Caries Preventive and Antibacterial Effects of Two Natural Mouthwashes vs Chlorhexidine in High Caries-risk Patients: A Randomized Clinical Trial

Kamal, Dina; Hassanein, Hassan; Akah, Mai; Abdelkawy, Mostafa A.; Hamza, Heba

doi:10.5005/jp-journals-10024-2986

Cited by 8 publications

(19 citation statements)

References 47 publications

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“…Reading the full text occasioned the omission of 72 additional investigations because they did not meet some selection criteria. Finally, five RCTs 13–17 were included in this systematic scoping review (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…These investigations assessed 442 participants with a minimum sample of 16 13 patients and a maximum of 159 16 . The follow‐up of the RCTs was between 10 days 13 and 12 months 14,16,17 …”

Section: Resultsmentioning

confidence: 99%

“…One RCT utilized a quantitative analysis with ImageJ (National Institutes of Health) to measure the quantity of surface colonization by microorganisms after converting all images to RGB (red, green, and blue) stack and setting the equivalent colour threshold 13 . Kamal et al 14 calculated the minimum inhibitory concentration (MIC) in agreement with the National Committee for Clinical Laboratory Standards recommendations. On the other hand, prototype colonies were subcultured from the medium containing triclosan on non‐selective media; subsequently, pure cultures of the triclosan‐resistant strains were then differentiated 16 .…”

Section: Resultsmentioning

confidence: 99%

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Bacterial resistance to antiseptics used in dentistry: A systematic scoping review of randomized clinical trials

Medina

Bedoya-García

2022

Int J Dental Hygiene

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The menace of antibiotic resistance has had robust relevance recently. This concern has led to the creation of public policies and alternative antimicrobial management. 1 Contrariwise, less consideration has been assumed to the directly interconnected trouble of resistance regarding antiseptics. 1,2 This is noteworthy because microbial resistance to antiseptics such as benzalkonium chloride and biocides (triclosan, chlorhexidine, and cetylpyridinium chloride), including the induction of cross-resistance between them and some antibiotics, has long been recognized in the medical management of different diseases. 3,4 These antiseptics have also been widely used in dentistry as oral rinses and gels, including oral care formulations. The use of antiseptics has also been extended to improve the oral hygiene conditions of hospitalized patients. 5,6 Thus, present protocols of prevention in dentistry are pointed at decreasing dental biofilm in an attempt to diminish the occurrence of periodontal diseases and caries. 7 On the

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Section: Resultsmentioning

confidence: 99%

“…These investigations assessed 442 participants with a minimum sample of 16 13 patients and a maximum of 159 16 . The follow‐up of the RCTs was between 10 days 13 and 12 months 14,16,17 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Bacterial resistance to antiseptics used in dentistry: A systematic scoping review of randomized clinical trials

Medina

Bedoya-García

2022

Int J Dental Hygiene

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“…The practice of recommending use of antimicrobial mouthwash and probiotics were included in the questionnaire, though research on their efficacy in caries management is ongoing and the extent of current level of use is unknown. 23 - 25 …”

Section: Methodsmentioning

confidence: 99%

Dental Practitioners’ Knowledge, Attitude, and Practice in Caries Risk Assessment and Management: A Cross-sectional Survey in Kampala Metropolitan, Uganda

Ndagire¹,

Muwazi²,

Nabaggala³

et al. 2022

The Journal of Contemporary Dental Practice

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Aim: The objective of this study was to determine the knowledge, attitude, and practices regarding caries risk assessment (CRA) and management among dental practitioners in Kampala Metropolitan, Uganda. Materials and methods: This cross-sectional study was conducted among 270 dental practitioners in Kampala Metropolitan, Uganda, in May 2021. The participants were dental surgeons and public health dental officers. A self-administered structured questionnaire was used to collect data. The questionnaire included items about participants’ sociodemographic characteristics, knowledge, attitude, and practices in CRA and management. Attitude and practices were rated using different Likert scales. Descriptive statistics, Chi-square/Fisher’s exact and one-way analysis of variance (ANOVA) with post-hoc Bonferroni tests were used to analyze the data. The significance level was set at p <0.05. Results: About 60.7% of the participants were public health dental officers with a median age of 30 years (interquartile range [IQR], 27–60). Overall, the participants were familiar with the current concepts regarding CRA and management. More than 70% of the participants correctly identified risk factors and indicators of dental caries. Most participants (98.5%) had a positive attitude toward performing CRA. However, their practices regarding caries management were inadequate as majority (>75%) of participants reported that they never or occasionally recommended evidence-based products like topical fluoride, probiotics, or xylitol products in the prevention and management of dental caries. Dental surgeons had significantly better knowledge and practices than public health dental officers ( p <0.05). Conclusion: In the present study, the participants were familiar with the current concepts about CRA and had a positive attitude toward CRA. However, their practices regarding caries prevention and management were inadequate. Clinical significance: The study provided baseline data about knowledge, attitude, and practices regarding CRA and caries management among dental practitioners in Uganda. It is recommended to design training courses in evidence-based protocols in the prevention and management of dental caries for dental practitioners in Uganda.

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“…The mouth rinsing custom has been a part of human culture for more than 200 decades. Kamal et al reported that natural mouthwashes could serve as substitutes to chemical agents such as chlorhexidine, providing effective caries control and safe long-term use [14]. Mouth rinses containing dextranase were superior to 0.12% chlorhexidine mouthwash in preventing plaque accumulation caused by Lipomyces starkeyi KSM 22 and Catenovulum agarivorans MNH15 in human experimental gingivitis [15,16].…”

Section: Introductionmentioning

confidence: 99%

Effect of Dextranase and Dextranase-and-Nisin-Containing Mouthwashes on Oral Microbial Community of Healthy Adults—A Pilot Study

et al. 2022

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This study analyzed the alteration of oral microbial composition in healthy subjects after using dextranase-containing mouthwash (DMW; Mouthwash formulation I) and dextranase-and-nisin-containing mouthwash (DNMW; Mouthwash formulation II). Eighteen participants were recruited and were randomly allocated to two groups: G1 (DMW user; n = 8) and G2 (DNMW user; n = 10). The subjects were instructed to use the provided mouthwash regularly twice a day for 30 days. The bleeding on probing (BOP), plaque index (PI), probing depth (PBD), and gingival index (GI) were analyzed, and saliva samples were collected before (day 0) and after (day 30) the use of mouthwashes. The saliva metagenomic DNA was extracted and sequenced (next-generation sequencing, Miseq paired-end Illumina 2 × 250 bp platform). The oral microbial community in the pre-and post-treated samples were annotated using QIIME 2™. The results showed the PI and PBD values were significantly reduced in G2 samples. The BOP and GI values of both groups were not significantly altered. The post-treated samples of both groups yielded a reduced amount of microbial DNA. The computed phylogenetic diversity, species richness, and evenness were reduced significantly in the post-treated samples of G2 compared to the post-treated G1 samples. The mouthwash formulations also supported some pathogens’ growth, which indicated that formulations required further improvement. The study needs further experiments to conclude the results. The study suggested that the improved DNMW could be an adjuvant product to improve oral hygiene.

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Caries Preventive and Antibacterial Effects of Two Natural Mouthwashes vs Chlorhexidine in High Caries-risk Patients: A Randomized Clinical Trial

Cited by 8 publications

References 47 publications

Bacterial resistance to antiseptics used in dentistry: A systematic scoping review of randomized clinical trials

Bacterial resistance to antiseptics used in dentistry: A systematic scoping review of randomized clinical trials

Dental Practitioners’ Knowledge, Attitude, and Practice in Caries Risk Assessment and Management: A Cross-sectional Survey in Kampala Metropolitan, Uganda

Effect of Dextranase and Dextranase-and-Nisin-Containing Mouthwashes on Oral Microbial Community of Healthy Adults—A Pilot Study

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