Carnitine and acetyl-carnitine, natural substances endowed with interesting pharmacological properties.

Fanelli, O

doi:10.1016/0024-3205(78)90371-5

Cited by 12 publications

(2 citation statements)

References 24 publications

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“…The heart of male rabbits weighing 1.6-1.8 kg was isolated and perfused according to Langendorffl 1895] as described in a previous paper [Fanelli, 1978). The composition of Ringer's solution was 154mmol/l NaCI.…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand exogenous carnitine affords sig nificant protection against heart damage due to diphtheria toxin in guinea pigs [Chatloner et al, 1971], to electrically induced atrial fibrillation in cats [Di Palma et al, 1975] and to induced myocardial ischemia in dogs [Schwartz et al, 1973;Vick and De Felice, 1974;Foils e\ al., 1978;Riemersma andOli ver, 1976: Vick et al. 1976], Recently, it was found that exogenous carnitine exerts a res toring effect on the isolated perfused rabbit heart depressed by prolonged anoxia [Fanelli. 1978], Other investigators confirmed these data on the ischemic swine heart [Liedke and Nellis.…”

Section: Introductionmentioning

confidence: 99%

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Carnitine Optical Isomers’ Action on the Epinephrine Stress Induced in the Isolated Perfused Rabbit Heart

Fanelli¹,

Tenuta²

1981

Pharmacology

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A cardiac stress was performed in the isolated perfused rabbit heart by means of four injections of 0.5 µg epinephrine in the coronary vessels. The endogenous (–)carnitine/acetyl(–)carnitine ratio was also determined. The two exogenous optical isomers of carnitine possess a different pharmacological behavior on the epinephrine-induced stress. Exogenous (–)carnitine reduces the epinephrine stimulating effect whereas exogenous (+)carnitine increases it, including coronary flow. Furthermore, the endogenous (–)carnitine/acetyl(–)carnitine ratio decreases significantly by ssthe stress. Exogenous (–)carnitine restores this ratio to the normal value, whereas exogenous (+)carnitine does not. It is concluded that carnitine might represent an important natural way for organism safeguard in the epinephrine stress as occurs in various emotional states. In this respect the importance of exogenous (–)carnitine as a therapeutic means remains to be investigated

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Carnitine Optical Isomers’ Action on the Epinephrine Stress Induced in the Isolated Perfused Rabbit Heart

Fanelli¹,

Tenuta²

1981

Pharmacology

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Cholinesterase‐catalyzed resolution of D,L‐carnitine

Dropsy

Klibanov

1984

Biotech & Bioengineering

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An enzymatic method for the preparative resolution of racemic carnitine (whose L-isomer and its acyl-derivatives have numerous therapeutical applications) has been developed. It is based on our finding that electriceel acetylcholinesterase hydrolyzes the D- but not the L-isomer of acetylcarnitine. (Another cholinesterase tested, horse serum butyrylcholinesterase, is also stereospecific and hydrolyzes only the L-isomer of butyrylcarnitine.) Acetylcholinesterase, covalently attached to alumina, was employed for the resolution of D,L-carnitine; the latter was first chemically acetylated, then stereoselectively hydrolyzed with the immobilized enzyme, and finally the acetyl-L-carnitine and D-carnitine produced were separated by ion-exchange chromatography. Gram quantities of D,L-carnitine were thereby resolved.

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A Potentiometric approach to the study of the antagonism between acetazolamide and I‐carnitine congeners on carbonic anhydrase activity

Botrê

Botrè

1991

Electroanalysis

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The in vitro interactions among carbonic anhydrase (CA), acetazolamide (ACTZ), and some short chain acylcarnitines (l- and d-isomers) were studied by means of a recently developed potentiometric method of analysis, based on a pCO2 sensor. The l- and d-isomers of carnitine (C), acetylcarnitine (AC), propionylcarnitine (PC), and isobutyrrylcarnitine (iBC) were found not to affect CA catalytic activity in the absence of other compounds. Upon testing in the presence of ACTZ, the l-isomers of the carnitine congeners were shown to antagonize the chemical inhibition of carbonic anhydrase II from bovine erythrocytes, whereas in this case the d-isomers did not show any effect. The results obtained in these experiments, carried out at 25 and at 37-degrees-C, confirm the high reliability of this new approach and highlight the positive effect of l-carnitine congeners on CA catalytic activity. The potentiometric method should be suitable for monitoring the interaction of other enzymes and CA

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Carnitine and acetyl-carnitine, natural substances endowed with interesting pharmacological properties.

Cited by 12 publications

References 24 publications

Carnitine Optical Isomers’ Action on the Epinephrine Stress Induced in the Isolated Perfused Rabbit Heart

Carnitine Optical Isomers’ Action on the Epinephrine Stress Induced in the Isolated Perfused Rabbit Heart

Cholinesterase‐catalyzed resolution of D,L‐carnitine

A Potentiometric approach to the study of the antagonism between acetazolamide and I‐carnitine congeners on carbonic anhydrase activity

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Carnitine and acetyl-carnitine, natural substances endowed with interesting pharmacological properties.

Cited by 12 publications

References 24 publications

Carnitine Optical Isomers&rsquo; Action on the Epinephrine Stress Induced in the Isolated Perfused Rabbit Heart

Carnitine Optical Isomers&rsquo; Action on the Epinephrine Stress Induced in the Isolated Perfused Rabbit Heart

Cholinesterase‐catalyzed resolution of D,L‐carnitine

A Potentiometric approach to the study of the antagonism between acetazolamide and I‐carnitine congeners on carbonic anhydrase activity

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Product

Resources

About

Carnitine Optical Isomers’ Action on the Epinephrine Stress Induced in the Isolated Perfused Rabbit Heart

Carnitine Optical Isomers’ Action on the Epinephrine Stress Induced in the Isolated Perfused Rabbit Heart