Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity

Sahu, Bidya Dhar; Rentam, Kiran Kumar Reddy; Putcha, Uday Kumar; Kuncha, Madhusudana; Vegi, Ganga Modi Naidu; Sistla, Ramakrishna

doi:10.1016/j.fct.2011.08.018

Cited by 99 publications

(71 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results showed that cisplatin decreases the antioxidant power, so that it increases the peroxidation damages of the body, whose results were fairly in accorded with some studies' (Sahu BD et al, 2011;Buldak RJ et al, 2012;Gupta RK et al, 2013;Zhao YM et al, 2014). In this experiment, the oxidative stress indices in the pu-erh tea related groups changed to some extent compared to the cisplatin group, including the activities of SOD and GSH-PX and the levels of GSH were increased, while the levels of MDA were decreased.…”

Section: Discussionsupporting

confidence: 76%

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Zheng¹,

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Asian Pac J Cancer Prev, 15 (17), 7389-7394 IntroductionChemotherapy is one of the major means for malignancy. It seeks to shrink tumors, decrease cancerrelated symptoms, advance quality of life, lengthen life spans of patients, and so on. Many studies have shown the effectiveness and feasibility of chemotherapy for cancers species involving the lung, pancreas, liver, large intestine, and so on. Conversely, treatment with anticancer drugs can also do harm to patients' normal tissues and organs, and those toxicities may lead to a worsened quality of life and shortened survival.Cisplatin (cis-diamminedichloroplatinumⅡ, CDDP) is one of the main chemotherapeutics, which is widely used for the treatment of various malignant solid tumors such as ovarian, lung, testicular and head and neck cancers (Pfister et al., 2010;Dimri et al., 2013; Dua et al., 2013;Besse et al., 2014 AbstractBackground: Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings. Materials and Methods: The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices. Results: Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in camparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent. Conclusion: Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).

show abstract

Section: Discussionsupporting

confidence: 76%

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Zheng¹,

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Based on previous studies of Sahu et al (2011Sahu et al ( , 2013, nephro-and hepatotoxicity were induced by intraperitoneal (i.p.) administration of cisplatin dissolved in normal saline at the dose of 7.5 mg per kg body weight (b.w.).…”

Section: Cisplatin Toxicity Experimental Designmentioning

confidence: 99%

The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin

Katanić

Mihailović

Matić

et al. 2015

Journal of Functional Foods

View full text Add to dashboard Cite

“…Control animals were treated with corn oil (a vehicle for curcumin) in the same way. The doses of curcumin 4 and cisplatin 20 were chosen on the basis of previously published studies. Forty-eight hours after cisplatin injection, under xylazine/ketamine anesthesia, cardiac blood and the right and left kidneys of all the animals were harvested.…”

Section: Experimental Protocolmentioning

confidence: 99%

Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis

2016

View full text Add to dashboard Cite

Curcumin has several biological functions particularly antioxidant and anti-inflammatory. The aims of this study are determination of the protective effects of curcumin on cisplatin-induced renal tubular cell apoptosis and related pathways in kidney. Eighteen male Wistar albino rats were randomly divided into three groups (n ¼ 6): the control, cisplatin (CP), and cisplatin þ curcumin (CP þ CUR). Acute renal damage was induced by single dose of cisplatin (7.5 mg/ kg) injected by intraperitoneally (i.p). The animals of curcumin-treated group were received daily 200 mg/kg curcumin per os (po), starting from 2 days before the injection of cisplatin to the day of sacrifice. Forty-eight hours after cisplatin injection, samples of cardiac blood and kidneys were harvested from the animals. In this study, the major finding is that curcumin treatment ameliorates the following conditions associated with cisplatin-induced nephrotoxicity: (1) the development of kidney injury (histopathology), (2) inflammatory responses [myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-a), interleukin-1 beta (IL-1b), IL-6, IL-10 levels], (3) the degree of lipid peroxidation [malondialdehyde (MDA) level], (4) renal tubular cell apoptosis (active caspase-3) and expression of related proteins [p53, Fas, and Fas ligand (Fas-L)] by immunohistochemistry, (5) renal dysfunction (serum urea and creatinine). In a conclusion, this study suggests that curcumin has antiapoptotic effect against cisplatin nephrotoxicity, in addition to anti-inflammatory and antioxidant properties. ARTICLE HISTORY

show abstract

Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity

Cited by 99 publications

References 47 publications

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin

Curcumin counteracts cisplatin-induced nephrotoxicity by preventing renal tubular cell apoptosis

Contact Info

Product

Resources

About