Carotid Endarterectomy

Hara, Takayuki; Rai, Yurie

doi:10.1007/978-3-030-87649-4_10

Cited by 4 publications

(2 citation statements)

References 82 publications

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“…Statistically significative (p < 0.05) was the difference in the response rate of biomarkers between advanced CAAD and the other groups after the best medical therapy. These data are consistent with the literature, where the surgical treatment is indicated in advanced CAAD as the result of the reduced efficacy of medical therapy [25,26]. Different studies in the literature suggest that elevated blood pressure, smoking, cholesterol levels, increasing age, and male sex are associated with the presence of carotid artery stenosis.…”

Section: Discussionsupporting

confidence: 90%

Carotid Artery Disease in the Era of Biomarkers: A Pilot Study

et al. 2023

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The intima-media thickness (IMT) and its irregularities or ulcerations in the common carotid artery (CCA) are useful tools as sentinel biomarkers for the integrity of the cardiovascular system. Total homocysteine and lipoprotein levels are the most commonly used elements in cardiovascular risk stratification. Duplex ultrasound (DUS), associated with serum biomarkers, can be used simply to assess the degree of atherosclerotic disease and cardiovascular risk. This study highlights the role of different kinds of biomarkers, showing their usefulness and potentiality in multi-district atherosclerotic patients, especially for early diagnosis and therapy effectiveness monitoring. A retrospective analysis performed from September 2021 to August 2022, of patients with carotid artery disease, was performed. A total of 341 patients with a mean age of 53.8 years were included in the study. The outcomes showed an increased risk of stroke in patients with significative carotid artery disease, nonresponsive to therapy, monitored through a series of serum biomarkers (homocysteine, C-reactive protein, and oxidized LDL). In this reported experience, the systematic use of DUS in association with the multiple biomarkers approach was effective for the early identification of patients at higher risk of disease progression or inefficient therapy.

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Section: Discussionsupporting

confidence: 90%

Carotid Artery Disease in the Era of Biomarkers: A Pilot Study

et al. 2023

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“…With the acceleration of population aging and urbanization, along with the evident increase in stroke risk factors, the incidence of stroke overall is on the rise. One of the primary causes of ischemic stroke is carotid artery stenosis, with approximately 90% of cases attributed to atherosclerosis, leading to transient ischemic attacks (TIA) or stroke [ 1 , 2 ]. Surveys indicate that the prevalence rate of severe atherosclerotic carotid stenosis (stenosis degree ≥ 70%) in the general population is estimated to range from 0.1 to 3%, with higher rates observed in men, patients with coronary heart disease, and the elderly (aged ≥ 65 years) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative on the effectiveness and safety of different carotid endarterectomy techniques: a single-center Retrospective Study

Wu,

Wang,

Guo

et al. 2024

J Cardiothorac Surg

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Background Carotid endarterectomy (CEA) is a surgical procedure that can reduce the risk of stroke in patients with carotid artery stenosis. However, controversy still exists regarding the optimal surgical technique for CEA. Objective To compare the safety and effectiveness of different techniques. Methods Data on baseline characteristics as well as perioperative and postoperative complications from patients who underwent CEA at the Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, were retrospectively collected and analyzed. Results A total of 262 CEA patients included in study, with a total of 265 CEA operations. The mean age of 69.95 ± 7.29 (range, 44–89) years. 65 (24.5%) patients underwent cCEA, 94 (35.5%) underwent pCEA, and 106 (40.0%) underwent eCEA. The use of shunt (1.9%) and the mean operation time were lower in eCEA group (P < 0.05). eCEA was also associated with a lower incidence of postoperative hypotension, whereas pCEA was associated with a lower incidence of postoperative hypertension (P < 0.05). There was no significant difference in clinical baseline characteristics, occurrence of perioperative complications, and survival whether restenosis-free, asymptomatic or overall. Conclusions This study found that all three surgical methods are equally safe for the treatment of carotid artery stenosis and are effective in preventing stroke.

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