT with Hb1Ac levels [28]. Few studies reported that blood pressure control was more important for all the endpoints, especially cardiovascular complications in diabetic patients as compared to the glycemic control [29,30].…”

Section: Mugada and Kolakotamentioning

confidence: 99%

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Carotid Artery Intima-Media Thickness and 10-Year Risk of Heart Disease in Diabetic Patients: A Comparative Study

Mugada

Kolakota

2019

Asian J Pharm Clin Res

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Objective: The aim of the present study was to assess the factors affecting carotid artery intima-media thickness (CIMT) and 10-year risk of heart disease in diabetic patients classified according to CIMT. Methods: This was an analytical cross-sectional study conducted on 92 patients for 1 year. 10-year risk of heart disease was calculated using the American College of Cardiology/American Heart Association Guideline on the Assessment of Cardiovascular Risk. Based on CIMT, the subjects were classified into two groups. Group 1 contains subjects with CIMT <0.9 and Group 2 contains subjects with CIMT ≥0.9. The Mann–Whitney U-test, Pearson’s correlation, and descriptive statistics were used to compare and describe the data. The level of statistical significance was taken at p<0.05. Results: Patients with 51–60 years of age group are high in number. Males were predominantly high than their counterparts. There is a statistically significant association between total cholesterol (p=0.001), high-density lipoproteins (p=0.000), low-density lipoproteins (p=0.001), postprandial blood sugar (p=0.000), and hemoglobin 1Ac (p=0.035) with CIMT. The mean 10-year risk of heart disease in Groups 1 and 2 is 13.13±15.40 and 23.63±17.57, respectively. There is statistically highly significant association (p=0.000) of 10-year risk of heart disease between two groups. There is a positive correlation (r=0.45, p<0.0001) between CIMT and risk of heart disease. Conclusion: Our study found that greater the CIMT, greater the risk of the heart of disease.

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Prevalence of anemia, associated risk factors and outcome in CHUK, Rwanda: a prospective observational study

Havugimana

Ndahimana

Babane

et al. 2023

Preprint

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Background: Admitted patients with anemia are at increased morbidity and mortality risk as well as length of hospital stay. It affects more than 2 billion people worldwide and is causing significant morbidity and mortality. Its etiology is varying with many predisposing factors including nutritional deficiencies, infections, Malignancies, chronic inflammations and other chronic diseases like autoimmune diseases, chronic liver disease, and chronic kidney disease. Methods: We performed a non-randomized, prospective observational study of 143 patients admitted in Internal Medicine between March and April 2021, we assessed their hemoglobin level in order to determine the prevalence of anemia. The demographic and clinical data were collected using a designed questionnaire. All patients found to have anemia were followed for outcome assessment (either discharge or died). Results: The prevalence of anemia was high (52.4%) among 143 admitted patients in Internal Medicine, CHUK. Patients with HIV, cancer and chronic kidney disease had 5.84-, 4.11- and 3.79-times risk of having anemia respectively. In 75 patients who had anemia 10 patients died among them 5 patients were having severe anemia; 25 patients were 60 years old and above; 60 patients had normocytic anemia and they had an average of length of hospital stay of 20.6 days, patients with severe anemia, length of hospital stay was 28 days. Conclusion: This study demonstrated a high prevalence of anemia which is associated with high mortality rate among admitted patients in CHUK. Priority should be given to the preventive medicine, optimal management of chronic disease and geriatric medicine.

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Carotid intima-media thickness and cardiometabolic risk factors in Pakistani type 2 diabetics

Cited by 6 publications

References 0 publications

Diabetic retinopathy and its’ association with carotid intima media thickness.

Diabetic retinopathy and its’ association with carotid intima media thickness.

Carotid Artery Intima-Media Thickness and 10-Year Risk of Heart Disease in Diabetic Patients: A Comparative Study

Prevalence of anemia, associated risk factors and outcome in CHUK, Rwanda: a prospective observational study

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