Carotid body tumors: a 16-year follow-up of 7 malignant cases

Martin, C E; Rosenfeld, L; McSwain, Barton

doi:10.1097/00006534-197405000-00082

Cited by 17 publications

(18 citation statements)

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“…The malignant potential of CBTs has been estimated between 5% and 10% [4][5][6][7][8]. Even without malignancy, CBTs can cause severe neurologic deficits and death [34][35]. Amongst others, this was the case in our patient who eventually died of an inoperable recurrent tumor.…”

Section: Discussionmentioning

confidence: 68%

Late outcome after surgical management of carotid body tumors from a 20-year single-center experience

Kotelis

Rizos

Geisbüsch

et al. 2008

Langenbecks Arch Surg

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Section: Discussionmentioning

confidence: 68%

Late outcome after surgical management of carotid body tumors from a 20-year single-center experience

Kotelis

Rizos

Geisbüsch

et al. 2008

Langenbecks Arch Surg

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“…These nonneuroendocrine sites most commonly include cervical lymph nodes or distant sites such as the lung, liver, and skin. 6 Overall, Ͻ 10% of all paragangliomas are malignant. 1,15 Previous findings have indicated that malignancy is least common (2-4%) for jugulo-tympanic tumors, approximately 6% for carotid body tumors, 1,11 and 16 -19% for vagal tumors.…”

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confidence: 99%

National Cancer Data Base report on malignant paragangliomas of the head and neck

Lee¹,

Barich²,

Karnell³

et al. 2002

Cancer

367

351

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BACKGROUNDMalignant paragangliomas of the head and neck are rare, with previous reports limited to nine or fewer patients. The current review included 59 cases extracted from the National Cancer Data Base that were diagnosed between 1985–1996.METHODS The primary criterion for inclusion in the current study was verified metastatic spread from a paraganglioma of the head and neck. Patterns of presentation and treatment as well as clinically relevant associations were demonstrated in contingency tables. Relative survival was used for analysis of outcome.RESULTSThe average patient age at presentation was 44 years, and gender distribution was equivalent. Metastases were confined to regional lymph nodes in the majority of cases (68.6%), with carotid body tumors found to have an even higher rate of regional confinement (93.8%). Surgery was the most common treatment (76.3%). The use of adjuvant irradiation for regionally confined disease increased across time, from 27% (1985–1990) to 46% (1991–1996). The 5‐year relative survival rate was 59.5% (76.8% for regionally confined carcinoma and 11.8% for distant metastasis). Among patients who were followed until death, those treated with adjuvant irradiation had a longer median survival (45 months) compared with those patients who were treated with surgery alone (12 months).CONCLUSIONS Malignant paraganglioma represents metastatic spread of a tumor type that, when restricted to the site of origin, is considered benign. Metastases from malignant paragangliomas of the head and neck usually are regionally confined. The primary management of a recognized malignancy should be directed toward complete surgical removal of the primary tumor and regional lymph nodes. Postoperative irradiation may be beneficial in slowing the progression of residual disease. Cancer 2002;94:730–7. © 2002 American Cancer Society.DOI 10.1002/cncr.10252

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“…'3823 A mortality rate of 8% in untreated cases has been reported. 24 Epidemiological studies suggest 2 forms of this disease: (1) a more common sporadic form, with a 5% incidence of bilateral t u m o r~,~~'~~ and (2) a familial form, which is rarer and is transmitted via an autosomal-dominant pattern.26 This is the form exemplified by our patients. It carries a 32% incidence of bilateral t~m o r s .~~,~~ Clinical presentation.…”

Section: Discussionmentioning

confidence: 67%