Terminal delirium is a common symptom at the end of life that may increase family and caregiver stress and impact the bereavement process for loved ones who do not understand the dying trajectory. A retrospective, medical record review was used to explore the onset of delirium, the trajectory of terminal delirium symptoms, and time of death within the last 7 days of life among terminally ill patients; to better understand the frequency of end-of-life symptoms; and to increase knowledge about the death event in this population. A 10-item Delirium Rating Scale was used to validate the diagnosis of delirium reported symptoms noted in the clinical records of a convenience sample (n = 73) of deceased patients who had been admitted to a large Midwestern hospice. The onset of terminal delirium to time of death on average was 3.5 days. Using Delirium Rating Scale scores, by day 6 the majority of patients were experiencing terminal delirium. Commonly occurring symptoms were somnolence followed by communication difficulty, memory disturbance, thinking difficulty, and disorientation. This dying trajectory may be useful to more closely predict the time of death in patients with terminal illness.Terminal delirium is a syndrome occurring most commonly within the final 24 to 48 hours of life in approximately 88% of patients with advanced cancer. 1 Four categories of terminal delirium have been identified: hyperactive (symptoms include agitation, psychosis, and emotional lability), hypoactive (symptoms include sluggishness, lethargy, confusion, and an absence of disruptive or bizarre behavior), mixed (symptoms include both hyperactive and hypoactive), and unclassified (has no motor component nor meets the criteria for hyperactive-hypoactive). 2 The causes of terminal delirium are multifactorial, including precipitating and predisposing factors (infections, nutritional deficiencies, direct central nervous system disorders, organ failure, electrolyte imbalances, anemias, and medications) and the vulnerability of the person. 3