Caroli's disease: A premalignant condition?

Dayton, Merril T.; Longmire, William P.; Tompkins, Ronald K.

doi:10.1016/0002-9610(83)90164-2

Cited by 161 publications

(69 citation statements)

References 38 publications

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“…CCA is a more serious complication of CD.Occurrence of CCA in CD is 100 times greater than that in the general population with a reported incidence of 7-14% [8,9]. CCA is more commonly identified in men with age more than 50 yrs.…”

Section: Discussionmentioning

confidence: 99%

Monolobar Caroli`S Disease with Intrahepatic Cholangiocarcinoma–Diagnostic Dilemma in A Cystic Lesion of Liver

Gr¹,

Prabhaharan²,

Balaguru³

et al. 2017

IOSR JDMS

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Section: Discussionmentioning

confidence: 99%

Monolobar Caroli`S Disease with Intrahepatic Cholangiocarcinoma–Diagnostic Dilemma in A Cystic Lesion of Liver

Gr¹,

Prabhaharan²,

Balaguru³

et al. 2017

IOSR JDMS

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“…In the presence of intrahepatic biliary lithiasis, maneuvers to remove all stones are required as long as they predispose secondary complications. Beside recurrent cholangitis or liver abscess, an increased risk of malignant transformation has been described [8,9]. Although the etiology is yet unknown, an association with ductal plate malformations has been shown [10], and an incidence of cholangiocarcinoma of 7-10% was reported [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Beside recurrent cholangitis or liver abscess, an increased risk of malignant transformation has been described [8,9]. Although the etiology is yet unknown, an association with ductal plate malformations has been shown [10], and an incidence of cholangiocarcinoma of 7-10% was reported [8,9]. In theory, malignant transformation is probably triggered by long-standing inflammation and chronic injury of the biliary epithelium which could be explained by continuous and moderate stone movement as well as by the persistence of bacteria in dilated bile ducts.…”

Section: Discussionmentioning

confidence: 99%

Interdisciplinary Treatment of Bilobular Caroli’s Syndrome by Side-To-Side Choledochoduodenostomy and Subsequent Endoscopic Stone Removal

Gäbelein¹,

Glanemann²,

Adler

et al. 2006

Visc Med

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Therapy of Caroli’s syndrome usually consists of endoscopic stone removal in order to achieve adequate bile flow and to avoid secondary complications such as cholangitis or deterioration of liver function. If primary endoscopic treatment is not sufficient, liver resection or transplantation could become necessary to achieve a stone-free situation. Case Report: We herein describe a case of bilobular Caroli’s syndrome which was primarily endoscopically treated. Due to a common bile duct stricture after cholecystectomy and choledochotomy 10 years before, endoscopic stone removal was impossible. Instead of liver resection or transplantation, we performed a wide side-to-side choledochoduodenostomy which allowed subsequent endoscopic treatment with successful removal of all bile duct stones during repeated sessions. Six years after surgery, no further episodes of cholangitis have occurred, and the patient has fully recovered with normal liver function. Conclusion: Even bilobular Caroli’s syndrome refractory to primary endoscopic treatment might be removed using an interdisciplinary approach thereby successfully avoiding liver resection or transplantation.

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“…Internal biliary drainage, especially choledocojejunostomy, has been the most common surgical treatment for the diffuse forms of Caroli's disease, although these surgical procedures often result in incomplete drainage of the biliary tree and a very high morbidity [6,211. Hepatic resection has been successfully performed in localized or monolobar forms [lo, [15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Liver transplantation in patients with Caroli's disease and recurrent cholangitis

Sans¹,

Rimola²,

Navasa³

et al. 1997

Transplant Int

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. Caroli's disease is an uncommon congenital disorder of the intrahepatic biliary tree. It is characterized by multiple and segmental dilatations of the bile ducts. The clinical course of Caroli's disease is often complicated by recurrent episodes of bacterial cholangitis that seriously impair the patient's quality of life. Despite wide spectrum antimicrobial agents, medical treatment of cholangitis is frequently unsuccessful in patients with Caroli's disease due to the persistence of bacteria in dilatated bile ducts. Other therapies, including internal or external biliary drainages and various surgical or endoscopic procedures, have been used in the treatment of Caroli's disease, with poor results. There are no previous reports in the literature of liver transplantation for recurrent cholangitis in patients with Caroli's disease. We present two such cases, in which cholangitis is resolved.

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Caroli's disease: A premalignant condition?

Cited by 161 publications

References 38 publications

Monolobar Caroli`S Disease with Intrahepatic Cholangiocarcinoma–Diagnostic Dilemma in A Cystic Lesion of Liver

Monolobar Caroli`S Disease with Intrahepatic Cholangiocarcinoma–Diagnostic Dilemma in A Cystic Lesion of Liver

Interdisciplinary Treatment of Bilobular Caroli’s Syndrome by Side-To-Side Choledochoduodenostomy and Subsequent Endoscopic Stone Removal

Liver transplantation in patients with Caroli's disease and recurrent cholangitis

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