Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors

Abstract

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Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Aspergillus sp. YJ191021

“…The absolute configurations of C-3, C-11, C-17, and C-21 in 2 were assigned as 3R, 11R, 17R, and 21S based on the negative Cotton effect at 225 nm in ECD spectra ( Figure 4B and Figure S17) and calculated ECD spectra ( Figure 4B). 5.75)/H-23 (δH 0.52) indicated that these protons located on the β-orientation of the cyclopentane ring. Besides, the ROESY correlations from H-21 (δH 2.68) to H-4 (δH 6.89) indicated that the cyclopentane ring was orthogonal to the plane of the indoxyl ring.…”

“…Endophytic fungi are prolific microbial resources for the production ability of many biologically active secondary metabolites, which can help the host to resist pathogenic microorganisms [2]. Various endophytic fungi have drawn substantial attention due to their potential to produce chemically diverse and biologically active secondary metabolites with anti-cancer, anti-microbial, anti-viral, and insecticidal activities [3][4][5][6]. In our continuous searching for novel bioactive secondary metabolites from marine endophytic fungi [7][8][9], the Aspergillus sp.…”

“…In this study, we described the isolation and structure identification of six new prenylated indole diketopiperazine alkaloids (1)(2)(3)(4)(5)(6), together with eight known analogues: Gartryprostatin A (7) [15], gartryprostatin B (8) [15], sclerotiamide (9) [16], notoamide H (10) [17], 6-epi-notoamide R (11) [18], notoamide R (12) [19], (-)-notoamide I (13) [20], and gartryprostatin C (14) [15] (Figure 1) from the marine-derived endophytic fungus Aspergillus sp. YJ191021.…”

RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review

“…1 ) and the lower inhibitory potential of the compounds when this subunit is oxidized at C-18. They further listed the β-OH group at C-9 in compound 15 as likely responsible for the activity of this compound on the polymerase [ 22 ]. The literature indicates that some molecules selected from the Dacrydium balansae species did not show the same potential as isolated biflavonoids (compounds 28 , 36 , 7 , 29 ), thus suggesting, through the comparison of chemical structures, the importance of the dimeric nature of biflavonoids (Fig.…”

“…f Carneic acids C (12) 19.0 RdRp-DENV b [ 22 ] Phomopsis sp . f Carneic acids D (13) 19.0 RdRp-DENV b [ 22 ] Phomopsis sp . f Carneic acids F (15) 11.8 RdRp-DENV b [ 22 ] Phomopsis sp .…”