Carotid FDG Uptake Improves Prediction of Future Cardiovascular Events in Asymptomatic Individuals

Moon, Seung Hwan; Cho, Young Seok; Noh, Tae Soo; Choi, Joon Young; Kim, Byung‐Tae; Lee, Kyung-Han

doi:10.1016/j.jcmg.2015.06.002

Cited by 43 publications

(35 citation statements)

References 32 publications

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“…34,35 In addition, carotid artery TBR has been shown to strongly predict subsequent cardiovascular disease in patients with no previous history of cardiovascular disease independent of traditional risk factors. 36 Moreover, when we examined which variables including carotid artery SUV, venous blood SUV, and TBR value were independently associated with %FMD, TBR value was the strongest correlate of decreased %FMD (β=−2.506; P=0.002). Carotid artery SUV (β=0.295; P<0.001), %FMD (β=0.017; P<0.001), and prevalence of coronary artery disease (β=−0.125; P=0.016) were independently correlated with blood pool SUV.…”

Section: Methodological Considerationsmentioning

confidence: 99%

“…32,33 Furthermore, TBR calculated as arterial standardized uptake value (SUV) score divided by venous blood SUV is generally used as an index of a quantitative parameter of vascular inflammation. 23,[32][33][34][35][36] Indeed, Tawakol et al 23 reported that TBR values in the carotid arteries were closely correlated with accumulation of CD68-positive macrophages in the corresponding histological sections of patients with severe carotid stenoses (r=0.85; P<0.001). Carotid TBR values were higher in patients with high-risk morphological features of atherosclerotic plaques, such as echolucent plaques, positive remodeling, luminal irregularity, and low attenuation in computed tomographic, than those without.…”

Section: Methodological Considerationsmentioning

confidence: 99%

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Vascular Inflammation Evaluated by [ ¹⁸ F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction

Honda

Tahara

Nitta

et al. 2016

ATVB

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Objective— Endothelial dysfunction is an initial step in atherosclerotic cardiovascular disease. However, involvement of vascular inflammation in endothelial dysfunction is not fully investigated in humans because of the lack of diagnostic modality to noninvasively evaluate vascular inflammation. We assessed the relationship between endothelial function and vascular inflammation evaluated by [ 18 F]-fluorodeoxyglucose-positron emission tomography/computed tomographic imaging. Approach and Results— We examined endothelial function and vascular inflammation by flow-mediated dilation (FMD) of the brachial artery and [ 18 F]-fluorodeoxyglucose-positron emission tomography/computed tomographic imaging of carotid arteries, respectively, in 145 subjects (95 men and 50 women; mean age, 61.8±9.5 years) who underwent a risk-screening test for cardiovascular disease in Kurume University Hospital. Vascular inflammation was measured by blood-normalized standardized uptake value, known as a target:background ratio (TBR). We investigated whether absolute changes from baseline of %FMD after antihypertensive treatment for 6 months (Δ%FMD) were correlated with those of TBR in 33 drug-naive patients with essential hypertension. Multiple logistic regression analysis revealed that age (odds ratio, 1.767 for 10-year increase), male sex (odds ratio, 0.434), low-density lipoprotein-cholesterol (odds ratio, 1.630 for 26-mg/dL increase), and TBR values (odds ratio, 1.759 for 0.2 increase) were independently associated with %FMD in 145 patients. There was an inverse correlation between Δ%FMD and ΔTBR; ΔTBR was a sole independent associate of Δ%FMD in hypertensive patients ( r =−0.558; P <0.001). Conclusions— The present study showed that vascular inflammation in the carotid arteries evaluated by [ 18 F]-fluorodeoxyglucose-positron emission tomography/computed tomography was one of the independent correlates of decreased %FMD, thus suggesting the association of vascular inflammation with endothelial dysfunction in humans.

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Section: Methodological Considerationsmentioning

confidence: 99%

Section: Methodological Considerationsmentioning

confidence: 99%

Vascular Inflammation Evaluated by [ ¹⁸ F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction

Honda

Tahara

Nitta

et al. 2016

ATVB

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“…Moon et al [5] found a correlation of carotid FDG uptake and FRS, but not of carotid intima/media ratio, as a predictor of events during an average follow-up of 4.2 years. Similarly, Hetterich et al [6] found a correlation of FDG vascular uptake with traditional risk factors.…”

Section: Microcalcification (mentioning

confidence: 99%

From inflammation to calcification in atherosclerosis

Nakahara

Strausś

2017

Eur J Nucl Med Mol Imaging

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“…For example, MRI after the administration of recombinant HDL particles containing gadolinium 149 or ultra-small particles of iron oxide 150 can provide information about macrophage infiltration in plaque, or with microparticles of iron oxide targeting VCAM1 can provide information about endothelial activation -a critical step in atherosclerosis pathogenesis 103 . The use of 18 FDG-PET in combination with MRI can also improve characterization of plaque 'activity', with uptake indicating macrophage activity 151 ; high carotid FDG uptake is an independent predictor of cardiovascular events in asymptomatic patients 152 . The use of other tracers, such as 18 F-NaF, have also been used to identify microcalcification in the identification and localization of high-risk coronary plaques 153 .…”

Section: Molecular Techniques-mentioning

confidence: 99%

Erratum: Inflammatory processes in cardiovascular disease: a route to targeted therapies

Ruparelia¹,

Chai²,

Fisher³

et al. 2017

Nat Rev Cardiol

193

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Inflammatory processes are firmly established as central to the development and complications of cardiovascular diseases. Elevated levels of inflammatory markers have been shown to be predictive of future cardiovascular events. The specific targeting of these processes in experimental models has been shown to attenuate myocardial and arterial injury, reduce disease progression, and promote healing. However, the translation of these observations and the demonstration of clear efficacy in clinical practice have been disappointing. A major limitation might be that tools currently used to measure 'inflammation' are insufficiently precise and do not provide information about disease site, activity, or discriminate between functionally important activation pathways. The challenge, therefore, is to make measures of inflammation that are more meaningful, and which can guide specific targeted therapies. In this Review, we consider the roles of inflammatory processes in the related pathologies of atherosclerosis and acute myocardial infarction (AMI), by providing an evaluation of the known and emerging inflammatory pathways. We highlight contemporary techniques to characterize and quantify inflammation, and consider how they might be used to guide specific treatments. Finally, we discuss emerging opportunities in the field, including current limitations and challenges that are the focus of ongoing study.Inflammation and its failure to resolve are firmly established as central to the development and complications of several cardiovascular diseases [1][2][3] . Elevated levels of markers of inflammation, such as C-reactive protein (CRP) and serum amyloid A (SAA), have been shown to be predictive of future cardiovascular events across a range of clinical settings [4][5][6] . The role of the innate immune system in the pathogenesis of cardiovascular diseases has been an area of particular focus, with the appreciation that targeting innate immune function Correspondence to R.P.C.: robin.choudhury@cardiov.ox.ac.uk. Author contributionsAll the authors researched data for the article, discussed its contents, and wrote, reviewed, and edited the manuscript before submission. Competing interests statementThe authors declare no competing interests. HHS Public AccessAuthor manuscript Nat Rev Cardiol. Author manuscript; available in PMC 2017 September 01. Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript in experimental models can variously attenuate disease progression and injury, and promote healing [7][8][9][10] .Processes of inflammation contribute to a broad range of cardiovascular diseases; however, in this Review, we consider the roles of inflammatory processes in the related pathologies of atherosclerosis and acute myocardial infarction (AMI), by providing an evaluation of known and emerging inflammatory pathways that are thought to be central to their pathogenesis, and the consequences of their activation. We highlight contemporary techniques to characterize and quantify inflammation, and consider h...

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Carotid FDG Uptake Improves Prediction of Future Cardiovascular Events in Asymptomatic Individuals

Abstract: High carotid FDG uptake predicts cardiovascular events independent of traditional risk factors and CIMT in asymptomatic adults and may add to risk stratification beyond the FRS and CIMT.

Cited by 43 publications

References 32 publications

Vascular Inflammation Evaluated by [ ¹⁸ F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction

Vascular Inflammation Evaluated by [ ¹⁸ F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction

From inflammation to calcification in atherosclerosis

Erratum: Inflammatory processes in cardiovascular disease: a route to targeted therapies

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Carotid FDG Uptake Improves Prediction of Future Cardiovascular Events in Asymptomatic Individuals

Abstract: High carotid FDG uptake predicts cardiovascular events independent of traditional risk factors and CIMT in asymptomatic adults and may add to risk stratification beyond the FRS and CIMT.

Cited by 43 publications

References 32 publications

Vascular Inflammation Evaluated by [ 18 F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction

Vascular Inflammation Evaluated by [ 18 F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction

From inflammation to calcification in atherosclerosis

Erratum: Inflammatory processes in cardiovascular disease: a route to targeted therapies

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Resources

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Vascular Inflammation Evaluated by [ ¹⁸ F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction

Vascular Inflammation Evaluated by [ ¹⁸ F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction