Cariological Studies of Individuals with Long-Term Sorbitol Consumption (Short Communication)

Teat tablet with sodium ibuprofen: the effect of sorbitol on therapeutic agent pharmaceutical availability and on physicochemical parameters of a drug form

“…Obtaining adequate thickness and bulk density of the tablet mass reflected in uniform and homogenous pouring of the mixture into the matrice, enabled getting tablets of demanded mass (m t [g]) resulting from the prescription and density (appropriate tablet size in relation to its mass) ( Table 2). This was visible to the "naked eye" because the effect of flowing in a beaker during release test was not observed in all the tested tablets of all batches [23][24][25][26][27].…”

“…The problem which could have resulted from sorbitol high hygroscopicity was solved by increasing the amount of lubricating agent -magnesium stearate -from 0.5% to 1.0%. It is small percentage share in total tablet mass and it does not affect pharmaceutical availability of the therapeutic agent [23][24][25][26][27].…”

“…In the tests the declared dose of therapeutic agent is released by two methods. In the case of batch III tablets of low content of adjuvant bioadhesive substances the tablet mass was not observed to remain inside the teat in the course of the experiment [23][24][25][26][27]30,31].…”

“…Sorbitol is also widely used in pharmaceutical technology in the production of tablets, capsules, syrups, suspensions, dermatological and dental preparations. Due to high level of sweetness (0,5 -0,7 in relation to saccharose) and to the production of heat which results in a cooling effect during tablet sucking, it is an adjuvant substance in the production of sucking tablets [23][24][25][26][27].…”

Çeşitli sakızların ağız ve diş sağlığı üzerine etkilerinin değerlendirilmesi

“…Sorbitolün oral mikroorganizmalar tarafından metabolize edilme süresi sukroz ve fruktoza oranla çok uzun olduğundan plak pH' si düşmez bu nedenle sorbitol ile tatlandırılan ürünlerin çürük oluşturma riski bulunmaz. 17,18 Sorbitol içeren sakızlar tükürük akışını, plak pH'sini ve tamponlama kapasitesini uyararak, özellikle interproksimal alanlarda plak pH'sini hızla nötralize eder. 6,10,19 Tatlı yenilmesinin ardından 10 dakika süreyle sorbitollü sakız çiğ-nenmesinin interproksimal plak pH'sini hızla yükselttiği gösterilmiştir.…”