Carotid and femoral artery stiffnessin Takayasu's arteritis

Raninen, Reino O; Kupari, Markku; Hekali, P

doi:10.1080/03009740252937595

Cited by 38 publications

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“…Mean IMT of carotid arteries was also increased significantly compared with controls. Arterial stiffness is also more prominent in carotid arteries and aorta, areas affected predominantly by Takayasu arteritis, rather than the peripheral femoral arteries which are affected only infrequently by the disease [33].…”

Section: Occurrence Of Accelerated Atherosclerosis In Vasculitismentioning

confidence: 93%

Translational Mini-Review Series on Immunology of Vascular Disease: Accelerated atherosclerosis in vasculitis

Tervaert

2009

Clinical and Experimental Immunology

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SummaryPremature atherosclerosis has been observed during the course of different systemic inflammatory diseases such as rheumatoid arthritis and sytemic lupus erythematosus. Remarkably, relatively few studies have been published on the occurrence of accelerated atherosclerosis in patients with vasculitis. In giant cell arteritis (GCA), mortality because of ischaemic heart disease is not increased. In addition, intima media thickness (IMT) is lower in patients with GCA than in age-matched controls. In contrast, IMT is increased significantly in Takayasu arteritis, another form of large vessel vasculitis occurring in younger patients. In Takayasu arteritis and in Kawasaki disease, a form of medium-sized vessel vasculitis, accelerated atherosclerosis has been well documented. In small vessel vasculitis because of anti-neutrophil cytoplasmic autoantibodies-associated vasculitis, cardiovascular diseases are a major cause of mortality. IMT measurements reveal conflicting results. During active disease these patients experience acceleration of the atherosclerotic process. However, when inflammation is controlled, these patients have atherosclerotic development as in healthy subjects. Several risk factors, such as diabetes and hypertension, are present more often in patients with vasculitis compared with healthy controls. In addition, steroids may be pro-atherogenic. Most importantly, many patients have impaired renal function, persistent proteinuria and increased levels of C-reactive protein, well-known risk factors for acceleration of atherosclerosis. Enhanced oxidation processes, persistently activated T cells and reduced numbers of regulatory T cells are among the many pathophysiological factors that play a role during acceleration of atherogenesis. Finally, autoantibodies that may be relevant for acceleration of atherosclerosis are found frequently in elevated titres in patients with vasculitis. Because patients have an increased risk for cardiovascular events, vasculitis should be treated with as much care as possible. In addition, treatment should be considered with angiotensin-converting-enzyme inhibitors and/or angiotensin receptor-1 blockers, statins and acetylsalicyl acid. Finally, classical risk factors for cardiovascular disease should be monitored and treated as much as possible.

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Section: Occurrence Of Accelerated Atherosclerosis In Vasculitismentioning

confidence: 93%

Translational Mini-Review Series on Immunology of Vascular Disease: Accelerated atherosclerosis in vasculitis

Tervaert

2009

Clinical and Experimental Immunology

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“…Decreased arterial distensibility and increased SI were shown to be accompanied by increased wall thickness [14], so the visualization of segments with thickened arterial walls can guide to ''hot spots'', where functional arterial assessment by elasticity measurements should be performed during follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Within the last few years, MRI, MR-angiography, 2-dimensional and colour duplex ultrasound, CT and 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG-PET) proved to be potentially useful for evaluation of TA [3,8,11,14,17,22]. MR-and CT-angiography provide a generalised arterial survey of affected vessels.…”

Section: Discussionmentioning

confidence: 99%

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Reduced aortic elastic properties in a child with Takayasu arteritis: case report and literature review

Baumgartner

Sailer‐Höck

Baumgartner³

et al. 2005

Eur J Pediatr

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“…Dzięki rozdzielczości 0,1-0,2 mm umożliwia badanie małych tętnic [12]. Może być używane do bezpośrednie-go pomiaru sztywności naczynia, która zwiększa się w TA [30,31]. Ma jednak także wady.…”

Section: Badania Obrazoweunclassified

Takayasu arteritis: is disease activity assessment possible?

Rowińska-Osuch¹,

Więsik-Szewczyk²,

Olesińska³

2013

Reumatologia

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P Pr ra ac ca a w wp pł ły yn nę ęł ła a: : 22.05.2012 r. S t r e s z c z e n i eChoroba Takayasu (TA) jest rzadkim zapaleniem dużych tętnic. Początek choroby jest podstępny, może pozostać niezauważony. Przewlekłe zapalenie prowadzi do nieodwracalnych konsekwencji: powikłań sercowo-naczyniowych, niedrożności naczyń, zaniewidzenia czy przełomu nadciśnieniowego. Z uwagi na układowy charakter schorzenia pacjenci trafiają do specjalistów różnych dziedzin: reumatologów, okulistów, kardiologów i chirurgów naczyniowych. Dostępne metody farmakoterapii wpływają tylko na aktywne zmiany zapalne. Przedłużające się leczenie glikokortykosteroidami ma niekorzystne skutki odległe i nie powinno być nadużywane. Aby określić efekt leczenia, wybrać moment jego modyfikacji, konieczna jest ocena aktywności choroby. Celem prezentowanej pracy jest przedstawienie możliwości oceny aktywności TA. W diagnostyce znaczącą rolę odgrywają badania obrazowe naczyń: ultrasonografia i rezonans magnetyczny. Prowadzone są prace dotyczące pozytonowej tomografii emisyjnej (positron emission tomography -PET), która jest badaniem czułym, ale trudno dostępnym, kosztownym i wymagającym walidacji. Poszukuje się również biomarkera, którego wartości korelowałyby z aktywnością choroby. Wśród potencjalnych kandydatów na biomarker są interleukiny 6, 12, 18. Aktualnie opracowywane są skale aktywności choroby, np. DEI.Tak (Disease Extent Index-Takayasu). Żadne z tych narzędzi nie jest uniwersalne.

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Carotid and femoral artery stiffnessin Takayasu's arteritis

Abstract: Carotid artery compliance is strongly diminished in patients with TA. A comparable but somewhat less conspicuous change is seen in the femoral arteries.

Cited by 38 publications

References 0 publications

Translational Mini-Review Series on Immunology of Vascular Disease: Accelerated atherosclerosis in vasculitis

Translational Mini-Review Series on Immunology of Vascular Disease: Accelerated atherosclerosis in vasculitis

Reduced aortic elastic properties in a child with Takayasu arteritis: case report and literature review

Takayasu arteritis: is disease activity assessment possible?

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