Carotid artery intima-media thickness correlates with intravascular ultrasound parameters in patients with slow coronary flow

Çamsarı, Ahmet; Özcan, Türkay; Özer, Caner; Akçay, Burak

doi:10.1016/j.atherosclerosis.2007.12.028

Cited by 37 publications

(38 citation statements)

References 34 publications

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“…On the other hand, Mosseri et al (1986) suggested that occlusive disease of small coronary arteries might be etiology of SCF phenomenon. Many intravascular ultrasound studies suggested the evidence of diffuse atherosclerosis in SCF phenomenon (Cin et al 2003;Pekdemir et al 2004;Camsari et al 2008). Erdogan et al (2007) suggested that the coronary flow reserve (CFR) is impaired in patients with SCF.…”

Section: Discussionmentioning

confidence: 99%

Impaired Cerebral Circulation in Patients with Slow Coronary Flow

Karakaya

Koçer

Esen

et al. 2011

Tohoku J. Exp. Med.

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Slow coronary flow (SCF) is characterized by delayed opacification of coronary arteries during coronary angiography and is associated with myocardial perfusion abnormalities, ischemia or myocardial infarction. We hypothesized that SCF could be a part of systemic circulatory abnormalities. Therefore, the present study was conducted to investigate whether cerebral blood flow velocity is altered in patients with SCF. The study included 16 patients suffering from chest pain with angiographically proven SCF and 16 subjects suffering from atypical chest pain with angiographically normal coronary flow. All study subjects were selected among those who undergone routine cardiac catheterization. SCF was defined based on thrombolysis in myocardial infarction frame count that reflects coronary artery flow. Thrombolysis in myocardial infarction frame count was significantly higher in patients with SCF than those with normal coronary flow. The average peak systolic, end diastolic and mean flow velocities of the middle cerebral artery were measured and recorded in both groups by transcranial Doppler ultrasonography. Baseline demographic properties were similar in both groups. Echocardiographic parameters were also similar in patients with SCF and those with normal coronary flow. In contrast, both right and left middle cerebral artery peak systolic, end diastolic and mean flow velocities were significantly lower in patients with SCF than those with normal coronary flow. We conclude that cerebral blood flow velocity is significantly lower in patients with SCF. SCF phenomenon may reflect a part of impaired systemic circulation.Keywords: cerebral blood flow; coronary angiography; slow coronary flow; thrombolysis in myocardial infarction frame count; transcranial Doppler Tohoku J. Exp. Med., 2011, 225 (1), 13-16. © 2011 Tohoku University Medical Press Slow coronary flow (SCF), characterized by slow antegrade progression of dye in the absence of obstructive coronary disease, has been noted in the coronary arteries during routine angiographic study, but its precise mechanism has not been well documented. SCF was first defined by Tambe at al. (1972) on six patients with chest pain. However, the exact etiology, pathogenesis and long term outcome of SCF patients is still unknown although endothelial, vasomotor and microvascular dysfunction and occlusive disease of small coronary arteries were suggested in its etiology (Moserri et al. 1986;Mangieri et al. 1996;Sezgin et al. 2003). It is also unknown whether SCF phenomenon is a disorder limited to the coronary artery or it involves cerebral circulation as well.Transcranial Doppler ultrasonography (TCD) is a noninvasive method that provides reliable information about the hemodynamic status of the cerebral circulation. TCD is relatively cheap, can be performed bedside, and allows monitoring both in acute emergency settings as well as for prolonged periods with a high temporal resolution making it ideal for studying dynamic cerebrovascular responses. Also, systolic upstroke, velocity, pulsat...

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Section: Discussionmentioning

confidence: 99%

Impaired Cerebral Circulation in Patients with Slow Coronary Flow

Karakaya

Koçer

Esen

et al. 2011

Tohoku J. Exp. Med.

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“…Nevertheless, the histopathological characteristics are similar to coronary atherosclerosis and microvascular dysfunction and free radical damage may be responsible for the pathology (1,7,23). Previous studies reported significantly increased intima-media thickness (IMT) of the carotid artery which is known as a marker of subclinical atherosclerosis in patients with SCF (24,25).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that resting microvascular resistance and flow-mediated dilatation are deteriorated in SCF patients (4)(5)(6). Potential causes of SCF are small vessel disease, diffuse atherosclerosis, platelet dysfunction, microvascular dysfunction and vasomotor dysfunction (1,7). Reactive oxygen species (ROS) and oxidative stress may contribute to the pathophysiology of atherosclerotic diseases (8).…”

Section: Introductionmentioning

confidence: 99%

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Ischemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational study

Koç

Erdem²,

Altunkaş³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Yavaş koroner akım (YKA) önemli darlık olmaksızın epikardiyal koroner arterlerin geç opasifiye olmasıdır. Yavaş koroner akım oluşumundaki temel mekanizma koroner ateroskleroza benzer ve serbest radikal oluşumu patolojiden sorumlu olabilir. Biz bu çalışmada, normal koroner arterli hastalarla, daralma olmaksızın YKA bulunan hastalar arasında iskemi-modifiye albümin (İMA) seviyeleri ve total antioksidan durum (TAD) açısından farklılık olup olmadığını araştırdık. Yöntemler: Koroner anjiyografi sırasında YKA bulunan 30 ardışık hasta (13 erkek; ortalama yaş 56±10 yıl) ile normal koroner artere sahip olup YKA olmayan 30 kişi (13 erkek; ortalama yaş 53±11 yıl) kontrol grubu olarak bu gözlemsel enine-kesitli çalışmaya alındı. Bu çalışmada serum İMA seviyeleri, albümine göre düzeltilmiş İMA ve TAD ölçüldü. İki grup arasında serum İMA seviyeleri ve TAD'ı değerlendirmek için Student t-testi kullanıldı. Serum İMA seviyeleri ve TAD arasındaki ilişkiyi açıklamak için Pearson korelasyon testi uygulandı. Bulgular: Serum İMA seviyeleri ve albümine göre düzeltilmiş İMA her iki grupta benzerdi (p=0.432, p=0.349). Ortalama TAD değeri YKA grubunda kontrol grubuna göre daha düşük bulundu (p=0.011). Yavaş koroner akım hastalarında TAD ile serum İMA seviyeleri ve albümine göre düzeltilmiş İMA arasında negatif ilişki tespit edildi (r=-0.457, p=0.011; r=-0.509, p=0.004). Sonuç: Bu çalışma göstermiştir ki, serum İMA seviyeleri ve albümine göre düzeltilmiş İMA gruplar arasında benzerken, ortalama TAD değeri YKA grubunda kontrol grubundan daha düşük ve İMA ile negatif olarak ilişkilidir. Bu sonuçlar YKA patofizyolojisini anlamak için önemli bulunmuştur. (Anadolu Kardiyol Derg 2011; 11: 582-7) Anahtar kelimeler: Antioksidan durum, iskemi-modifiye albümin, yavaş koroner akım ABSTRACT Objective: Slow coronary flow (SCF) is defined as late opacification in the epicardial coronary arteries without significant stenosis. The underlying mechanism of SCF is similar to coronary atherosclerosis. Free radical damage may be responsible for the pathology. In this study, we aimed to investigate ischemia-modified albumin (IMA) levels and differences with regard to total antioxidant status (TAS) between patients with normal coronary arteries and patients with SCF without significant stenosis. Methods: Thirty patients who were diagnosed with SCF using coronary angiography were included in this cross-sectional observational study (13 male; mean age, 56±10 years). The control group consisted of 30 patients who had normal coronary arteries as shown by coronary angiography (13 male; mean age, 53±11 years). In this study, we assessed serum IMA levels, albumin-adjusted IMA and TAS. The Student t-test was used to compare serum IMA levels and TAS between the two groups. Pearson's correlation test was used to explore the relationship between TAS and serum IMA levels. Results: Serum IMA levels and albumin-adjusted IMA were similar in both groups (p=0.432, p=0.349). The mean value of TAS was significantly lower in the SCF group compared to control group (p=0.0...

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“…Some studies have implicated that SCF may be manifestation of diffuse atherosclerotic disease [21,22]. In recent years, it has been recognized that atherogenesis is an active, chronic inflammatory process [10,11,23,24].…”

Section: Discussionmentioning

confidence: 99%

The evaluation of relationship between neutrophil-to-lymphocyte ratio and slow

Ertürk¹

2013

DicleMedj

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Objective: The aim of this study was to investigate the correlations between leukocyte counts, the neutrophil-tolymphocyte ratio (NLR), and slow coronary flow (SCF). Methods:We evaluated 135 patients undergoing coronary angiography (CAG) within coronary artery disease (CAD) indication. We divided patients into three groups according to the CAG findings. Group 1 consisted of 45 patients with an SCF pattern; group 2 consisted of 45 patients with at least 50% lumen narrowing in at least one epicardial coronary artery; and group 3 (control group) consisted of 45 patients with normal coronary arteries. The quantification of the coronary flow was assessed using the thrombolysis in myocardial infarction (TIMI) frame count method for each of the coronary arteries. Blood samples were collected from the patients after a 12 h overnight fasting. The NLR ratio was calculated from the automated complete blood count.Results: NLR in CAD was higher than in both the SCF and control groups (p=0.008, p<0.001, respectively). However, there was no statistically significant difference between SCF and control group (p=0.768). Neutrophil counts in CAD were higher than in both SCF and control groups, but only the difference between CAD and SCF groups was statistically significant (p=0.010). Conclusion:Our study revealed that circulating neutrophil counts and NLR were related to the coronary artery disease, as expected.Key words: Neutrophil-to-lymphocyte ratio, leukocyte subtype, slow coronary flow, coronary artery disease ÖZET Amaç: Çalışmamızda yavaş koroner akım (SCF) ile nöt-rofil/lenfosit oranı (NLR) ve lökosit alt tipleri arasındaki ilişkiyi araştırmayı amaçladık.Yöntemler: Çalışmaya; koroner arter hastalığı şüphesiy-le koroner anjiyografisi yapılan toplam 135 hasta alındı. Hastalar koroner anjiyografisi sonucuna göre üç gruba ayrıldı: yavaş koroner akım saptanan 45 hasta grup 1, en az bir koroner arterinde 50% ve üzerinde darlık saptanan 45 hasta grup 2 ve normal koroner arterlere sahip 45 kişi ise grup 3'e (kontrol grubu) dahil edildi. Koroner yavaş akım tanısı her bir koroner arterin TIMI kare sayısı hesaplanarak kondu. Tüm hastalardan 12 saatlik açlık sonrası kan örnekleri alındı. NLR oranı tam kan sayımından faydalanılarak hesaplandı.Bulgular: Nötrofil/lenfosit oranı koroner arter hastalığına sahip olanlarda, yavaş koroner akım ve kontrol grubuna göre anlamlı olarak daha yüksekti (sırasıyla p=0,008 ve p<0,001). Fakat NLR oranı yavaş koroner akım ve kontrol grubunda benzer bulundu (p=0.768). Nötrofil sayıları koroner arter hastalığı grubunda SCF ve kontrol grubuna göre daha yüksekti, ancak sadece koroner arter hastalığı ve yavaş koroner akım grubu arasındaki fark istatistiksel olarak anlamlıydı (p=0,010). Sonuç: Çalışmamızda

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Carotid artery intima-media thickness correlates with intravascular ultrasound parameters in patients with slow coronary flow

Cited by 37 publications

References 34 publications

Impaired Cerebral Circulation in Patients with Slow Coronary Flow

Impaired Cerebral Circulation in Patients with Slow Coronary Flow

Ischemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational study

The evaluation of relationship between neutrophil-to-lymphocyte ratio and slow

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