Carotid artery Doppler ultrasonography in patients with chronic kidney disease

Abstract

BackgroundWe investigated the changes in the values of carotid intima-media thickness (IMT) and Doppler index measurements in the autosomal dominant polycystic kidney disease (ADPKD), peritoneal dialysis (PD), and hemodialysis (HD) patients.Material/MethodsTwenty outpatients on HD (mean age 46.1±16.4), 27 outpatients on PD (mean age 45±12.4), and 26 normotensive outpatients with ADPKD (mean age 52.4±16.7) as the case groups and 21 healthy subjects (mean age 48.4±7.2), as the control group, were included. The participants underwent ultrasonography of the common, right, and left carotid arteries for the IMT and Doppler flow measurements.ResultsOverall, compared to the normal group, in the study groups, the IMT and peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index (RI), and pulsatility index (PI) were significantly higher in common carotid arteries; however, their differences were not meaningful in internal carotid arteries (p<0.05).ConclusionsOverall, ADPKD, PD, and HD increase the IMT, PSV, EDV, RI, and PI values of CCA; however, their effect considerable less on the study parameters of ICA. There is no considerable difference among the effects of ADPKD, HD, and PD on the study parameters. Of CKD patients during the first diagnostic and follow-up workups, the measurements of carotid IMT and Doppler indices may provide valuable data for improving success of the clinical management.

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease

“…These results support existing literature that has demonstrated higher cIMT values in patients with CKD [34, 35], or end-stage renal disease [36]. Children with CKD on dialysis or following renal transplant have also demonstrated increased cIMT and fIMT values compared to healthy children [10-12, 37-39]. On the contrary, a few published studies failed to demonstrate any difference in cIMT values between CKD patients and controls, which is presumably attributable to less severe forms of atherosclerosis in their CKD populations [40].…”

Appraisal of different ultrasonography indices in patients with carotid artery atherosclerosis

“…Common carotid intima-media thickness (IMT) assessed by B-mode ultrasound has been shown to have great reproducibility and can provide a reliable index for carotid atherosclerosis (Stein et al, 2008[ 37 ]). Besides, Doppler modality provided an appropriate tool to evaluate vascular flow velocity and systemic CVD in order to diagnosis and management of atherosclerotic conditions (Salk et al, 2014[ 35 ]).…”

Observational multicenter study to evaluate the prevalence and prognosis of subclinical atheromatosis in a Spanish chronic kidney disease cohort: baseline data from the NEFRONA study

“…The application of diagnostic tests in CKD (i.e. vascular ultrasound or ankle-brachial index) to detect subclinical atheromatosis and adequately stratify cardiovascular risk has not yet been specifically addressed, although there are some initial promising data [ 16 , 17 ].…”