Carotid artery and jugular vein ligation with and without hypoxia

Klein, Michael D.; Lessin, Marc S.; Whittlesey, Grant C.; Chang, Chung Ho; Becker, Cristie J.; Meyer, Sabrina; Smith, Alexander M.

doi:10.1016/s0022-3468(97)90708-9

Cited by 6 publications

(5 citation statements)

References 51 publications

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“…Klein and associates also evaluated the effect of vessel ligation on the brain. 26 MRI studies immediately post study in this same model did not reveal any difference in the ligated and nonligated animals. Although the results of this study are reassuring, it does not address the events which may occur if other pathophysiologic events are superimposed during this period, such as systemic hypotension or hypertension.…”

Section: Ecmo Risk Factorsmentioning

confidence: 61%

The effect of extracorporeal life support on the brain: A focus on ECMO

Short

2005

Seminars in Perinatology

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Section: Ecmo Risk Factorsmentioning

confidence: 61%

The effect of extracorporeal life support on the brain: A focus on ECMO

Short

2005

Seminars in Perinatology

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“…Furthermore, these mice were exposed to 35°C for 4 h following ligation. In adult rats, CAϩJV ligation combined with or without preceding hypoxia was shown to cause sporadic and occasional brain damage (18). In CAϩJV-ligated mice subjected to normothermia at p9 -11, no cerebral damage was detected.…”

Section: Discussionmentioning

confidence: 97%

“…As the main goal of this study was to determine whether an isolated ligation of CAϩJV followed by hyperthermia induces cerebral ischemia, mice were not subjected to hypoxia, which other investigators have used to model preECMO hypoxemia in rodents (18).…”

Section: Methodsmentioning

confidence: 99%

Systemic Hyperthermia Induces Ischemic Brain Injury in Neonatal Mice With Ligated Carotid Artery and Jugular Vein

et al. 2007

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Postnatal d 7 (p7) or p12 mice had their right carotid artery (CA) and jugular vein (JV) ligated to mimic veno-arterial (VA) access for extracorporeal membrane oxygenation (ECMO). At p9 -11 (early) or p19 -21 (late) mice were exposed to hyperthermia or normothermia followed by assessment of neuropathological injury score. In separate cohorts of mice, cerebral and peripheral blood flow (CBF, PBF) and cerebral ATP content was measured. Hyperthermia resulted in ischemic brain injury in 57% and 77% of mice subjected to early or late hyperthermia, respectively. Isolated CAϩJV ligation induced minimal injury (score 0.47 Ϯ 0.34) in 2/8 mice from the late normothermia group. No cerebral injury was detected in mice subjected to early normothermia. In 3/19 shams (2/10 early, 1/9 late) hyperthermia induced a subtle (score, 0.6 Ϯ 0.27) injury in the ipsilateral to the site of surgery cortex. CBF and PBF increased in response to hyperthermia in all mice. The rise in CBF was significantly attenuated in the "ligated" versus intact hemisphere, which was associated with a profound depletion of ATP content. Systemic hyperthermia induces ischemic brain injury in mice with ligated CAϩJV. We speculate that hyperthermia/fever can be a potential risk factor for brain injury in infants treated with VA ECMO.

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“…These parameters were not altered by cannulation of the right common carotid artery and/or the right internal jugular vein. A second study by Klein et al [59] found no statistically significant or persistent differences on MRI performed directly after ligation between rats in which either the jugular vein and/or the carotid artery were ligated compared to control rats. Less reassuring studies, considering the cannulation procedure, occurred as well.…”

Section: Cerebral Aspects Related To Neonatal Ecmomentioning

confidence: 99%

Cerebral Aspects of Neonatal Extracorporeal Membrane Oxygenation: A Review

2013

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Background: Neonatal extracorporeal membrane oxygenation (ECMO) is a lifesaving therapeutic approach in newborns suffering from severe, but potentially reversible, respiratory insufficiency, mostly complicated by neonatal persistent pulmonary hypertension. However, cerebral damage, intracerebral hemorrhage as well as ischemia belong to the most devastating complications of ECMO. Objectives: The objectives are to give insights into what is known from the literature concerning cerebral damage related to neonatal ECMO treatment for pulmonary reasons. Methods: A short introduction to ECMO indications and technical aspects of ECMO are provided for a better understanding of the process. The remainder of this review focuses on outcome and especially on (potential) risk factors for cerebral hemorrhage and ischemia during ECMO treatment. Results: Although neonatal ECMO treatment shows improved outcome compared to conservative treatment in cases of severe respiratory insufficiency, it is related to disturbances in various aspects of neurodevelopmental outcome. Risk factors for cerebral damage are either related to the patient's disease, EMCO treatment itself, or a combination of both. Conclusion: It is of ongoing importance to further understand pathophysiological mechanisms resulting in cerebral hemorrhage and ischemia due to ECMO and to develop neuroprotective strategies and approaches.

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Carotid artery and jugular vein ligation with and without hypoxia

Cited by 6 publications

References 51 publications

The effect of extracorporeal life support on the brain: A focus on ECMO

The effect of extracorporeal life support on the brain: A focus on ECMO

Systemic Hyperthermia Induces Ischemic Brain Injury in Neonatal Mice With Ligated Carotid Artery and Jugular Vein

Cerebral Aspects of Neonatal Extracorporeal Membrane Oxygenation: A Review

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