Carnitine depletion in the choline-deficient state

Corredor, Carlos; Mansbach, Charles M.; Bressler, Rubin

doi:10.1016/0005-2760(67)90165-8

Cited by 57 publications

(16 citation statements)

References 24 publications

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“…The results are consistent with those of CLirzon et al (8), who found lower HVA concentrations in CSF of patients with CSF blocks in the cervical region as compared to controls. The low values for FIVA in patients with CSF block also are consistent with animal studies showing no appreciable amounts of dopamine in the spinal cord (4)(5)(6).…”

supporting

confidence: 84%

Carnitine Deficiency of Human Skeletal Muscle with Associated Lipid Storage Myopathy: A New Syndrome

Engel

Angelini

1973

Science

478

115

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In a rare myopathy muscle fibers contained myriad lipid-filled vacuoles. Homogenates of the patient's muscle oxidized fatty acids more slowly than normal (11 controls). Addition of carnitine increased the oxidation rate with the patient's muscle to the level attained by the controls with carnitine. In five separate muscle samples from the patient the mean carnitine level was less than 20 percent of that observed in 42 controls. Carnitine palmityl transferase and palmityl thiokinase levels in the patient's muscles were not depressed. The present case represents the first recognized instance of carnitine deficiency in human skeletal muscle.

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supporting

confidence: 84%

Carnitine Deficiency of Human Skeletal Muscle with Associated Lipid Storage Myopathy: A New Syndrome

Engel

Angelini

1973

Science

478

115

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“…There have been several reports concern ing phospholipid synthesis in the choline -deficient animals (24)(25)(26)(27)(28)(29). DiLuzio and Zil versmit reported impairment of the synthesis of choline-containing phospholipids in liver slices of choline-deficient dog and reactivation of it by choline added in vitro over the value of the controls (24).…”

Section: Discussionmentioning

confidence: 99%

Studies on the Phospholipid Metabolism in Choline-Deficient Guinea Pigs

1970

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“…Administration of pivalic acid to pregnant and lactating rats induced carnitine depletion in the dam's milk and produced carnitine deficiency in pup tissue (Davis, 1995). Other animal models of carnitine-deprived newborn rats were developed using general nutrition deficit such as feeding with choline-deficient (Corredior et al, 1967) or low protein diets (Ahern and Mitchell, 1989) or artificially rearing methods (Flores et al, 1996). This last model used carnitine-deprived artificial milk administered via gastrostomy.…”

Section: Introductionmentioning

confidence: 99%