Carmellose Mucoadhesive Oral Films Containing Vermiculite/Chlorhexidine Nanocomposites as Innovative Biomaterials for Treatment of Oral Infections

Gajdziok, Jan; Holešová, Sylva; Štembírek, Jan; Pazdziora, Erich; Landová, Hana; Doležel, Petr; Vetchý, David

doi:10.1155/2015/580146

Cited by 30 publications

(21 citation statements)

References 56 publications

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“…A miconazole mucoadhesive tablet has been reported, which had in vitro antifungal activity against many Candida species. With a once-daily application of the tablet containing 50 mg of miconazole of 50 mg, it could maintain high levels of salivary miconazole concentrations effectively treat pseudomembranous candidiasis [190]. Other nano-scaled copolymers, lipid, or chitosan-based DDS have also been investigated (Figure 6a-c).…”

Section: Dds For Oral Candidiasismentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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Section: Dds For Oral Candidiasismentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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“…Notably, a smaller proportion of the studies (19.4%) assessed the composites using in vitro models based on cytotoxicity assays, adhesion ability and cellular absorption, and also antimicrobial assessment (4,13,35,37,56,62,74).…”

Section: Clay and Polymer-based Composites Applied As Drug Carriersmentioning

confidence: 99%

“…The main drugs carried in the articles analysed were non-steroidal anti-inflammatory drugs (46.1%) (24,39,40,(66)(67)(68), antimicrobial (25.6%) (21,34,65,69,74) and chemotherapeutic agents (10.3%) (13,14). This distribution can be explained by the adverse events associated with the use of these active principles, whether due to the reduction in gastric protection resulting from prolonged use of the anti-inflammatory drugs and analgesics, or to the intrinsic toxicity of chemotherapeutic agents and some antimicrobials associated with the risk of resistance (75,76).…”

Section: Clay and Polymer-based Composites Applied As Drug Carriersmentioning

confidence: 99%

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Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Meirelles

Raffin

2017

J Pharm Pharm Sci

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-There has been a growing trend in recent years for the development of hybrid materials, called composites, based on clay and polymers, whose innovative properties render them attractive for drug release. The objective of this manuscript was to conduct a review of original articles on this topic published over the last decade and of the body of patents related to these carriers. A scientific prospection was carried out spanning the period from 2005 to 2015 on the Web of Science database. The technological prospection encompassed the United States Patent and Trademark Office, the European Patent Office, the World International Patent Office and the National Institute of Industrial Property databases, filtering patents with the code A61K. The survey revealed a rise in the number of publications over the past decade, confirming the potential of these hybrids for use in pharmaceutical technology. Through interaction between polymer and clay, the mechanical and thermal properties of composites are enhanced, promoting stable, controlled drugs release in biological media. The most cited clays analyzed in the articles was montmorillonite, owing to its high surface area and capacity for ion exchange. The polymeric part is commonly obtained by copolymerization, particularly using acrylate derivatives. The hybrid materials are obtained mainly in particulate form on a nanometric scale, attaining a modified release profile often sensitive to stimuli in the media. A low number of patents related to the topic were found. The World International Patent Office had the highest number of lodged patents, while Japan was the country which published the most patents. A need to broaden the application of this technology to include more therapeutic classes was identified. Moreover, the absence of regulation of nanomaterials might explain the disparity between scientific and technological output.

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“…Usually, the films consist of two layers, one of which is adhesive and the second is a covering (backing) layer protecting the first one against moisture and providing the film with mechanical durability . The adhesive layer may also contain a sorbent carrying an active agent , or, as in this study, the film can be used as a patch covering a lesion on which an active agent was applied.…”

Section: Introductionmentioning

confidence: 99%

Buccal films as a dressing for the treatment of aphthous lesions

Daněk

Gajdziok

Doležel

et al. 2017

J Oral Pathology Medicine

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The application of buccal films covering aphthous lesions during the treatment significantly increased the rate of healing when compared with the standard methods of treatment. While the pain improvement was statistically significant as soon as Day 3 in the experimental group, it was only apparent on Day 5 in the control group, and the number of successfully treated patients (pain perception improving to visual analogue scale 2 or less) was at all time points higher in the experimental group than in the control group. The results imply that the use of buccal films for treatment of aphthous lesions is very promising and can lead to a significant reduction in the duration of patients' discomfort.

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Carmellose Mucoadhesive Oral Films Containing Vermiculite/Chlorhexidine Nanocomposites as Innovative Biomaterials for Treatment of Oral Infections

Cited by 30 publications

References 56 publications

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Buccal films as a dressing for the treatment of aphthous lesions

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