Carotenoid and tocopherol concentrations in plasma, peripheral blood mononuclear cells, and red blood cells after long-term beta-carotene supplementation in men

Fotouhi, Nader; Meydani, Mohsen; Santos, M S; Meydani, Simin Nikbin; Hennekens, Charles H.; Gaziano, J. Michael

doi:10.1093/ajcn/63.4.553

Cited by 72 publications

(30 citation statements)

References 23 publications

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“…This observation was in agreement with the study of Fotouhi et al (1996) that previously demonstrated that carotenoid concentrations of plasma did not always correlate with the protection of RBCs.…”

Section: Evaluation Of Fsmp Efficacy As Therapy Adjuvantsupporting

confidence: 93%

Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection

et al. 2006

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Objective: The present study aimed to develop a food for special medical purposes (FSMP) and to assess its efficacy as adjuvant therapy in patients with chronic hepatitis C virus (HCV). Design: Open randomized clinical trials with a tomato-based FSMP used as adjuvant treatment to the pharmacological therapy with pegilated interferon and ribavirin. Subjects: Eight healthy volunteers and 39 HCV patients. Interventions: For the bioavailability study, healthy subjects consumed 100 g/die FSMP for a week and their serum carotenoid profile at baseline, after the week of administration and 7 days later was determined. The same quantity of FSMP for 6 months by 20 of the 39 HCV patients was consumed in the clinical trial. Serum transaminase, haemoglobin (Hb) and hydroperoxide concentrations during the therapy were monitored in all patients. Results: FSMP consumption caused a fourfold increase of lycopene serum concentration in healthy subjects. A significant increase of carotenoids after 1 month of consumption also in patients with HCV was recorded. Transaminase and Hb serum levels, as well as therapeutic response, were not influenced by FSMP. The decrease in serum hydroperoxides was independent from FSMP consumption in long-term responder patients, whereas nonresponder (NR) patients of FSMP group showed higher reductions than NR patients of Control group. Conclusions: The FSMP was effective in improving carotenoid status in healthy subjects. In HCV patients, it did not influence the therapeutic response, but it prevented carotenoid serum depletion and it was effective in improving the oxidative status during antiviral therapy in NR patients.

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Section: Evaluation Of Fsmp Efficacy As Therapy Adjuvantsupporting

confidence: 93%

Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection

et al. 2006

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“…It seems unlikely that an inadequate dosage of beta carotene explains the null findings. The dose used in this study (50 mg on alternate days) increased plasma beta carotene concentration approximately fourfold (18,19), (similar to the increase in beta carotene concentration observed in AREDS [13]), and placed men in the beta carotene group in the top few percentiles of the general population with respect to usual intake. It also seems unlikely that the duration of treatment of 12 years was insufficient to materially reduce risks of ARM.…”

Section: Discussionsupporting

confidence: 70%

Beta Carotene Supplementation and Age-Related Maculopathy in a Randomized Trial of US Physicians

Christen

Manson²,

Glynn³

et al. 2007

Arch Ophthalmol

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Objective-To test whether beta carotene affects age-related maculopathy (ARM) in a large-scale randomized trial.Design-Randomized, double-masked, placebo-controlled trial among 22,071 apparently healthy male U.S physicians aged 40 to 84 years. Participants were randomly assigned to receive beta carotene (50 mg on alternate days) or placebo.Main Outcome Measure-Incident ARM responsible for a reduction in best-corrected visual acuity to 20/30 or worse. Results-After 12 years of treatment and follow-up, there were 162 cases of ARM in the beta carotene group and 170 cases in the placebo group (relative risk [RR], 0.96; 95 percent confidence interval [CI], 0.78 to 1.20). The results were similar for the secondary endpoints of ARM with or without vision loss (275 cases versus 274 cases; RR, 1.01; CI, 0.86 to 1.20) and advanced ARM (63 cases versus 66 cases; RR, 0.97; CI, 0.69 to 1.37).Conclusions-These randomized data with 12 years of treatment in a large population of apparently healthy men indicate that beta carotene supplementation has no beneficial or harmful effect on incidence of ARM.Applications to Clinical Practice-Long-term supplemental use of beta carotene neither decreases nor increases the risk of ARM.

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“…Similarly, lycopene content of LDL was decreased after 6 d supplementation with 100 mg bcarotene (Gaziano et al, 1995b). In contrast long-time supplementation (12 y) did not affect concentration of other carotenoids (Fotouhi et al, 1996). Interestingly, the plasma concentrations reported by Fotouhi and coworkers were very similar to those observed in Austrians (mmol/L: 0.39 vs 0.32 for lycopene, 0.28 vs 0.32 for b-crypthoxanthin, and 0.44 vs 0.47 for lutein zeaxanthin, respectively) and therefore substantially lower than in Iranians.…”

Section: Enhanced Plasma Level Of Lipid Peroxidation S Meraji Et Almentioning

confidence: 85%

Enhanced plasma level of lipid peroxidation in Iranians could be improved by antioxidants supplementation

Meraji¹,

Ziouzenkova²,

Resch³

et al. 1997

Eur J Clin Nutr

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Objective: To study the in¯uence of supplementation with antioxidants on factors, which might increase the risk of coronary heart disease (CHD) in Iranians. Design: Twenty-one male volunteers enter the prospective, single-blind, randomized study. Setting: The supplementation was conducted at the Cardiovascular Center, University of Tehran, the biochemical analysis were carried out in the University of Graz. Subjects: Twenty-one male medical students were recruited by advertisement. Five subjects were dropped out due to lack of the compliance. Methods: One group of Iranians received 30 mg/d b-carotene and placebo for a-tocopherol; the other received b-carotene plus 400 IU a-tocopherol for ten weeks. Concentrations of antioxidants in plasma and low density lipoproteins (LDL), plasma lipid pro®le, autoantibody against oxidized LDL (oLAb) and malondialdehyde (MDA) concentrations in plasma were measured. Oxidative resistance of LDL was estimated using conjugated diene assay. Results: Iranians had a signi®cantly lower plasma levels of total cholesterol (P`0.002), LDL-cholesterol (P`0.01) and high density lipoprotein-cholesterol (P`0.002), compared to healthy Austrian subjects (n 13). Although the baseline concentrations of a-tocopherol and b-carotene were comparable with Austrians, lycopene, canthaxanthin and lutein were signi®cantly higher in Iranians (P`0.03±0.001). In vitro oxidative resistance of LDL, measured as lag-time, was slightly higher (P`0.01) in Iranians comparing with Austrians. Plasma MDA and oLAb concentrations were signi®cantly higher in Iranians (P`0.001). Both dietary supplementations reduced plasma MDA concentrations (P`0.001±0.001). A key ®nding was that a supplement combined with atocopherol caused also a signi®cant increase of oLAb concentration (P b 0.01) as well as the signi®cant increase of lag-time (P b 0.005). Conclusions: This study shows that high plasma MDA level of Iranians can be decreased by b-carotene supplementation with or without a-tocopherol. However, a-tocopherol is a more powerful antioxidant, which can increase the resistance of LDL to oxidation, reduce the MDA concentrations in plasma and increase autoantibodies to oLDL.

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Carotenoid and tocopherol concentrations in plasma, peripheral blood mononuclear cells, and red blood cells after long-term beta-carotene supplementation in men

Cited by 72 publications

References 23 publications

Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection

Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection

Beta Carotene Supplementation and Age-Related Maculopathy in a Randomized Trial of US Physicians

Enhanced plasma level of lipid peroxidation in Iranians could be improved by antioxidants supplementation

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