Carob pods (Ceratonia siliqua L.) inhibit human neutrophils myeloperoxidase and in vitro ROS-scavenging activity

Abstract

Chromatographic profiles of aqueous extract of carob pods ((A) pulp and (B) seeds).

Ceratonia siliqua L. (immature carob bean) inhibits intestinal glucose absorption, improves glucose tolerance and protects against alloxan‐induced diabetes in rat

“…This difference seems to take place according to its degree of maturity. Thus many compounds such as chlorogenic acid, epicatechin, vanillic acid and coumarin are found particularly in immature pulp of carob compared to the mature pulp …”

“…These compounds are known to exert a variety of physiological effects, including improved digestion and attenuation of blood cholesterol and glucose levels . Water extracts of carob pods show high antioxidative activity and free radical scavenging activity (RSA) in vitro . However, until now, little attention has been paid to the effects of the plant on intestinal glucose absorption.…”

“…18,19 Water extracts of carob pods show high antioxidative activity 20 and free radical scavenging activity (RSA) in vitro. 21 However, until now, little attention has been paid to the effects of the plant on intestinal glucose absorption. In this respect, the present study investigated the potential effect of immature carob pod aqueous extract (ICPAE) to decrease intestinal glucose absorption in vitro by using an Ussing chamber and to treat hyperglycemia and symptoms of alloxan-induced diabetes in vivo.…”

Farklı Oranlarda Keçiboynuzu Unu İçeren Pestillerin Bazı Fiziksel, Kimyasal ve Duyusal Özelliklerinin Belirlenmesi

“…Toplam kuru maddesi yaklaşık %91-92 oranında olan keçiboynuzu meyvesinde %62-67 oranında şeker, %4-6 protein, %0,2-0,4 ham yağ, %2-3 kül, %4,6-6,2 ham selüloz ve diğer maddeler bulunmaktadır (Karkacıer ve Artık, 1995). Keçiboynuzu meyvesi tüketiminin antioksidan, anti-ishal, antibakteriyel, antiülser ve anti-inflamatuar etkileri de dahil olmak üzere özellikle sindirim sistemi üzerine farmakolojik etkilerinin bulunduğu kanıtlanmıştır (Rtibi et al, 2015a;Rtibi et al, 2016a;Rtibi et al, 2016b;Kivçak ve ark., 2002;Rtibi et al, 2015b;Rtibi et al, 2016c;Rtibi et al, 2017). Besleyici değeri ve sağlık etkileri bu derece yüksek olan keçiboynuzundan kek, pasta, ekmek, makarna, çikolata, peynir, dondurma, meyve jölesi ve marmelat yapımında faydalanılmaktadır (Kirk ve Othmer, 1967;Yurdagel ve Teke, 1985).…”

CAROB (Ceratonia siliqua): HEALTH, MEDICINE, CHEMISTRY

“…77 Aqueous extract of dry pods (or leaves) was prepared and found active inhibitor of neutrophils myeloperoxidase. 78,79 Dry leaves aqueous extract was found protective against cell DNA oxidative stress caused by H2O2 and it had no genotoxicity. 80 Fresh pulp was extracted by ultrasonic-assisted 80 % aqueous ethanol.…”