Carica papaya Leaf Extract Inhibits SARS-CoV-2 Main Proteases but not Human TMPRSS2: An In-vitro and In-silico Study

Hariono, Maywan; Hidayat, Irwan; Djunarko, Ipang; Julianus, Jeffry; Saqallah, Fadi G.; Khawory, Muhammad Hidhir; Salin, Nurul Hanim; Wahab, Habibah A.

doi:10.48550/arxiv.2212.00273

Cited by 1 publication

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“…Santana et al (2021) presented a list of different bioactive compounds against SARS-CoV-2 for many medicinal plant species, of which the active ingredient in Morus alba was considered to have great potential [6]. A study by Arm Adel et al (2022) showed that papaya extract had significant effects in the treatment of dengue virus with antiviral, immunomodulatory, and cytokine storm-reducing properties, so it would reduce inflammatory conditions caused by COVID-19 [7], [8].…”

Section: Introductionmentioning

confidence: 99%

Research on Formulation of Hard Capsules Containing Extracts of Houttuynia Cordata Thumb (Saururaceae), Morus Alba L. (Moraceae), and Carica Papaya L. (Caricaceae)

Huynh,

Nguyen,

et al. 2023

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Background: previous studies have demonstrated that Houttuynia cordata Thumb (Saururaceae), Morus alba L. (Moraceae), and Carica papaya L. (Caricaceae) are effective against various viruses, especially the SARS-CoV-2 virus. In Vietnam, even though the three of these plant species are grown quite popularly and are pretty commonly consumed by residents regularly, there have not been any applications to the dosage forms to promote their full potential effects and make these dosage forms easy to use and preserve. Furthermore, no research has been conducted on a capsule form that combines all three of these medicinal herbs. Objectives: the research focuses on the composition of a hard capsule formula containing the extracts of Houttuynia cordata, Morus alba, and Carica papaya as well as the development of testing standards for prepared hard capsules. Materials and methods: the ratio of adsorbents and fillers in the formula was investigated so that the granules had low moisture, a suitable flow rate, and the appropriate apparent density for packaging; standards for testing capsules were developed according to current regulations. Results: the selected adsorbent was light MgCO3, with a ratio of plant extract: filler: adsorbent of 10: 5: 0.5 and a ratio of Avicel: Starch 1500 of 1: 3. Conclusions: a hard capsule containing medicinal plant extract was formulated with a moisture content of < 5% and well-flowing granules that had the suitable apparent density for packing the capsule size of 0. Capsules met standards in terms of appearance, weight uniformity, disintegration, heavy metal and microorganisms, with a quercetin content of 74.45 ± 0.23 mg. The result of the study is considered one of the most essential bases for further research on determining the effectiveness of medicines derived from medicinal plants and applied to support the treatment of COVID-19, which is still happening in a quite complicated way at the moment.

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Section: Introductionmentioning

confidence: 99%