Carotid artery elongation (carotid dolichoarteriopathy): some features of the structure and hemodynamics

Abstract

The purpose of the study. Multimodal study of the state of the brachiocephalic arteries, with assessment of blood flow in the extra- and intracranial portions of the carotid arteries and brain perfusion, as well as the structure of the brain in patients with different types of elongation of the carotid arteries (ECA).Material and methods. The data of examinations of 79 patients (45 men (57.0%, average age – 61.0 ± 10.1 years) and 34 women (43.0%, 65.3 ± 13.6 years), average age 62.8 ± 11.8 years) during the year after ischemic stroke in posterior circulation were analyzed. ECA was verified by multispiral computed tomographic angiography (msCTA) in 44 patients (55.7% of the total number of cases), the control group was selected by gender and age with “case-control” elements and consisted of 35 (44.3%) patients without a mustache. All underwent msCTA of the thoracic aorta and BCA and CT perfusion examination, magnetic resonance imaging of the brain, duplex scanning of BCA and transcranial duplex scanning, transthoracic echocardiography, transcranial Doppler monitoring with microembolodetection.Results. We have registered intergroup differences, which can be divided into structural and functional. The former include: higher aortic arch location in patients with DCA: ThII – 6.3% vs. 0%, ThIII – 43% vs. 0%; ThIV – 28.1% vs. 62.9%* and ThV 21.9% vs. 37.1% (p < 0.0005); lower values of cervical spine height (114.70 ± 11.03 mm, vs. 120.46 ± 9.75 mm, p = 0.022), greater absolute length of the ICA (on the right – 101.32 ± 14.59 mm vs. 85.06 ± 12.07 mm, p < 0.0005; on the left – 100.00 ± 14.03 mm vs. 84.66 ± 12.63 mm, p < 0.0005). The presence of ECA was associated (p < 0.05) with a higher frequency of vertebral artery elongation. The severity of small vessel disease during MRI in individuals with ECA was slightly higher (not at the trend level, p = 0.076). Functional differences consisted in the registration of lower (p = 0.019) values of the end diastolic velocity in M1 of the middle cerebral arteries. The values of some perfusion indices in the blood supply of elongation arteries were lower than in persons without ECA. There were no cases of registration of microembolic signals in the ECA patients examined by us.Conclusion. In the individuals with ECA we examined, a complex of anatomical and hemodynamic features was determined, which, both individually and collectively, cannot lead to a decrease in the level of blood flow or be a source of arterio-arterial embolism in the carotid system, regardless of the configuration of the ICA.