Carnosine ameliorates liver fibrosis and hyperammonemia in cirrhotic rats

Jamshidzadeh, Akram; Heidari, Reza; Latifpour, Zahra; Ommati, Mohammad Mehdi; Abdoli, Narges; Mousavi, Somayeh; Azarpira, Negar; Zarei, Azita; Zarei, Mahdi; Asadi, Behnam; Abasvali, Mojgan; Yeganeh, Yasaman; Jafari, Faezeh; Saeedi, Arastoo; Najibi, Asma; Mardani, Elnaz

doi:10.1016/j.clinre.2016.12.010

Cited by 44 publications

(25 citation statements)

References 78 publications

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“…Much research has demonstrated the beneficial effects of dietary supplementation with carnosine on animal models of human diseases (Derave et al 2019). These effects include decreased plasma glucose and amelioration of diabetic complications (e.g., nephropathy, ocular damage, and retinopathy) in diabetic mice (Lee et al 2005;Pfister et al 2011); reduced lipid oxidation and augmented anti-oxidative capacities [e.g., restoring of blood glutathione and basal activities of antioxidant enzymes in aging rats (Aydin et al 2010a,b;Hipkiss and Brownson 2000)] and in pigs (Ma et al 2010); amelioration of acetaminophen-induced liver injury (Yan et al 2009), thioacetamide-or hyperammonemia-induced liver cirrhosis (Aydin et al 2010a,b;Jamshidzadeh et al 2017b), and ethanol-induced chronic liver injury in rats (Liu et al 2008). Dietary supplementation with carnosine also results in decreases in malondialdehyde, oxidative stress (including ischemic oxidative stress and cerebral ischemia), and ethanol-induced protein carbonyls in brains (Berezhnoy et al 2019;Fedorova et al 2018); amelioration of neurological disorders, including autism spectrum disorder in children (Chez et al 2002;Kawahara et al 2018); protection against cardiovascular injury (Abplanalp et al 2019;Artioli et al 2019) and bleomycin-induced lung fibrosis in rats (Cuzzocrea et al 2007); cardiomyopathy in rats induced by chemotherapeutic agents that cause hydroxyl radical formation and lipid peroxidation (Dursun et al 2011); ROS-induced renal damage in mice (Fouad et al 2008); and promotion of wound healing in rodents (Ansurudeen et al 2012).…”

Section: Health Benefits Of Carnosine Supplementationmentioning

confidence: 99%

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

2020

Amino Acids

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Taurine (a sulfur-containing β-amino acid), creatine (a metabolite of arginine, glycine and methionine), carnosine (a dipeptide; β-alanyl-l-histidine), and 4-hydroxyproline (an imino acid; also often referred to as an amino acid) were discovered in cattle, and the discovery of anserine (a methylated product of carnosine; β-alanyl-1-methyl-l-histidine) also originated with cattle. These five nutrients are highly abundant in beef, and have important physiological roles in anti-oxidative and antiinflammatory reactions, as well as neurological, muscular, retinal, immunological and cardiovascular function. Of particular note, taurine, carnosine, anserine, and creatine are absent from plants, and hydroxyproline is negligible in many plant-source foods. Consumption of 30 g dry beef can fully meet daily physiological needs of the healthy 70-kg adult human for taurine and carnosine, and can also provide large amounts of creatine, anserine and 4-hydroxyproline to improve human nutrition and health, including metabolic, retinal, immunological, muscular, cartilage, neurological, and cardiovascular health. The present review provides the public with the much-needed knowledge of nutritionally and physiologically significant amino acids, dipeptides and creatine in animal-source foods (including beef). Dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline are beneficial for preventing and treating obesity, cardiovascular dysfunction, and ageing-related disorders, as well as inhibiting tumorigenesis, improving skin and bone health, ameliorating neurological abnormalities, and promoting well being in infants, children and adults. Furthermore, these nutrients may promote the immunological defense of humans against infections by bacteria, fungi, parasites, and viruses (including coronavirus) through enhancing the metabolism and functions of monocytes, macrophages, and other cells of the immune system. Red meat (including beef) is a functional food for optimizing human growth, development and health.

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Section: Health Benefits Of Carnosine Supplementationmentioning

confidence: 99%

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

2020

Amino Acids

331

192

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“…Although the protective properties of taurine have been widely investigated, the effect of this chemical against hyperammonemia-associated complications such as impairment of locomotor activity and brain injury has not been entirely revealed. In the current study, bile duct ligation (BDL) was used as a reliable animal model of cirrhosis [ 37 , 38 ]. Then, plasma biomarkers of liver injury were assessed.…”

Section: Introductionmentioning

confidence: 99%

Taurine supplementation abates cirrhosis-associated locomotor dysfunction

Heidari

Jamshidzadeh

Ghanbarinejad

et al. 2018

ceh

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Aim of the studyHepatic encephalopathy and hyperammonemia is a clinical complication associated with liver cirrhosis. The brain is the target organ for ammonia toxicity. Ammonia-induced brain injury is related to oxidative stress, locomotor activity dysfunction, and cognitive deficit, which could lead to permanent brain injury, coma and death if not appropriately managed. There is no promising pharmacological intervention against cirrhosis-associated brain injury. Taurine (TAU) is one of the most abundant amino acids in the human body. Several physiological and pharmacological roles have been attributed to TAU. TAU may act as an antioxidant and is an excellent neuroprotective agent. This study aimed to evaluate the effect of TAU supplementation on cirrhosis-associated locomotor activity disturbances and oxidative stress in the brain.Material and methodsRats underwent bile duct ligation (BDL) surgery, and plasma and brain ammonia level, plasma biochemical parameters, and rats’ locomotor function were monitored. Furthermore, brain tissue markers of oxidative stress were assessed.ResultsIt was found that plasma and brain ammonia was increased, and markers of liver injury were significantly elevated in the cirrhotic group. Impaired locomotor activity was also evident in BDL rats. Moreover, an increase in brain tissue markers of oxidative stress was detected in the brain of cirrhotic animals. It was found that TAU supplementation (50, 100, and 200 mg/kg, gavage) alleviated brain tissue markers of oxidative stress and improved animals’ locomotor activity.ConclusionsThese data suggest that TAU is a potential protective agent against cirrhosis-associated brain injury.

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“…This peptide plays a variety of biological and -Cytotoxicity -Drug-induced liver injury -Hepatotoxicity -Mitochondria -Oxidative stress -Antioxidants physiological functions including membrane protecting activity, metal chelating ability, pH-buffering, protection against proteins glycation and macrophage regulating activities. [16][17][18] Antioxidative and radical scavenging properties are also interesting features of CAR molecule. 19 Recently, it has been shown that carnosine has promising preclinical and clinical effects in several disease including diabetes, ocular disease, aging, cancer and neurological disorders.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, CAR efficiently attenuates liver damages with different etiologies. 17,[21][22][23][24][25][26] The current study was designed to evaluate the potential protective properties of CAR against INH-induced toxicity in primary rat hepatocyte culture.…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective Properties of Carnosine against Isoniazid-Induced Toxicity in Primary Cultured Rat Hepatocytes

et al. 2018

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Background: Drug-induced liver injury is a critical clinical complication. Hence, finding new and safe protective agents with potential clinical application is of value. Isoniazid (INH) is an antituberculosis agent widely used against Mycobacterium tuberculosis infection in human. On the other hand, hepatotoxicity is a clinical complication associated with isoniazid therapy. Oxidative stress and its associated events are major mechanisms identified for INH-induced liver injury. Carnosine is an endogenously found peptide widely investigated for its hepatoprotective effects. On the other hand, robust antioxidant and cytoprotective effects have been attributed to this peptide. Methods: The current study designed to evaluate the potential cytoprotective properties of carnosine against INH-induced cytotoxicity in drug-exposed primary cultured rat hepatocytes. Primary cultured rat hepatocytes were incubated with INH (1.2 mM). Results: INH treatment caused significant increase in cell death and lactate dehydrogenase (LDH) release. On the other hand, it was found that markers of oxidative stress including reactive oxygen species were significantly increased in INH-treated cells. Cellular glutathione reservoirs were also depleted in INH-treated group. Carnosine treatment (50 and 100 µM) significantly diminished INH-induced oxidative stress and cytotoxicity. Conclusion: These data mention carnosine as a potential protective agent with therapeutic capability against INH hepatotoxicity.

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Carnosine ameliorates liver fibrosis and hyperammonemia in cirrhotic rats

Cited by 44 publications

References 78 publications

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

Taurine supplementation abates cirrhosis-associated locomotor dysfunction

Cytoprotective Properties of Carnosine against Isoniazid-Induced Toxicity in Primary Cultured Rat Hepatocytes

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