Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents

Meyer, Frederic; Enax, Joachim; Epple, Matthias; Amaechi, Bennett T.; Simader, Barbara

doi:10.3390/dj9080088

Cited by 29 publications

(32 citation statements)

References 111 publications

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“…From a chemical point of view, there is no principal difference between an attack by acids from food (erosion) and by acids produced by bacteria (caries). However, the duration of these demineralization processes is usually different (erosion: short time scale, due to the presence of acidic beverages, food, or gastric juice [ 20 ]; caries: long time scale [ 24 , 25 ], e.g., in biofilms [ 26 , 27 ]).…”

Section: Protection Of Teeth Against Caries and Erosion By Fluoride-containing Agentsmentioning

confidence: 99%

Prevention of Caries and Dental Erosion by Fluorides—A Critical Discussion Based on Physico-Chemical Data and Principles

2022

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Dental erosion is a common problem in dentistry. It is defined as the loss of tooth mineral by the attack of acids that do not result from caries. From a physico-chemical point of view, the nature of the corroding acids only plays a minor role. A protective effect of fluorides, to prevent caries and dental erosion, is frequently claimed in the literature. The proposed modes of action of fluorides include, for example, the formation of an acid-resistant fluoride-rich surface layer and a fluoride-induced surface hardening of the tooth surface. We performed a comprehensive literature study on the available data on the interaction between fluoride and tooth surfaces (e.g., by toothpastes or mouthwashes). These data are discussed in the light of general chemical considerations on fluoride incorporation and the acid solubility of teeth. The analytical techniques available to address this question are presented and discussed with respect to their capabilities. In summary, the amount of fluoride that is incorporated into teeth is very low (a few µg mm−2), and is unlikely to protect a tooth against an attack by acids, be it from acidic agents (erosion) or from acid-producing cariogenic bacteria.

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Section: Protection Of Teeth Against Caries and Erosion By Fluoride-containing Agentsmentioning

confidence: 99%

Prevention of Caries and Dental Erosion by Fluorides—A Critical Discussion Based on Physico-Chemical Data and Principles

2022

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“…Children's oral cavity occurrence is greatly affected by a frequent tooth-brushing habit and a healthy diet, which prevents the presence of caries biofilm which is the principal factor of developing caries in the presence of fermentable sugars and carbohydrates and might result in teeth demineralization. In some cases, especially in those with diabetes mellitus, the total amount of sugar is reduced but dental caries exists as a result of the presence of cariogenic biofilm [16].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Parental Education and Socioeconomic Status on Dental Caries among Saudi Children

Ellakany

Madi²,

Fouda³

et al. 2021

IJERPH

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Parental attitudes toward the importance of oral hygiene have an impact on the formation of their children’s oral habits and the prevalence of oral diseases. Our aim was to assess the association between parents’ education and socioeconomic status and their children’s oral health. A cross-sectional study was conducted between the years of 2018 and 2020 in the eastern province of Saudi Arabia among primary school children. Two pre-calibrated dentists performed the clinical examination of the children, and a self-administered validated questionnaire was obtained from their parents. Clinical examination was performed on 589 children with an age range of 3 to 14 years, where 47% were males and 53% were females, 70% with dental caries. Both parents with higher education and a high monthly income were significantly associated with lower prevalence of decayed teeth in their children, respectively. Mother’s education, age, gender and application of sealant were found significantly associated with the high prevalence of caries. High prevalence of tooth decay was reported among school children in the eastern province of Saudi Arabia. A high educational level of parents and high income were correlated with a lower prevalence of decayed teeth, similarly to the situation in the case of presence of medical insurance.

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“…ferent organomineral complexes in the prophylactic agents whose molecular composition is similar to that of the biofilm organomineral complex. From this, we can draw a preliminary conclusion that the use of prophylactics at the appropriate stage of the experiment can affect the molecular composition of biofilms [9,37], which in turn is reflected in the spectroscopic characteristics. It is clearly observed that the effect of the prophylactic agent depending on the cariogenic conditions is reflected in the position and shape of the vibrational mode of Amide I (Figure 4).…”

Section: Fingerprint Regionmentioning

confidence: 97%

Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study

et al. 2022

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(1) Objectives: This study is the first one to investigate the molecular composition of the dental biofilm during the exogenous and endogenous prophylaxis stages (use of dentifrice/drug) of individuals with different cariogenic conditions using molecular spectroscopy methods. (2) Materials and Methods: The study involved 100 participants (50 males and 50 females), aged 18–25 years with different caries conditions. Biofilm samples were collected from the teeth surface of all participants. The molecular composition of biofilms was investigated using synchrotron infrared microspectroscopy. Changes in the molecular composition were studied through calculation and analysis of ratios between organic and mineral components of biofilm samples. (3) Results: Based on the data obtained by synchrotron FTIR, calculations of organic and mineral component ratios, and statistical analysis of the data, we were able to assess changes occurring in the molecular composition of the dental biofilm. Variations in the phosphate/protein/lipid, phosphate/mineral, and phospholipid/lipid ratios and the presence of statistically significant intra- and inter-group differences in these ratios indicate that the mechanisms of ion adsorption, compounds and complexes arriving from oral fluid into dental biofilm during exo/endogenous prophylaxis, differ for patients in norm and caries development. (4) Conclusions: The conformational environment and charge interaction in the microbiota and the electrostatic state of the biofilm protein network in patients with different cariogenic conditions play an important role. (5) Clinical Significance: Understanding the changes that occur in the molecular composition of the dental biofilm in different oral homeostasis conditions will enable successful transition to a personalised approach in dentistry and high-tech healthcare.

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Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents

Cited by 29 publications

References 111 publications

Prevention of Caries and Dental Erosion by Fluorides—A Critical Discussion Based on Physico-Chemical Data and Principles

Prevention of Caries and Dental Erosion by Fluorides—A Critical Discussion Based on Physico-Chemical Data and Principles

The Effect of Parental Education and Socioeconomic Status on Dental Caries among Saudi Children

Effect of Exo/Endogenous Prophylaxis Dentifrice/Drug and Cariogenic Conditions of Patient on Molecular Property of Dental Biofilm: Synchrotron FTIR Spectroscopic Study

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