Caries and micronutrient intake among urban South African children: a cohort study

MacKeown, Jennifer M; Cleaton‐Jones, Peter; Fatti, Paul

doi:10.1034/j.1600-0528.2003.00042.x

Cited by 18 publications

(19 citation statements)

References 36 publications

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“…Findings from previous studies are contradictory, with reports of no relationship [10], a weak relationship [9] and even a direct relationship between micronutrient deficiencies and dental caries [7,11,13]. However, studies that have related malnutrition or micronutrient deficiencies to dental caries in the primary dentition offer indirect evidence of this association [19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…The clarification of this issue is important because it is the basis for the planning of prevention strategies aimed at adverse health conditions in childhood. In one of the few longitudinal studies with a reasonable sample size, the authors investigated 21 micronutrients in 259 South African children at 12 months of age and reported an effect on oral health at five years of age [9]. However, the authors found a weak, isolated association without clinical importance between magnesium intake and dental caries.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, divergent opinions are found on the association between micronutrient intake and early childhood caries. While some studies have found no such association, others suggest that micronutrients have a cariostatic effect and others suggest a cariogenic effect [6][7][8][9][10][11][12][13]. However, the majority of these findings come from animal studies or investigations involving human subjects using a cross-sectional design.…”

Section: Introductionmentioning

confidence: 99%

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No Impact of Lower Intake of Micronutrients on Severe Early Childhood Caries: Findings from a Prospective Cohort Study

Feldens¹,

Kramer²,

Cascaes³

et al. 2015

Pesqui. bras. odontopediatria clín. integr.

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Objective: To investigate the association between micronutrients intake at 12 months of age and the occurrence of severe early childhood caries (S-ECC) at four years of age among children in southern Brazil. Material and Methods: The baseline sample was made up of 500 mother-child pairs followed since the birth of the child in São Leopoldo, Brazil. After the first birthday, micronutrients intake (calcium, iron, sodium, zinc, vitamin A, vitamin C, vitamin B12 and folate) was recorded using the 24-hour recall method. At four years of age, a calibrated examiner evaluated the occurrence of S-ECC based on internationally accepted criteria. Poisson regression was used to investigate associations between exposures and the outcome. Results: The final sample comprised 314 children. The occurrence of S-ECC was higher among children who consumed less calcium (p=0.009), zinc (p=0.021) and vitamin C (p=0.036). However, after the multivariable adjustments, no micronutrient was associated with the occurrence of S-ECC. Conclusion: A lower intake of micronutrients at 12 months of age did not represent a risk factor for the occurrence of S-ECC at four years of age, suggesting that advice on feeding practices for dental caries prevention should focus mainly on dietary aspects (local effect) rather than nutritional aspects (systemic effect).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No Impact of Lower Intake of Micronutrients on Severe Early Childhood Caries: Findings from a Prospective Cohort Study

Feldens¹,

Kramer²,

Cascaes³

et al. 2015

Pesqui. bras. odontopediatria clín. integr.

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“…A amostragem por conveniência realizada neste estudo pode gerar potenciais vieses de seleção, pois não há como saber se todas as pessoas Tabela 2 Índices CPOD e ceod, desvio-padrão (DP) e livres de cárie, por faixa etária, na população rural ribeirinha, rio Machado e rio Além disso, aos 12 anos de idade, 33% da população estudada possui CPOD > 3,0; e 30% são livres de cárie, sugerindo uma concentração da doença cárie, fato observado em diversos estudos, nas mais diferentes populações 3,7,16,17,18 . Nesse sentido, Narvai et al 3 afirmam que, no Brasil, 20% dos escolares passaram a concentrar 60% da carga da doença.…”

Section: Discussionunclassified

Cárie dentária em população ribeirinha do Estado de Rondônia, Região Amazônica, Brasil, 2005/2006

et al. 2008

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This study aimed to analyze dental caries patterns among riverine people from Rondônia State, Brazil (Machado and Preto rivers) in 2005 and2006. A total of 469 subjects were examined, using the World Health Organization form, under natural light, using a wooden tongue depressor and CPI probe in cases of doubts about the presence of dental caries. The results were: [6][7][8][9][10] DMTF = 1.04, 12 years, 18 years,[35][36][37][38][39][40][41][42][43][44][65][66][67][68][69][70][71][72][73][74] DMTF = 21.56 [0][1][2][3][4][5][6][7][8][9][10]12, in and 4.34% caries-free. When each component was analyzed separately in the dmtf and DMTF indices, decay was most prevalent in the IntroduçãoAs condições de saúde bucal em nível individual e coletivo são avaliadas, principalmente, pela aná-lise da ocorrência de cárie dentária. O declínio da prevalência da cárie, em populações jovens, pode ser notado mundialmente, principalmente nas últimas três décadas, nas mais diferentes localidades 1,2,3 .Em populações social e economicamente desfavorecidas, a prevalência de doenças passí-veis de prevenção geralmente se apresenta mais elevada quando comparada com localidades mais desenvolvidas. A cárie dentária também segue esse padrão de distribuição, seja por falta de informação da população sobre os cuidados com a higiene bucal ou por falta de acesso ao tratamento odontológico 4,5,6,7,8,9 .Quanto à região do estudo, observa-se que o inquérito SB Brasil 2003 10 constatou os seguintes índices para a Região Norte: ceod 1,34 (até os 3 anos de idade); ceod 3,22 (aos 5 anos de idade); CPOD 3,13 (aos 12 anos de idade); CPOD 6,14 (15-19 anos de idade); CPOD 19,88 (35-44 anos de idade); CPOD 28,34 (65-74 anos de idade).E inserida nessa região, a população do Município de Porto Velho, Estado de Rondônia, local do presente estudo, caracteriza-se por possuir 371.791 habitantes, sendo cerca de 30% residente em área rural e rural-ribeirinha 11 .Dessa forma, o objetivo deste trabalho é apresentar os dados do levantamento de cárie dentá-ARTIGO ARTICLE

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“…According to MacKeown et al [2003], vitamin B 12 was significantly associated with caries incidence. In addition, Kwan et al [1998] reported a higher caries incidence in children with low levels of folic acid.…”

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confidence: 99%

A Polymorphism in the <b><i>MTRR</i></b> Gene Is Associated with Early Childhood Caries and Underweight

Antunes¹,

Machado²,

Couto³

et al. 2017

Caries Res

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Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B₁₂. The present study aimed to evaluate the association of polymorphisms in genes MTR (rs1805087) and MTRR (rs1801394) with susceptibility of early childhood caries (ECC) and with body mass index alterations. A cross-sectional study was performed in 488 children aged from 2 to 6 years from 25 public day care centers in Rio de Janeiro, Brazil. Demographic data and oral health habits were obtained through a questionnaire. Anthropometric measurements and caries experience data were collected by 2 examiners (κ = 0.80). Genotyping of the selected polymorphisms was carried out by TaqMan real-time PCR using genomic DNA extracted from buccal cells. Allele and genotype frequencies were compared between groups with and without disease. The t test, χ² test, odds ratio, Pearson correlation tests, and logistic regression analysis were used (p ≤ 0.05). The mean white spot lesion score was 1.18 (±2.57) in normal weight children and 2.50 (±3.87) in underweight children (p = 0.05). For MTRR polymorphisms, significant differences were observed for allele and genotype frequency distributions between caries-free and caries-affected children (p = 0.03 and 0.04 for allele and genotype frequencies, respectively) and in the genotype frequencies between normal weight and underweight children (p = 0.04). Our results suggest an association between underweight and ECC; in addition it is suggested that MTRR is a common genetic risk factor for ECC and underweight.

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Caries and micronutrient intake among urban South African children: a cohort study

Abstract: The association of micronutrient intake with caries was weak, isolated and not clinically relevant. Micronutrient intake was not an indicator of the presence or absence of caries among the children studied.

Cited by 18 publications

References 36 publications

No Impact of Lower Intake of Micronutrients on Severe Early Childhood Caries: Findings from a Prospective Cohort Study

No Impact of Lower Intake of Micronutrients on Severe Early Childhood Caries: Findings from a Prospective Cohort Study

Cárie dentária em população ribeirinha do Estado de Rondônia, Região Amazônica, Brasil, 2005/2006

A Polymorphism in the <b><i>MTRR</i></b> Gene Is Associated with Early Childhood Caries and Underweight

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