Carnosinases, Their Substrates and Diseases

Bellia, Francesco; Vecchio, Graziella; Rizzarelli, Enrico

doi:10.3390/molecules19022299

Cited by 82 publications

(84 citation statements)

References 181 publications

(269 reference statements)

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“…Carnosinase (CNDP1) hydrolyzes carnosine, which has been described to have neuroprotective effects due to its capacity to decrease oxidative stress and inflammation (38,39). Although carnosinase activity has been associated with several neurological disorders and its potential use as a CSF biomarker has been proposed (40), its specific role in multiple sclerosis remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Protein-Based Classifier to Predict Conversion from Clinically Isolated Syndrome to Multiple Sclerosis

Borràs

Cantó

Choi

et al. 2016

Molecular & Cellular Proteomics

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Section: Discussionmentioning

confidence: 99%

Protein-Based Classifier to Predict Conversion from Clinically Isolated Syndrome to Multiple Sclerosis

Borràs

Cantó

Choi

et al. 2016

Molecular & Cellular Proteomics

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“…Although the effect of each SNP and dietary factor is small, the combined effect of the genetic and dietary factor is rather strong. CNDP1 and CNDP2 are dipeptidases that are related to the metabolism of carnosine or GSH, respectively [10,11,14,15], which are the most abundant naturally occurring endogenous dipeptide and tripeptide with antioxidant and free radical scavenger properties, respectively [11,12,13,16]. In addition, CNDP2 seems to be a Cys-Gly peptidase of the γ-glutamyl cycle.…”

Section: Discussionmentioning

confidence: 99%

“…Carnosine is selectively hydrolyzed by carnosinase 1 (CNDP1). Additionally, humans have another dipeptidase homologous to CNDP1, cellular nonspecific dipeptidase (CNDP2), which exhibits a broad specificity toward various dipeptides [11,14]. Although the precise function of CNDP2 has not been defined, it may be a Cys-Gly peptidase of the γ-glutamyl cycle and could play an important role in glutathione (GSH) metabolism [15].…”

Section: Introductionmentioning

confidence: 99%

“…Carnosine is the most abundant dipeptide and plays an important role in humans [10,11,12,13]. Carnosine is selectively hydrolyzed by carnosinase 1 (CNDP1).…”

Section: Introductionmentioning

confidence: 99%

“…Naturally occurring endogenous dipeptides containing histidine, such as carnosine, anserine, and homocarnosine, have antioxidant and free radical scavenging properties [10,11,12]. Carnosine is the most abundant dipeptide and plays an important role in humans [10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

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The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk

Yamakawa‐Kobayashi

Otagi²,

Ohhara³

et al. 2017

Lifestyle Genomics

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Background/Aims: It is possible that carnosinase (CNDP1) and cellular nonspecific dipeptidase (CNDP2) have important roles in protecting cells and tissues against the damage of oxidative stress. Oxidative stress and subsequent inflammation are key factors in the development of common chronic metabolic diseases, such as obesity. We aimed to investigate the combined effects of genetic variations in CNDP1 and CNDP2 and dietary carbohydrate and carotene intake on obesity risk. Methods: A total of 1,059 Japanese men were randomly selected from participants who visited a medical center for routine medical checkups. We analyzed the relationships between the genotypes of 4 single-nucleotide polymorphisms (SNPs) (rs12605520, rs7244647, rs4891558, and rs17089368) in the CNDP1/CNDP2 locus and body mass index or prevalence of obesity/overweight taking into account dietary carbohydrate and carotene intake. Results: We found that 2 SNPs (rs7244647 in CNDP1 and rs4891558 in CNDP2) were associated with obesity risk. In addition, these associations were observed only in the group with high carbohydrate and low carotene intake but not in the group with low carbohydrate and high carotene intake. Conclusions: Our findings indicate that the combination of genetic variations in CNDP1 and CNDP2 and dietary carbohydrate/carotene intake modulate obesity risk.

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Carnoquinolines Target Copper Dyshomeostasis, Aberrant Protein–Protein Interactions, and Oxidative Stress

Bellia

Grasso

Ahmed

et al. 2020

Chemistry A European J

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Metal dysregulation, oxidative stress, protein modification, and aggregation are factors strictly interrelated and associated with neurodegenerative pathologies. As such, all of these aspects represent valid targets to counteract neurodegeneration and, therefore, the development of metal‐binding compounds with other properties to combat multifactorial disorders is definitely on the rise. Herein, the synthesis and in‐depth analysis of the first hybrids of carnosine and 8‐hydroxyquinoline, carnoquinolines (CarHQs), which combine the properties of the dipeptide with those of 8‐hydroxyquinoline, are reported. CarHQs and their copper complexes were characterized through several techniques, such as ESI‐MS and NMR, UV/Vis, and circular dichroism spectroscopy. CarHQs can modulate self‐ and copper‐induced amyloid‐β aggregation. These hybrids combine the antioxidant activity of their parent compounds. Therefore, they can simultaneously scavenge free radicals and reactive carbonyl species, thanks to the phenolic group and imidazole ring. These results indicate that CarHQs are promising multifunctional candidates for neurodegenerative disorders and they are worthy of further studies.

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Carnosinases, Their Substrates and Diseases

Cited by 82 publications

References 181 publications

Protein-Based Classifier to Predict Conversion from Clinically Isolated Syndrome to Multiple Sclerosis

Protein-Based Classifier to Predict Conversion from Clinically Isolated Syndrome to Multiple Sclerosis

The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk

Carnoquinolines Target Copper Dyshomeostasis, Aberrant Protein–Protein Interactions, and Oxidative Stress

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