“…S16 ). It has been proposed in a study, combining experimental and MD approaches, to potentially contribute to the inhibition mechanism by forming H-bond with carnosine, an endogenous dipeptide suggested to inhibit P-gp activity [91] . On the other hand, W232 appears to recruit and stabilize ligands within the binding pocket, a mechanism similar to that observed for the phospholipid translocation process of ABCB4, sharing 75 % of sequence identity with P-gp [66] .…”