Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation

Hattori, Shinji; Yamane, Yukou; Shimomura, Ryoichi; Uchida, Yuki; Toyota, Nobuhiko; Miura, Yoshio; Shiota, Setsujyo; Tajima, Yoshitsugu

doi:10.1186/s40792-018-0438-z

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…The thyroid gland shows multiple and bilateral proliferative follicular lesions, including Hürthle cell nodules. There is multinodular hyperplasia, sometimes with peculiar microscopic “follicular adenomatosis” along with multiple follicular adenomas in up to 75% of CNC patients [ 241 , 245 , 251 ]. Follicular adenomatosis [ 244 ] is characterized by the presence of multiple encapsulated and uncapsulated follicular thyroid nodules distributed throughout the gland in a manner equivalent to the so-called microadenomas that appear in PHTS (see above).…”

Section: Syndromic Familial Non-medullary Thyroid Carcinoma (Sfnmtc)mentioning

confidence: 99%

Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates

et al. 2021

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Cancer derived from thyroid follicular epithelial cells is common; it represents the most common endocrine malignancy. The molecular features of sporadic tumors have been clarified in the past decade. However the incidence of familial disease has not been emphasized and is often overlooked in routine practice. A careful clinical documentation of family history or familial syndromes that can be associated with thyroid disease can help identify germline susceptibility-driven thyroid neoplasia. In this review, we summarize a large body of information about both syndromic and non-syndromic familial thyroid carcinomas. A significant number of patients with inherited non-medullary thyroid carcinomas manifest disease that appears to be sporadic disease even in some syndromic cases. The cytomorphology of the tumor(s), molecular immunohistochemistry, the findings in the non-tumorous thyroid parenchyma and other associated lesions may provide insight into the underlying syndromic disorder. However, the increasing evidence of familial predisposition to non-syndromic thyroid cancers is raising questions about the importance of genetics and epigenetics. What appears to be “sporadic” is becoming less often truly so and more often an opportunity to identify and understand novel genetic variants that underlie tumorigenesis. Pathologists must be aware of the unusual morphologic features that should prompt germline screening. Therefore, recognition of harbingers of specific germline susceptibility syndromes can assist in providing information to facilitate early detection to prevent aggressive disease.

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Section: Syndromic Familial Non-medullary Thyroid Carcinoma (Sfnmtc)mentioning

confidence: 99%

Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates

et al. 2021

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“…In isolated cardiac myxomas, surgical treatment is typically curative. However, patients with CNC showed higher recurrence rates (10‐21% vs 4‐7% for isolated myxomas) . Reasons for relapses include inadequate resections, intraoperative implantation of parts of the tumor, and multi‐centric tumor location .…”

Section: Discussionmentioning

confidence: 99%

“…However, patients with CNC showed higher recurrence rates (10-21% vs 4-7% for isolated myxomas). [30][31][32][33][34][35][36][37][38] Reasons for relapses include inadequate resections, intraoperative implantation of parts of the tumor, and multi-centric tumor location. 29,30,37 In our study, the rate of multiple cardiac myxomas in CNC was significantly higher than that of isolated cardiac myxomas (30% vs 11.17%, P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Clinical features and surgical results of cardiac myxoma in Carney complex

et al. 2019

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Background We sought to analyze clinical features and surgical results of 10 cases of cardiac myxomas in Carney complex (CNC). Methods Between January 2003 and December 2013, 10 patients with cardiac myxomas in CNC underwent surgical resection. Associated cardiac lesions included moderate and severe mitral regurgitation in two cases, and moderate tricuspid regurgitation in one case. Age, gender, the incidence of arterial embolism, the rate of multiple cardiac myxomas, and the recurrence rate after resections of cardiac myxoma were compared between isolated cardiac myxomas and cardiac myxomas in CNC. Results The incidence of cardiac myxoma in CNC was 1.74% (10/574). There were no deaths following surgery. There was one late death due to cerebral embolism 40 months following a reoperation (10%). A significant difference was found in the age, the incidence of arterial embolism, the rate of multiple cardiac myxomas, and the recurrence rate after resection of cardiac myxoma between cardiac myxoma in CNC and isolated cardiac myxoma (P < 0.05). There was no significant difference in gender between cardiac myxoma in CNC and isolated cardiac myxoma (P > 0.05). Conclusions Complex myxomas in CNS present at an earlier age, are more prevalent in women than in men, are more often multicentric, with a higher rate of arterial embolism and a high recurrence rate after resection. Close follow‐up for cardiac myxoma in CNC after surgery is necessary due to the high recurrence rate.

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“…According to the statistics of cancer center, the inci-dence of thyroid cancer is increasing rapidly worldwide, while it continues to increase every year in China [5]. The clinical symptoms of the patients in the early stage of the disease are inconspicuous [6]. With the aggravation of the disease and the growth of the tumor, thyroid cancer patients may develop enlarged or nodular thyroid, which is hard and painful.…”

Section: Introductionmentioning

confidence: 99%

Aberrantly Expressed lncRNA LINC00847 May Serve as a Promising Prognostic Factor for Thyroid Cancer

Hei

et al. 2023

Horm Metab Res

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Thyroid cancer is a tumor that occurs in the head and neck, which originates from the thyroid follicular epithelial cells. The current research is discussed and elaborated from the perspective of molecular prognostic biomarkers to gain a deeper understanding of the molecular mechanism of thyroid cancer and to provide more effective treatment and prognostic methods for patients. Thyroid cancer patients were explored from histological, cellular and clinical levels. Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of LINC00847 and miR-146b-5p in the tissues and cells of the subjects. Cell growth and thyroid cancer progression were determined by the cell counting kit-8 (CCK-8) and transwell assays. The LINC00847 sponge miR-146b-5p was assessed by bioinformatics tools and luciferase reporter assay, and the Kaplan–Meier method and multivariate Cox regression analysis suggested the prognostic value of high expression of LINC00847. In thyroid cancer tissues and cells, the expression of LINC00847 was decreased. Overexpression of LINC00847 remarkably inhibited the proliferation level, migration ability and invasion ability of thyroid cancer cells. Besides, miR-146b-5p was upregulated in thyroid cancer tissues and cells. It was confirmed that LINC00847 targeting miR-146b-5p had a regulatory effect on the progression of thyroid cancer, and LINC00847 was negatively correlated with miR-146b-5p. LINC00847 may be considered a meaningful prognostic marker to influence tumor growth through sponge miR-146b-5p, which provides a new basis for the prognosis and treatment of thyroid cancer.

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Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation

Cited by 6 publications

References 11 publications

Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates

Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates

Clinical features and surgical results of cardiac myxoma in Carney complex

Aberrantly Expressed lncRNA LINC00847 May Serve as a Promising Prognostic Factor for Thyroid Cancer

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