Carnitine supplements for people with chronic kidney disease requiring dialysis

Nishioka, Norihiro; Luo, Yan; Taniguchi, Tetsuo; Ohnishi, Tsuyoshi; Kimachi, Miho; Ng, Roland C.K.; Watanabe, Norio

doi:10.1002/14651858.cd013601.pub2

Cited by 9 publications

(5 citation statements)

References 103 publications

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“…Thus, oral or intravenous supplementation of L-carnitine presents a potential therapy for correcting the abnormal metabolic reprogramming in these patients [134,135]. Several clinical randomized controlled trials of L-carnitine supplementation have been conducted in patients undergoing hemodialysis or peritoneal dialysis for chronic renal failure; however, the existing results are somewhat controversial [136][137][138][139][140].…”

Section: Kidney Failure Caused By Mitochondrial Respiratory Chain Abn...mentioning

confidence: 99%

Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure

Wang,

Yang,

Zhang

et al. 2024

IJMS

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The function of the respiratory chain is closely associated with kidney function, and the dysfunction of the respiratory chain is a primary pathophysiological change in chronic kidney failure. The incidence of chronic kidney failure caused by defects in respiratory-chain-related genes has frequently been overlooked. Correcting abnormal metabolic reprogramming, rescuing the “toxic respiratory chain”, and targeting the clearance of mitochondrial reactive oxygen species are potential therapies for treating chronic kidney failure. These treatments have shown promising results in slowing fibrosis and inflammation progression and improving kidney function in various animal models of chronic kidney failure and patients with chronic kidney disease (CKD). The mitochondrial respiratory chain is a key target worthy of attention in the treatment of chronic kidney failure. This review integrated research related to the mitochondrial respiratory chain and chronic kidney failure, primarily elucidating the pathological status of the mitochondrial respiratory chain in chronic kidney failure and potential therapeutic drugs. It provided new ideas for the treatment of kidney failure and promoted the development of drugs targeting the mitochondrial respiratory chain.

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Section: Kidney Failure Caused By Mitochondrial Respiratory Chain Abn...mentioning

confidence: 99%

Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure

Wang,

Yang,

Zhang

et al. 2024

IJMS

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“…In AKI, continuous renal replacement therapy is designed to maintain hydroelectrolyte balance and acid-base balance, as well as alleviate the symptoms of uremia in patients by continuously removing metabolites and fluids from the body [6]. Renal dialysis is the conventional strategy to treat advanced or the terminal-stage CKD [7]. Nevertheless, challenges remain in some uncontrolled cases, which dramatically increase the morbidity and mortality of the sufferers [8].…”

Section: Introductionmentioning

confidence: 99%

LRG1 Contributes to the Pathogenesis of Multiple Kidney Diseases: A Comprehensive Review

Chen,

Zhang,

et al. 2024

Kidney Dis

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Background: The increasing prevalence of kidney diseases has become a significant public health issue, with a global prevalence exceeding 10%. In order to accurately identify biochemical changes and treatment outcomes associated with kidney diseases, novel methods targeting specific genes have been discovered. Among these genes, leucine-rich α-2 glycoprotein 1 (LRG1) has been identified to function as a multifunctional pathogenic signaling molecule in multiple diseases, including kidney diseases. This study aims to provide a comprehensive overview of the current evidence regarding the roles of LRG1 in different types of kidney diseases. Summary: Based on a comprehensive review, it was found that LRG1 was up-regulated in the urine, serum, or renal tissues of patients or experimental animal models with multiple kidney diseases, such as diabetic nephropathy, kidney injury, IgA nephropathy, chronic kidney diseases (CKD), clear cell renal cell carcinoma (ccRCC), end-stage renal disease, canine leishmaniosis-induced kidney disease, kidney fibrosis, and aristolochic acid nephropathy. Mechanistically, the role of LRG1 in kidney diseases is believed to be detrimental, potentially through its regulation of various genes and signaling cascades, i.e. FN1, GPR56, VEGF, VEGFR-2, DR5, GDF15, HIF-1α, SPP1, ALK1-Smad1/5/8, NLRP3-IL-1b, and TGF-β pathway. Key Messages: Further research is needed to fully comprehend the molecular mechanisms by which LRG1 contributes to the pathogenesis and pathophysiology of kidney diseases. It is anticipated that targeted treatments focusing on LRG1 will be utilized in clinical trials and implemented in clinical practice in the future.

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“…Pharmacological therapy (i.e., Vitamin C and L-carnitine) has been proposed to relieve fatigue in patients with endstage renal disease undergoing hemodialysis (Borran et al, 2021;Nishioka et al, 2022). However, evidence regarding 1 MSN, RN, Doctoral Student, School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan, ROC • 2 PhD, RN, Lecturer, Faculty of Nursing, Chulalongkorn University, Bangkok, Thailand • 3 Methods: Four electronic databases were searched for qualified articles published between database inception and November 2, 2022.…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacological therapy (i.e., Vitamin C and L-carnitine) has been proposed to relieve fatigue in patients with end-stage renal disease undergoing hemodialysis (Borran et al, 2021; Nishioka et al, 2022). However, evidence regarding this and other pharmacological interventions have been inconclusive, leading patients to seek nonpharmacological alternatives such as exercise (Malini et al, 2022) to relieve posthemodialysis fatigue.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Acupressure for Fatigue Alleviation in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

CHANG,

ROMADLON,

CHEN

et al. 2024

Journal of Nursing Research

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Background Fatigue, a major health concern among patients receiving hemodialysis, is associated with poor quality of life, negative emotions, and cognitive dysfunction. Acupressure is a low-cost and noninvasive traditional Chinese therapy that has been widely used in community and clinic settings. However, the beneficial effects of acupressure on various aspects of fatigue among these patients have not been systematically investigated. Purpose This study was designed to determine the effects of acupressure on fatigue in patients receiving hemodialysis. The moderating influences of bio-sociodemographic characteristics and methodology on the association between acupressure and posthemodialysis fatigue were also examined. Methods Four electronic databases were searched for qualified articles published between database inception and November 2, 2022. Only randomized controlled trials designed to investigate the effects of acupressure on fatigue in patients receiving hemodialysis were qualified for consideration. A random-effects model was used for data analysis. Results Eight randomized controlled trials with 11 effect sizes and 725 participants were included in this study. In these studies, acupressure was found to have a significantly higher alleviation effect on general fatigue (g = −0.78; 95% confidence interval [−1.09, −0.48]) and the behavioral, emotional, sensory, and cognitive domains of fatigue (g = −0.51, −0.51, −0.72, and −0.41, respectively) among patients receiving hemodialysis than those in the control groups. Furthermore, the stimulation of the Shenmen acupoint was found to increase the effects (p < .01) of acupressure on fatigue reduction significantly. Notably, the use of special equipment to perform the acupressure was not found to significantly improve outcomes (p = .99). Conclusions/Implications for Practice Acupressure is effective in alleviating fatigue in patients receiving hemodialysis, particularly when the Shenmen acupoint is used together with other acupoints, and is effective without the application of special equipment. Acupressure may be adopted as a complementary therapy for fatigue alleviation in patients receiving hemodialysis. Based on the findings, healthcare providers should coach patients receiving hemodialysis with fatigue on how to use acupressure therapy appropriately to alleviate this health concern.

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Carnitine supplements for people with chronic kidney disease requiring dialysis

Cited by 9 publications

References 103 publications

Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure

Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure

LRG1 Contributes to the Pathogenesis of Multiple Kidney Diseases: A Comprehensive Review

Effectiveness of Acupressure for Fatigue Alleviation in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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