Carotenoids and lung cancer prevention

An Overview of Carotenoids, Apocarotenoids, and Vitamin A in Agro‐Food, Nutrition, Health, and Disease

“…In this regard, evidence is accumulating that the oxidative metabolites of carotenoids can exert beneficial or detrimental effects depending on factors including their levels that are largely dependent on the dose administered and the tissue deposition of carotenoids and their derivatives. More detailed information on the role of β‐carotene and other carotenoids in lung cancer prevention as well as mechanistic aspects can be found in the excellent review by Veeramachaneni and Wang …”

“…More detailed information on the role of β-carotene and other carotenoids in lung cancer prevention as well as mechanistic aspects can be found in the excellent review by Veeramachaneni and Wang. [141] Retinoid Toxicity: Given its importance in diverse processes, VA homeostasis is tightly controlled at different locations (including intestine, liver, eye, adipose tissue, and heart) such that the plasma levels of retinol are maintained in a narrow range to avoid toxicity. [53,[142][143][144] As far as the conversion of PAC into vitamin A is concerned, the intestine-specific transcription factor ISX acts as a gatekeeper that controls not only carotenoid absorption but also their conversion to vitamin A.…”

Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair

“…Previous studies have shown that lycopene supplementation attenuated cell proliferation and growth, DNA damage, and insulin-like growth factor-1 stimulated growth [ 24 ]. However, the role of lycopene in smoke-induced oxidative stress was still unclear.…”

“…In addition, lycopene and its metabolites (i.e., acycloretinoic acid and apo-10′-lycopenoic acid) have been shown to activate retinoic acid receptor β (RARβ), leading to reduced cell proliferation [ 19 , 20 , 21 ], increased apoptosis [ 22 ], and enhanced gap junction communication (GJC) by upregulating connexin-43 (Cx43) [ 23 ]. Nevertheless, fewer studies have examined the effects of lycopene supplementation on lung cancer and the underlying molecular mechanisms [ 24 ].…”

Συμβολή στον χαρακτηρισμό και στη διερεύνηση βιολογικών ιδιοτήτων των στύλων ειδών γένους crocus

“…Ολικό εκχύλισμα κρόκου σε συγκέντρωση 0.56 g/kg αρουραίων βρέθηκε να αυξάνει την διάρκεια του ύπνου ενώ η σαφρανάλη δρα αγχολυτικά σε συγκεντρώσεις 0.15 και 0.35 mL/kg αρουραίων [Hosseinzadeh and Noraei 2009]. Έρευνες αποδίδουν επίσης στον κρόκο θετική δράση σε ασθενείς με ήπια προς μέτρια κατάθλιψη ύστερα από ημερήσια χορήγηση (30 mg/ημέρα) για 22 εβδομάδες [Akhondzadeh et al 2004;Akhondzadeh et al 2009] ενώ ο Wang και οι συνεργάτες του απέδωσαν την αντικαταθλιπτική αυτή δράση στην κροκίνη [Wang et al 2009].…”