Carica papaya ameliorates allergic asthma via down regulation of IL-4, IL-5, eotaxin, TNF-α, NF-ĸB, and iNOS levels

Inam, Asma; Shahzad, Muhammad; Shabbir, Arham; Shahid, Hira; Shahid, Khadija; Javeed, Aqeel

doi:10.1016/j.phymed.2017.04.009

Cited by 59 publications

(32 citation statements)

References 43 publications

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“…ere is also convincing evidence that increased immunoglobulin E (IgE) levels and goblet-cell hyperplasia are observed in asthma [3]. e prevalence of asthma is increasing worldwide, and it has become a significant cause of health challenge especially in developed countries [4].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Pelargonium sidoides and Coptis Rhizoma 2 : 1 Mixed Formula (PS + CR) on Ovalbumin‐Induced Asthma in Mice

Min

Park

Choi

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Pelargonium sidoides (PS) is traditionally used to treat respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders in South Africa. Coptis Rhizoma (CR) is used to treat gastroenteric disorders, cardiovascular diseases, and cancer in East Asia. In the present study, we intended to observe the possible beneficial antiasthma effects of PS and CR on the ovalbumin- (OVA-) induced asthma C57BL/6J mice. Asthma in mice was induced by OVA sensitization and subsequent boosting. PS + CR (300 and 1,000 mg/kg; PO) or dexamethasone (IP) was administered once a day for 16 days. The changes in the body weight and gains, lung weights and gross inspections, total and differential cell counts of leukocytes in bronchoalveolar lavage fluid (BALF), serum OVA-specific immunoglobulin E (OVA-sIgE) levels, interleukin-4 (IL-4) and IL-5 levels in BALF and lung tissue homogenate, and IL-4 and IL-5 mRNA levels in lung tissue homogenates were analyzed with lung histopathology: mean alveolar surface area (ASA), alveolar septal thickness, numbers of inflammatory cells, mast cells, and eosinophils infiltrated in the alveolar regions, respectively. Significant increases in lung weights, total and differential cell counts of leukocytes in BALF, serum OVA-sIgE levels, and IL-4 and IL-5 levels in BALF and lung tissue homogenate were observed in OVA control as compared to those of intact control. In addition, OVA control showed a significant decrease in mean ASA and increases in alveolar septal thickness, numbers of inflammatory cells, mast cells, and eosinophils infiltrated in alveolar regions. However, these allergic and inflammatory asthmatic changes were significantly inhibited by PS + CR in a dose-dependent manner. In this study, PS + CR showed dose-dependent beneficial effects on OVA-induced asthma in mice through anti-inflammatory and antiallergic activities. Therefore, it is expected that PS + CR have enough potential as a new therapeutic agent or as an ingredient of a medicinal agent for various allergic and inflammatory respiratory diseases including asthma.

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Section: Introductionmentioning

confidence: 99%

“…Eosinophils differentiate within tissues undergoing an allergic response, including asthma [11]. us, regulating the IL-4 or IL-5 is a useful therapeutic approach in allergic asthma [4,12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Pelargonium sidoides and Coptis Rhizoma 2 : 1 Mixed Formula (PS + CR) on Ovalbumin‐Induced Asthma in Mice

Min

Park

Choi

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…As a result, traditional therapies based on plants are currently being reassessed. A number of studies have confirmed the effectiveness of herbs, natural products, and herbal formulae for asthma therapy, such as Bupleurum [18], Carica papaya [19], Zerumbone [20], and Bu-Shen-Yi-Qi formulae [21]. M. dauricum DC.…”

Section: Discussionmentioning

confidence: 99%

“…These Th2 cytokines orchestrate the eosinophil recruitment, IgE production, inflammatory cell infiltration, and mucus hyperproduction [33]. IL-4 can drive the polarization of naïve CD4 + T lymphocytes, promote the differentiation of Th cells from Th0 to the Th2 pattern, and induce Th2 lymphocytes secreting cytokines [19]. Meanwhile, IL-4 can promote the class switching of B lymphocyte cells to plasma cells, then produce IgE [34].…”

Section: Discussionmentioning

confidence: 99%

“…IL-5 is considered to be the key target for the initiation and maintenance of eosinophilic airway inflammation in allergic asthma. IL-5 can induce eosinophil chemotaxis, enhance B cell differentiation and growth, and promote eosinophil adhesion molecule expression [19]. Anti-IL-5 therapy can significantly downregulate the eosinophils level in sputum and blood of asthmatic patients [23].…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Total Alkaloids from Menispermum dauricum against Airway Inflammation in Asthmatic Mice

Yin

You

et al. 2020

Planta Med

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Abstract Menispermum dauricum is widely used to treat respiratory inflammation, including laryngopharyngitis, tonsillitis, tracheitis, and bronchitis. Total alkaloids isolated from M. dauricum have shown a variety of beneficial bioactivities. However, available data on the effects of M. dauricum total alkaloids against allergic asthma has not been reported. In present study, the protective effect of M. dauricum total alkaloids was evaluated by using an ovalbumin-induced in vivo model of asthma. The asthma model was prepared by sensitizing and challenging mice with ovalbumin, and M. dauricum total alkaloids (100, 200, and 400 mg/kg) were administrated to asthmatic mice by gavage. Histopathological analysis of pulmonary changes was detected by hematoxylin and eosin, and periodic acid-schiff staining. Inflammatory cell counts were determined in bronchoalveolar lavage fluid. Total immunoglobulin E and ovalbumin-specific immunoglobulin E levels in serum, and T-helper 2 cytokines and chemokine levels in bronchoalveolar lavage fluid were detected by an ELISA. Histological results demonstrated that M. dauricum total alkaloids significantly attenuated pulmonary inflammation in asthmatic mice. M. dauricum total alkaloid treatment exhibited marked effects on asthmatic mice in reducing inflammatory cell counts, decreasing interleukin-4, interleukin-5, and interleukin-13 concentrations, and downregulating TNF-α and eotaxin levels in bronchoalveolar lavage fluid. In addition, M. dauricum total alkaloids could also inhibit the elevated serum levels of total immunoglobulin E and ovalbumin-specific immunoglobulin E. These findings confirmed that M. dauricum total alkaloids could suppress airway inflammation in ovalbumin-induced asthma through regulating the T-helper 2 response and chemokine level. M. dauricum total alkaloids may be a potential ethnopharmacological agent for asthmatic patients.

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Papaya Waste as a Nutraceuticals Product

Das,

Prasad

2024

Nutraceuticals From Fruit and Vegetable Waste

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Carica papaya ameliorates allergic asthma via down regulation of IL-4, IL-5, eotaxin, TNF-α, NF-ĸB, and iNOS levels

Cited by 59 publications

References 43 publications

Effects of Pelargonium sidoides and Coptis Rhizoma 2 : 1 Mixed Formula (PS + CR) on Ovalbumin‐Induced Asthma in Mice

Effects of Pelargonium sidoides and Coptis Rhizoma 2 : 1 Mixed Formula (PS + CR) on Ovalbumin‐Induced Asthma in Mice

Protective Effects of Total Alkaloids from Menispermum dauricum against Airway Inflammation in Asthmatic Mice

Papaya Waste as a Nutraceuticals Product

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