Carotenoids and Their Health Benefits as Derived via Their Interactions with Gut Microbiota

Eroglu, Abdulkerim; Al'Abri, Ibrahim S; Kopec, Rachel; Crook, Nathan; Bohn, Torsten

doi:10.1016/j.advnut.2022.10.007

Cited by 33 publications

(17 citation statements)

References 190 publications

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“…The microbial origin of these compounds has been demonstrated in previous mouse experiments, as evidenced by cinnamoylglycine 46 . The positive mediation observed between dietary beta-cryptoxanthin, a carotenoid primarily found in fruits and vegetables, and CAG01699: Marvinbryantia formatexigens DSM 14469 (Figure 6D) can be interpreted as the positive influence of nutritional compounds on gut microbiome species, as it has also demonstrated dose-dependent probiotic effects 47 .…”

Section: Resultsmentioning

confidence: 99%

The Gut Microbiome Strongly Mediates the impact of Lifestyle combined variables on Cardiometabolic Phenotypes

Adriouch,

Belda,

Swartz

et al. 2024

Preprint

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Individual lifestyle factors moderately impact the gut microbiome and host biology. This study explores whether their combined influence significantly alters the gut microbiome and determines the mediating role of the gut microbiota in the relationship between lifestyle and phenomes. Analyzing 1,643 individuals from the Metacardis European cross-sectional study, we created a non-exhaustive composite lifestyle score (QASD score) incorporating diet quality and diversity, physical activity, and smoking.The QASD score shows substantial explanatory power for microbiome composition variation compared to individual lifestyle variables. It positively associates with microbiome genetic richness, butyrate-producing bacteria, and serum metabolites like Hippurate linked to genetic richness and metabolic health. Conversely, it inversely associates with Clostridium bolteae and Ruminococcus gnavus, as well as serum branched-chain amino acids and dipeptides observed in chronic diseases.Causal inference analyses identify 135 cases where the gut microbiome mediates >20% of QASD score effects on the host metabolome. Microbial gene richness emerges as a strong mediator in the QASD score's impact on markers of host glucose metabolism (e.g. 27.3% of the effect on HOMA-IR), despite bidirectional associations between the microbiome and host clinical phenotypes. This study emphasizes the importance of combining lifestyle factors to understand their collective contribution to the gut microbiota and the mediating effects of the gut microbiota on the impact of lifestyle on host metabolic phenotype and metabolomic profiles.

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Section: Resultsmentioning

confidence: 99%

The Gut Microbiome Strongly Mediates the impact of Lifestyle combined variables on Cardiometabolic Phenotypes

Adriouch,

Belda,

Swartz

et al. 2024

Preprint

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“…As dietary patterns influence intestinal microbiota, they could also influence health status. Numerous studies have shown that carotenoids can influence intestinal microbiota in various ways [ 210 ]. First, research has shown that carotenoids alter the expression of immunoglobulin A, which is a very important factor in bacterial colonization [ 211 ].…”

Section: Dietary Carotenoids In Depressionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview

Rasmus

Kozłowska

2023

Antioxidants

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Depression has a multifactorial etiology comprising family history and unemployment. This review aims to summarize the evidence available for the antioxidant and anti-inflammatory effects of carotenoids in mood disorders. This review article’s methodologies were based on a search of the PubMed database for all linked published papers. Epidemiological studies indicate that a diet rich in vegetables, fruits, nuts, fish, and olive oil may prevent the development of depression. Antioxidant supplementation has been found to combat various stress-induced psychiatric disorders, including depression and anxiety. A growing body of evidence indicates that carotenoids have both antioxidant and anti-inflammatory. Studies also suggest that poor dietary intake, particularly low intakes of fruit and vegetables and high intakes of fast food and other convenience foods, may increase the risk of developing depression. Thus, dietary interventions have the potential to help mitigate the risk of mental health decline in both the general population and those with mood disorders. Considering that carotenoids have both antioxidant and anti-inflammatory effects, it is expected that they might exert a promising antidepressant effect. Nevertheless, further studies (including interventional and mechanistic studies) assessing the effect of carotenoids on preventing and alleviating depression symptoms are needed.

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“…The reasons why carotenoids play a role can be summarized as follows: (a) carotenoids have been related to a number of health benefits, which have originally been ascribed to their anti-inflammatory and antioxidant properties; 6,7 (b) IBD is closely linked to gut barrier functionality, and potential interactions of carotenoids with gut microbiota have been highlighted; 8 (c) researches have shown that patients with UC have decreased levels of β-carotene in their serum; 9,10 (d) carotenoids largely bypass absorption in the small intestine and are transmitted to the colon. 11 However, these pigments have a hydrophobic nature, which results in their low solubility in water. Additionally, they are highly susceptible to degradation by factors such as light, heat, oxygen, or acids.…”

Section: Introductionmentioning

confidence: 99%

Structure–property relationship of pea protein fibrils in stabilization of HIPEs and the encapsulation, protection, controlled release and oral delivery of carotenoids for alleviating intestinal inflammation

Liu,

Zhang,

Zhao

et al. 2024

Food Funct.

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Carotenoids and Their Health Benefits as Derived via Their Interactions with Gut Microbiota

Cited by 33 publications

References 190 publications

The Gut Microbiome Strongly Mediates the impact of Lifestyle combined variables on Cardiometabolic Phenotypes

The Gut Microbiome Strongly Mediates the impact of Lifestyle combined variables on Cardiometabolic Phenotypes

Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview

Structure–property relationship of pea protein fibrils in stabilization of HIPEs and the encapsulation, protection, controlled release and oral delivery of carotenoids for alleviating intestinal inflammation

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