Carotid Body Paragangliomas and Matrix Metalloproteinases

Serra, Raffaele; Grande, Raffaele; Gallelli, Luca; Rende, Pierandrea; Scarcello, Edoardo; Buffone, Gianluca; Caliò, Francesco G.; Gasbarro, Vincenzo; Amato, Bruno; Franciscis, Stefano de

doi:10.1016/j.avsg.2014.03.022

Cited by 23 publications

(16 citation statements)

References 22 publications

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“…The ELISA test was performed as previously reported . A commercially available sandwich ELISA kit with MMP‐1, ‐2, ‐3 and ‐9 monoclonal antibodies (Biotrak Human ELISA System, Amersham Pharmacia Biotech, Buckinghamshire, UK) was used to determine plasma MMP levels.…”

Section: Methodsmentioning

confidence: 99%

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Biomarkers in post‐reperfusion syndrome after acute lower limb ischaemia

Franciscis

Caridi

Massara

et al. 2014

International Wound Journal

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Ischaemia reperfusion (I/R) injury refers to tissue damage caused when blood supply returns to the tissue after a period of ischaemia. Matrix metalloproteinases (MMPs), neutrophil gelatinase-associated lipocalin (NGAL) and cytokines are biomarkers involved in several vascular complications. The aim of this study was to evaluate the role of MMPs, NGAL and inflammatory cytokines in I/R syndrome. We conducted an open label, multicentric, parallel group study, between January 2010 and December 2013. Patients with acute limb ischaemia were enrolled in this study and were divided into two groups: (i) those subjected to fasciotomy and (ii) those not subjected to fasciotomy, according to the onset of compartment syndrome. Plasma and tissue values of MMPs and NGAL as well as plasma cytokines were evaluated. MMPs, NGAL and cytokine levels were higher in patients with compartment syndrome. Biomarkers evaluated in this study may be used in the future as predictors of I/R injury severity and its possible evolution towards post-reperfusion syndrome.

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Section: Methodsmentioning

confidence: 99%

“…MMPs are proteolytic enzymes that degrade the extracellular matrix (ECM) and play a role in both vascular and non‐vascular diseases. Furthermore, it has been documented that MMPs are significantly involved in I/R injury in the lung, heart, brain and kidney .…”

Section: Introductionmentioning

confidence: 99%

Biomarkers in post‐reperfusion syndrome after acute lower limb ischaemia

Franciscis

Caridi

Massara

et al. 2014

International Wound Journal

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“…Some studies revealed that matrix metalloproteinase (MMP) enzymes are elevated in patients with CBTs compared to healthy patients. 10 MMPs that regulate cell matrix composition play a role in several conditions, including embryogenesis, wound healing, inflammation, and cancer. MMPs seem to be more elevated on malignant CBTs, but this relation is not clear.…”

Section: Discussionmentioning

confidence: 99%

Submandibular approach and use of Ligasure^® system in a complex carotid paraganglioma

Esquivel

Kiuri

Heredero

et al. 2014

SAGE Open Medical Case Reports

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Carotid paragangliomas are rare tumors of slow growth, progressive, and highly vascularized; surgery is the chosen treatment, and most surgeons perform an approach with a longitudinal cervicotomy.Objective:We present a case of carotid paraganglioma Shamblin III with skull base extension.Methods:Submandibular approach and vascular sealing device of the Ligasure® system were used in the surgery.Results:We achieved complete resection using these adjunctive techniques.Conclusions:The use of these adjunctive techniques can be useful to manage large carotid body tumors.

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“…The aetiology is multifactorial : venous hypertension and stasis play an important role in the genesis of venous ulcers, but microcirculatory alterations and inflammation are also involved. Several studies have shown that matrix metalloproteinases (MMPs) are the main biological effectors of the inflammatory process, which characterises the pathophysiology of vascular and non‐vascular disease . Contemporary signs of peripheral arterial disease with a reduced ankle‐brachial pressure index (ABPI <0·8) are present in around 15–30% of patients with CVU .…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of prostaglandin E1 in patients with mixed arterial and venous ulcers of the lower limbs

Caridi

Massara

Stilo

et al. 2014

International Wound Journal

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Mixed arterial and venous ulcers of the lower limbs are present in around 15-30% of patients with chronic venous ulcers (CVUs) and are considered difficult-to-heal wounds. The aim of this study was to evaluate the results of the treatment of mixed arterial and venous ulcers of the lower limbs with prostaglandin E1 (PGE1) infusion. This study was carried out in 48 consecutive patients. Patients who showed intolerability to PGE1, and patients with peripheral neuropathy, blood or systemic diseases, malignancy and acute wound infections or necrotic tissue on the wound bed were excluded. The patients were separated at random into two main groups: group I (25 patients) received standard treatment and PGE1 infusion. Group II (23 patients) received only standard treatment. Pre-treatment data indicated the area of ulceration. The number of healed ulcers and the variation in the area of ulceration were considered as endpoints. The endpoints were noticed after 120 days from the beginning of treatment. Healing occurred in 80% of limbs of group I and in 52·2% of limbs of group II patients. The average reduction in area was 92% versus 60% in patients of group I and II, respectively. During the whole treatment period, the incidence of adverse events was 8% in group I: there was one case of headache and one case of headache and hypotension combined. No side effects were recorded in patients of group II. In conclusion, PGE1 infusion is a determinant in the reduction of the healing time of mixed ulcers of the lower limbs.

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Carotid Body Paragangliomas and Matrix Metalloproteinases

Cited by 23 publications

References 22 publications

Biomarkers in post‐reperfusion syndrome after acute lower limb ischaemia

Biomarkers in post‐reperfusion syndrome after acute lower limb ischaemia

Submandibular approach and use of Ligasure^® system in a complex carotid paraganglioma

Effectiveness of prostaglandin E1 in patients with mixed arterial and venous ulcers of the lower limbs

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Carotid Body Paragangliomas and Matrix Metalloproteinases

Cited by 23 publications

References 22 publications

Biomarkers in post‐reperfusion syndrome after acute lower limb ischaemia

Biomarkers in post‐reperfusion syndrome after acute lower limb ischaemia

Submandibular approach and use of Ligasure® system in a complex carotid paraganglioma

Effectiveness of prostaglandin E1 in patients with mixed arterial and venous ulcers of the lower limbs

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Product

Resources

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Submandibular approach and use of Ligasure^® system in a complex carotid paraganglioma