Caries Experience and the Mineral Content of Plaque in a Primitive Population in New Guinea

Investigations into the role of strontium (Sr) in caries prevention have attracted great interest in the research community in the past, with its peak in the 1970-and 80ies. To this date, no clear indication of the relative importance of Sr in caries prevention has been provided. A vast number of animal caries, epidemiological and mechanistic studies have been conducted. Albeit Although a great level ofthere is much discrepancyexists in the literature, the majority of studies suggest that Sr exhibits some cariostatic properties and, predominantly in the presence of fluoride (F). An optimum Sr concentration of 5 to 10 ppm in drinking water has been proposed as a direct result of several epidemiological caries studies. Despite these results, no direct link can be established between Sr and caries prevention as, to date, no relevant, randomized control trials have been reported. The extrapolation of potential cariostatic properties of Sr from epidemiological studies is difficult due to the co-presence of several other trace elements in the water of the study areas, with many of these elements being attributed cariostatic properties in their own right.

Section: Sr In the Oral Fluids -Plaque And Salivasupporting

confidence: 68%

“…Schamschula et al [1977b] reported a negative correlation between [Sr] and DMFT (r = -0.15) in a primitive population in Papua New Guinea (n = 301; 12 -24 years of age), which, however, was weaker than those correlations for [Ca] and [F].…”

Section: Epidemiological Caries Studiesmentioning

confidence: 89%

Strontium and Caries: A Long and Complicated Relationship

Lippert

Hara²

2012

“…Moreover, 5.0 mM Cu-SO4 also reduced caries areas more than did 20.0 mM NaF when applied topically. On the other hand, there are epidemiologi cal data indicating some correlation be tween high dietary intake of elementary copper in man and high caries prevalence [Barmes, 1969;Ludwig et al, 1970;Schamschula et al, 1978]. Copper concen tration in food or drinking water is gene rally negligible and not readily available as ions compared to the therapeutic con centrations used in the present study.…”

Section: Discussionmentioning

confidence: 67%

Effect of Copper Applied Topically or in Drinking Water on Experimental Caries in Rats

Afseth¹,

Amsbaugh²,

Monell-Torrens³

et al. 1984

The effect of copper sulfate applied topically or in drinking water on dental caries was investigated in rats. Two daily topical applications of 0.2 ml of 5.0 mM Cu²⁺ as CuSO₄ ad libitum or 1.0 mM CuSO₄ in the drinking water reduced the caries scores significantly on all tooth surfaces. The number of Streptococcus mutans colonising tooth surfaces was also significantly reduced by 1.0 mM Cu²⁺ in drinking water.

“…Epidemiological evidence for an in verse relationship between plaque miner als and caries [Ashley and Wilson, 1977;/4gu.«et al, 1976;Schamschula et al, 1978] has recently been supported by experi mental evidence [Pearce, 1982]. Calcium, phosphate and fluoride deposited in plaque from this mouth rinse would thus be expected to have significant beneficial effects.…”

Section: Discussionmentioning

confidence: 77%

Therapeutic Modifications to the Mineral Ion Composition of Dental Plaque

Pearce¹

1984

A mouth rinse containing calcium, phosphate, fluoride, urea and monofluorophosphate was used 12 times over 3 days by 15 young adults. The concentration of acid-extractable fluoride in 4-day-old plaque rose from 8.4 to 560 ng/mg dry weight. Plaque calcium increased from 4.1 to 42.5 μg/mg and phosphate from 3.9 to 22.7 μg/ mg. The ions are fixed in a form insoluble in saliva, probably as fluorhydroxyapatite, and thus are likely to have an extended caries-protective effect.