Carotid endothelial shear stress reduction with aging is associated with plaque development in twelve years

Carallo, Claudio; Tripolino, Cesare; Franceschi, Maria Serena De; Irace, Concetta; Xu, Xiao Yun; Gnasso, Agostino

doi:10.1016/j.atherosclerosis.2016.05.048

Cited by 39 publications

(35 citation statements)

References 32 publications

(33 reference statements)

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“…Carallo et al [17] had demonstrated that the circumferential wall tension (WT) significantly increased with age [17]. Conversely, the present results showed the TS did not parallel the increase in CIMT and CCID.…”

Section: Discussioncontrasting

confidence: 74%

Evaluation of tensile stress in carotid artery: evidence from ultrasonography

Luo

et al. 2019

Preprint

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Section: Discussioncontrasting

confidence: 74%

Evaluation of tensile stress in carotid artery: evidence from ultrasonography

Luo

et al. 2019

Preprint

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“…The development of the atherosclerotic plaque is also influenced by the presence of mechanical forces that are exerted on the vessel wall (radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress). Mechanical forces regulate the cellular and molecular composition of plaques , as well as plaque growth . In particular, there is a reduction of endothelial shear stress with ageing, with subsequent development of atherosclerotic plaques .…”

Section: Shear Stress and Ageingmentioning

confidence: 99%

“…Mechanical forces regulate the cellular and molecular composition of plaques , as well as plaque growth . In particular, there is a reduction of endothelial shear stress with ageing, with subsequent development of atherosclerotic plaques .…”

Section: Shear Stress and Ageingmentioning

confidence: 99%

Arterial ageing: from endothelial dysfunction to vascular calcification

et al. 2017

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Complex structural and functional changes occur in the arterial system with advancing age. The aged artery is characterized by changes in microRNA expression patterns, autophagy, smooth muscle cell migration and proliferation, and arterial calcification with progressively increased mechanical vessel rigidity and stiffness. With age the vascular smooth muscle cells modify their phenotype from contractile to ‘synthetic’ determining the development of intimal thickening as early as the second decade of life as an adaptive response to forces acting on the arterial wall. The increased permeability observed in intimal thickening could represent the substrate on which low‐level atherosclerotic stimuli can promote the development of advanced atherosclerotic lesions. In elderly patients the atherosclerotic plaques tend to be larger with increased vascular stenosis. In these plaques there is a progressive accumulation of both lipids and collagen and a decrease of inflammation. Similarly the plaques from elderly patients show more calcification as compared with those from younger patients. The coronary artery calcium score is a well‐established marker of adverse cardiovascular outcomes. The presence of diffuse calcification in a severely stenotic segment probably induces changes in mechanical properties and shear stress of the arterial wall favouring the rupture of a vulnerable lesion in a less stenotic adjacent segment. Oxidative stress and inflammation appear to be the two primary pathological mechanisms of ageing‐related endothelial dysfunction even in the absence of clinical disease. Arterial ageing is no longer considered an inexorable process. Only a better understanding of the link between ageing and vascular dysfunction can lead to significant advances in both preventative and therapeutic treatments with the aim that in the future vascular ageing may be halted or even reversed.

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“…Wall shear stress (WSS), also called endothelial shear stress, is one of the most important hemodynamic forces that are exerted by circulating blood on the endothelial cell layer of the inner vessel wall [ 17 , 18 ]. It represents the tangential force per unit area exerted by flowing blood on the endothelial surface of the vascular wall and plays an important role in vascular remodeling and atherogenesis [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Carotid artery wall shear stress is independently correlated with renal function in the elderly

et al. 2018

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Hemodynamic has increasingly been regarded as an important factor of renal function. However, the relationship between carotid artery wall shear stress (WSS) and renal function is not clarified. To investigate the relationship between carotid WSS and renal function, we recruited 761 older subjects aged 60 years and over from community-dwelling in the Shandong area, China. Carotid WSS, endothelial function, and estimated glomerular filtration rate (eGFR) were assessed in all subjects. Subjects were grouped by the interquartile of the carotid artery mean WSS. We found that the eGFRs derived from serum creatinine and/or cystatin C using three CKD-EPI equations were significantly higher and albumin/creatinine ratio was lower in the higher interquartile groups than in the lower interquartile groups (P <0.05). The mean WSS was independently correlated with eGFRs even after adjustment for confounders. Similar findings were found between carotid artery peak WSS and eGFRs and albumin/creatinine ratio. In addition, we found that endothelial function was strongly related to carotid WSS and renal function after adjustment for confounders. In conclusion, there is an independent correlation of carotid WSS with renal function in the elderly. The local rheologic forces may play an important role in renal function changing. The correlation may be mediated by regulation of endothelial function.

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Carotid endothelial shear stress reduction with aging is associated with plaque development in twelve years

Cited by 39 publications

References 32 publications

Evaluation of tensile stress in carotid artery: evidence from ultrasonography

Evaluation of tensile stress in carotid artery: evidence from ultrasonography

Arterial ageing: from endothelial dysfunction to vascular calcification

Carotid artery wall shear stress is independently correlated with renal function in the elderly

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